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Vol. 67. Issue 3.
Pages 163-166 (March 2020)
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Vol. 67. Issue 3.
Pages 163-166 (March 2020)
Case report
Propofol infusion syndrome; are high doses always required?
Síndrome por infusión de propofol; ¿realmente se requieren altas dosis?
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13
A. Subirà Gonzáleza,
Corresponding author
asubiragonzalez@gmail.com

Corresponding author.
, M. Fernández Moralesa, E. Sánchez Royoa, Y. Boliart de San Félixa, C. Vila Lolob
a Departamento de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital Universitario Dexeus, Barcelona, Spain
b Departamento de Digestivo, Hospital Universitario Dexeus, Barcelona, Spain
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Table 1. Differential diagnosis of hepatotoxicity in this case.
Abstract

Propofol infusion syndrome is a rare condition that mainly affects critically ill patients who receive high doses of this hypnotic for a long time. We describe the case of a patient who presented twice hepatotoxicity in the immediate postoperative period of two surgeries in which she had received conventional doses of propofol during a short period of time. After studying the patient and monitoring her evolution, we arrived at a differential diagnosis of propofol infusion syndrome due to increased susceptibility. This syndrome should be considered in patients presenting hepatotoxicity in the immediate postoperative period, even when low doses of propofol have been administered.

Keywords:
Hepatotoxicity
Propofol
Propofol infusion syndrome
Resumen

El síndrome por infusión de propofol es una entidad poco frecuente que afecta principalmente a pacientes críticos que reciben dosis elevadas de este hipnótico durante un tiempo prolongado. Describimos el caso de una paciente que presentó en dos ocasiones hepatotoxicidad en el periodo postoperatorio inmediato de dos cirugías en las que había recibido dosis convencionales de propofol en un periodo corto de tiempo. Después de su estudio, evolución y diagnóstico diferencial, se orienta como posible síndrome por infusión de propofol a causa de una susceptibilidad aumentada. Ante la aparición de una hepatotoxicidad en el postoperatorio inmediato debería tenerse presente esta entidad como posible causa aunque las dosis administradas sean bajas.

Palabras clave:
Hepatotoxicidad
Propofol
Síndrome infusión propofol

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