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Inicio Vacunas (English Edition) Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-CO...
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Vol. 23. Issue S1.
Pages S14-S21 (August 2022)
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Vol. 23. Issue S1.
Pages S14-S21 (August 2022)
Original article
Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers
Evaluación de la respuesta de anticuerpos igg específicos contra SARS-CoV-2 en personal de salud con esquema completo de vacuna Sputnik V (GAM-COVID-VAC)
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Ezequiel Cordovaa,
Corresponding author
dr_ecordova@hotmail.com

Corresponding author at: Pi y Margall 750 (1155), Buenos Aires, Argentina.
, M. Ines Lespadaa, Diego Cecchinia, Fabiola Nietob, Susana Palonskib, Mariana Badranc, Silvina Bernasconic, Brenda Bacelara, Laura Morgantia, Franco Garibaldia, Veronica Bermejoa, Viviana Aguirrec, Marcela Badiab, Claudia G. Rodrigueza
a Unidad de Infectología. Hospital Cosme Argerich, Pi y Margall 750 (1155), Buenos Aires, Argentina.
b Laboratorio Central. Hospital Cosme Argerich, Pi y Margall 750 (1155), Buenos Aires, Argentina.
c Unidad de Protección y Promoción. Hospital Cosme Argerich, Pi y Margall 750 (1155), Buenos Aires, Argentina.
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Tables (3)
Table 1. Characteristics of 630 healthcare workers vaccinated with the full Sputnik V schedule
Table 2. Multivariate analysis of factors associated with the detection of anti-SARS-CoV-2 antibodies in 630 healthcare workers vaccinated with Sputnik Va
Table 3. Multivariate analysis of factors associated with elevated anti-SARS-CoV-2 antibody response (S/Co > 8) in 630 health-care workers vaccinated with Sputnik V.a
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Vol. 23. Issue S1
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Abstract
Background

Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate the antibody response against SARS-CoV-2 in HCWs with complete Sputnik V vaccine scheme and factors associated with an increased antibody response.

Material and methods

Prospective study to evaluate the anti-SARS-CoV-2 humoral response in HCWs vaccinated with two doses of the Sputnik V vaccine (April-July 2021). The assessment of anti-Spike IgG antibodies in plasma was performed using the COVIDAR IgG enzyme-linked immunosorbent assay. A logistic regression was performed to identify independent factors associated with a positive IgG serology test and an elevated antibody response.

Results

A total of 630 HCWs were enrolled. Median age (IQR): 47 years (35-56). Female sex: 462 (73.33%). Previous COVID-19: 158 (25%). The median interval time between vaccine doses was 3 (3-4) weeks. Positive serology was observed in 607 (96.35%) HCWs. In the multivariate analysis, a history of systemic reactogenicity was identified as an independent variable associated with a positive serology; and history of systemic reactogenicity, COVID-19, interval between doses ≥4 weeks and time to serology <14 weeks were associated with an elevated antibody response.

Conclusions

This study provides data on the humoral response to the Sputnik V vaccine in a real-life setting. These initial data can contribute to the development of future immunization strategies in HCWs.

Keywords:
SARS-CoV-2
COVID-19
vaccines
pandemic
Sputnik V vaccine
healthcare workers
Resumen

Introducción

La vacunación para COVID-19 en el personal de salud (PDS) es fundamental para proteger a una de las poblaciones más expuestas a esta enfermedad. Sin embargo, los datos de la tasa de respuesta humoral a la vacuna y los factores asociados a la misma en esta población son limitados. Nuestros objetivos fueron evaluar la respuesta de anticuerpos contra SARS-CoV-2 en el PDS con esquema completo de vacuna Sputnik V y los factores asociados con una mayor respuesta de anticuerpos.

Materiales y métodos

Estudio prospectivo de evaluación de la respuesta humoral anti SARS-CoV-2 en PDS con esquema completo de vacuna Sputnik V mediante el enzimoinmunoensayo COVIDAR IgG (abril–julio 202). Se realizó una regresión logística para identificar factores independientes asociados con una prueba de serología IgG positiva y con respuesta elevada de anticuerpos.

Resultados

Se enrolaron 630 PDS. Mediana (RIC) de edad: 47 años (35-56). Sexo femenino: 462 (73.33%). COVID previo: 158 (25%). Mediana de tiempo entre las dosis de vacuna fue 3 (3-4) semanas. Presentaron serología reactiva 607 (96.35%). En el análisis multivariado se identificó como variable independiente asociada a serología positiva al antecedente de reactogenicidad sistémica a la vacuna; y con respuesta elevada de anticuerpos al antecedente de reactogenicidad sistémica a la vacuna, COVID-19 previo, intervalo entre dosis ≥4 semanas y tiempo a serología <14 semanas.

Conclusiones

Este estudio proporciona datos de la respuesta humoral a la vacuna Sputnik V en un escenario de vida real. Estos datos iniciales pueden contribuir al desarrollo de futuras estrategias de inmunización en el personal de salud.

Palabras clave:
SARS-CoV-2
COVID-19
Vacunas
Pandemia
Vacuna Sputnik V
Personal de salud

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