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Vol. 21. Issue 2.
Pages 76-81 (July - December 2020)
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Vol. 21. Issue 2.
Pages 76-81 (July - December 2020)
Original article
Influence of HLA-G polymorphism in antibody response to hepatitis B vaccination during the first year of life
Influencia del polimorfismo HLA-G en la respuesta de anticuerpos a la vacuna frente a la hepatitis B durante el primer año de vida
A.A. El Shahawaya,
Corresponding author
aliaabdelmonem@yahoo.com

Corresponding author.
, A.A. Ahmedb, M.A. Arafac, M.M. Maleka
a Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
b Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
c Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
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Figures (1)
Tables (3)
Table 1. Baseline characteristics of the participants.
Table 2. Association of HLA-G 14bp polymorphism with response to the HB vaccine.
Table 3. Distribution of anti-HBs titer (IU/mL) according to genotypes in responder and non-responder groups.
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Abstract
Objective

This research intended to evaluate the antibody response to vaccination against hepatitis B during the first year of life. We also aimed to assess the association between the antibody response to hepatitis B vaccination and the polymorphism in HLA-G 14bp.

Material and methods

In this comparative cross-sectional study, 93 infants that received the hepatitis B vaccine at 2, 4, and 6 months old according to the World Health Organization immunization schedules, were evaluated for their antibodies to HBsAg (anti-HBs) following vaccination. Their genomic DNA was extracted and examined for the polymorphism in HLA-G 14bp by PCR.

Results

Among 93 vaccinated infants, 11 infants (11.8%) were non-responders to vaccination against hepatitis B (anti-HBs<10IU/mL). The mean antibody titers for responders and non-responders were 77.65±27.14IU/mL and 4.45±2.38IU/mL, respectively. The 14-bp insertion allele was associated with an increased risk of failure o respond to hepatitis B vaccination (OR 3.72, 95% CI 1.32–10.6).

Conclusion

This study reported, for the first time, that ins/ins genotype may be a risk factor for non-responsiveness to hepatitis B vaccination.

Keywords:
Hepatitis B Vaccination
Humoral immunity
HLA-G 14bp in/del
Infants
Resumen
Objetivo

El objetivo de este estudio fue evaluar la respuesta de anticuerpos a la vacuna frente a la hepatitis B durante el primer año de vida. También tratamos de evaluar la asociación entre la respuesta de anticuerpos a la vacuna frente a la hepatitis B y el polimorfismo en HLA-G 14bp.

Material y métodos

En este estudio transversal comparativo se evaluó el HBsAg (anti-HBS) de 93 niños que recibieron la vacuna contra la hepatitis B a los 2, 4 y 6 meses de edad, conforme a los programas de la Organización Mundial de la Salud, fueron evaluados por sus anticuerpos frente a HBsAg (anti-HBs) después de la vacunación. Se extrajo su ADN genómico. examinándose el polimorfismo en HLA-G 14bp mediante la prueba PCR.

Resultados

Entre los 93 niños vacunados, 11 niños (11,8%) no respondieron a la vacuna frente a la hepatitis B (anti-HBs<10UI/mL). Los títulos de anticuerpos medios para respondedores y no respondedores fueron de 77,65±27,14 y 4,45±2,38UI/mL, respectivamente. El alelo 14bp inserción se asoció a un incremento del riesgo de fallo de respuesta a la vacuna frente a la hepatitis B (OR: 3,72; IC 95%: 1,32-10,6).

Conclusión

Este estudio reportó, por vez primera, que el genotipo ins/ins puede constituir un factor de riesgo para la no respuesta a la vacuna frente a la hepatitis B.

Palabras clave:
Vacunación contra la hepatitis B
Inmunidad humoral
HLA-G 14bp in / del
Lactantes

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