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Vol. 69. Issue 1.
Pages 34-42 (January 2022)
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Vol. 69. Issue 1.
Pages 34-42 (January 2022)
Original article
SARS-CoV-2 infection. Descriptive analysis of a selected case series
Infección por SARS-CoV-2. Análisis descriptivo de una serie de casos seleccionada
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C.L. Errando
Corresponding author
errando013@gmail.com

Corresponding author.
, C.S. Romero-García, M.J. Hernández-Cádiz, M.Á. Pallardó-López, J. Puig
Consorcio Hospital General Universitario de Valencia, Valencia, Spain
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Tables (4)
Table 1. Demographic characteristics, symptoms, results of RT-PCR for SARS-CoV-2, and outcome.
Table 2. Laboratory data from the 4 patients admitted to the ICU. Patients 1 and 2 survived, patients 5 and 6 died in the ICU.
Table 3. Details of ICU stay.
Table 4. Description of ECG and radiological findings in patients admitted to the ICU.
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Additional material (1)
Abstract
Objectives

COVID-19 was declared pandemic by March 2020. Clinical, analytical, and radiological findings have been reported. Detailed different evolution of patients of the same local outbreak has been scarcely reported. We report 6 selected cases of such an evolution.

Clinical cases

The clinical, radiological, analytical evolution of 6 patients is reported. Patients were selected as it were epidemiological close contacts, and showed particular different clinical evolution.

Results

The clinical course at the start of infection (first week) was similar among patients. In relationship with clinical evolution, middle to severe course were related with inflammation markers levels evolution (D-dimer, IL-6, ferritin, lymphocytes count, etc.). Specially lung alterations were observed, but neurological/neuropsychiatric findings are still common. In evolution, 2 patients showed middle symptoms, but the 2 most severely affected died.

Conclusions

It remains to be elucidated the different evolutive pathways and outcomes of COVD-19. In our 6 patients of the same local outbreak, clinical, laboratory and radiological features were different. We discuss some aspects of the pathophysiology of the disease, other than the widely described of the respiratory system.

Keywords:
Coronavirus
COVID-19
Outbreak
Complications
ICU
Resumen
Objetivos

La COVID-19 fue declarada pandemia en marzo del 2020. Han sido comunicados los hallazgos clínicos, analíticos y radiológicos. Sin embargo, la diversa evolución de pacientes del mismo brote local lo ha sido escasamente. Comunicamos en este trabajo 6 casos seleccionados de tal evolución.

Casos clínicos

Se expone la evolución clínica, radiológica y analítica de 6 pacientes. Estos fueron seleccionados ya que fueron epidemiológicamente contactos estrechos y mostraron una evolución clínica particularmente diferente.

Resultados

El curso clínico al inicio de la infección (primera semana) fue similar entre los pacientes. En relación con la evolución clínica, un curso moderado a severo se relacionó evolutivamente con marcadores elevados de inflamación (dímero D, IL-6, ferritina, linfopenia, etc.). Fueron observadas alteraciones pulmonares típicas, pero fueron comunes también hallazgos neurológicos y neuropsiquiátricos. En la evolución 2 pacientes mostraron síntomas moderados, pero los 2 más gravemente afectados murieron.

Conclusiones

Está por elucidar las diferentes vías evolutivas y resultados finales de los pacientes con COVID-19. En nuestros 6 pacientes del mismo brote local, las características clínicas, de laboratorio y radiológicas fueron diferentes. Discutimos aspectos de la fisiopatología de la enfermedad distintos de los ampliamente descritos del sistema respiratorio.

Palabras clave:
Coronavirus
COVID-19
Brote epidémico
Complicaciones
UCI

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