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Revista Española de Anestesiología y Reanimación (English Edition)
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Vol. 68. Issue 5.
Pages 293-296 (May 2021)
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Vol. 68. Issue 5.
Pages 293-296 (May 2021)
Case report
Combination gel of 2% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain – a case report of pain control success
Gel tópico de amitriptilina al 2% y ketamina al 0,5% para el tratamiento de la eritromelalgia: reporte de un caso con respuesta positiva al dolor
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F. Portugala,b,
Corresponding author
Francisco.portugal@gmail.com

Corresponding author.
, A. Araújoa,b, C. Silvaa,b, M. Camposa,b, A. Valentima,b
a Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
b Chronic Pain Unit, Department of Anaesthesiology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
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Abstract

Erythromelalgia (EM) is a rare autosomal dominant neuropathy characterized by the combination of severe burning pain and erythematous warm extremities. Chronic pain control is most often unsuccessful and a completely effective therapy is yet to be identified. Recent studies have reported significant improvements in pain management using a combination of amitriptyline and ketamine in a topical formulation. We describe a 1-year follow-up pain control success case of a male patient with EM, proposed for topical use of a 2% Amitriptyline and 0.5% Ketamine gel.

Keywords:
Erythromelalgia
Chronic pain
Ketamine
Amitriptyline
Topical
Resumen

La eritromelalgia (EM) es una rara neuropatía autosómica dominante caracterizada por la combinación de ardor intenso, extremidades eritematosas y cálidas. Con frecuencia el control del dolor crónico no tiene éxito, no habiéndose identificado aún una terapia efectiva. Los estudios recientes han identificado mejoras significativas en el manejo de dolor, utilizando una combinación de amitriptilina y ketamina en formulación tópica. Describimos un caso de respuesta positiva al dolor, con seguimiento de 1 año, de un paciente con EM usando un gel tópico de combinación de amitriptilina al 2% y ketamina al 0,5%.

Palabras clave:
Eritromelalgia
Dolor crónico
Ketamina
Amitriptilina
Tópico

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