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Radiología (English Edition) Usefulness of intestinal ultrasound in inflammatory bowel disease
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Vol. 63. Issue 1.
Pages 1-102 (January - February 2021)
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Vol. 63. Issue 1.
Pages 1-102 (January - February 2021)
Serie: Ultrasound of the gastrointestinal tract

Usefulness of intestinal ultrasound in inflammatory bowel disease

Utilidad de la ecografía intestinal en la enfermedad inflamatoria intestinal
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13456
T. Ripollésa,
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ripolles_tom@gva.es

Corresponding author.
, F. Muñozb, M.J. Martínez-Péreza, E. de Miguelc, J. Poza Cordónd, B. de la Heras Páez de la Cadenae
a Servicio de Radiología, Hospital Dr. Peset, Valencia, Spain
b Servicio de Digestivo, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
c Servicio de Radiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
d Servicio de Digestivo, Hospital Universitario La Paz, Madrid, Spain
e Servicio de Digestivo, Hospital Universitario 12 de Octubre, Madrid, Spain
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This article is part of special issue:
Ultrasound of the gastrointestinal tract

Edited by: Dr. Tomás Ripollés González - Servicio de Radiodiagnóstico, Hospital Universitari Doctor Peset, València, España

Last update: April 2021

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Abstract

Imaging techniques play a fundamental role in the initial diagnosis and follow-up of inflammatory bowel disease. Intestinal ultrasound has high sensitivity and specificity in patients with suspected Crohn’s disease and in the detection of inflammatory activity. This technique enables the early diagnosis of intra-abdominal complications such as stenosis, fistulas, and abscesses. It has also proven useful in monitoring the response to treatment and in detecting postsurgical recurrence. Technical improvements in ultrasound scanners, technological advances such as ultrasound contrast agents and elastography, and above all increased experience have increased the role of ultrasound in the evaluation of the gastrointestinal tract. The features that make ultrasound especially attractive include its wide availability, its noninvasiveness and lack of ionising radiation, its low cost, and its good reproducibility, which is important because it is easy to repeat the study and the study is well tolerated during follow-up. This review summarizes the role of intestinal ultrasound in the detection and follow-up of inflammatory bowel disease.

Keywords:
Crohn’s disease
Ulcerative colitis
Monitoring
Transmural healing
Postsurgical recurrence
Ultrasound
Resumen

Las técnicas de imagen desempeñan un papel fundamental en el diagnóstico inicial y seguimiento de la enfermedad inflamatoria intestinal. La ecografía intestinal tiene alta sensibilidad y especificidad en la sospecha de la enfermedad de Crohn, en la detección de actividad inflamatoria y permite el diagnóstico temprano de complicaciones intraabdominales, como estenosis, fístulas y abscesos; además, ha demostrado su utilidad en la monitorización del tratamiento y en la recurrencia posquirúrgica. El desarrollo técnico de los equipos de ecografía, la incorporación de avances tecnológicos como el contraste ecográfico o la elastografía y, sobre todo, una mayor experiencia, han impulsado su papel en la evaluación de la patología del tubo digestivo. La ecografía es particularmente atractiva gracias a su amplia disponibilidad, su inocuidad, bajo coste y buena reproducibilidad, ya que puede repetirse de forma fácil y bien tolerada por el paciente durante el seguimiento. Esta revisión resume el papel de la ecografía intestinal en la detección y seguimiento de pacientes con enfermedad inflamatoria intestinal.

Palabras clave:
Enfermedad de Crohn
Colitis ulcerosa
Monitorización
Curación transmural
Recurrencia posquirúrgica
Ecografía

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References
[1]
F. Gomollon, A. Dignass, V. Annese, H. Tilg, G. Van Assche, J.O. Lindsay, et al.
3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management.
J Crohns Colitis., 11 (2017), pp. 3-25
[2]
D. Strobel, R.S. Goertz, T. Bernatik.
Diagnostics in inflammatory bowel disease: ultrasound.
World J Gastroenterol., 17 (2011), pp. 3192-3197
[3]
C. Maaser, A. Sturm, S.R. Vavricka, T. Kucharzik, G. Fiorino, V. Annese, et al.
ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications.
J Crohns Colitis., 13 (2019), pp. 144-164
[4]
J. Panes, R. Bouzas, M. Chaparro, V. Garcia-Sanchez, J.P. Gisbert, B. Martinez de Guerenu, et al.
Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn’s disease.
Aliment Pharmacol Ther., 34 (2011), pp. 125-145
[5]
K. Horsthuis, S. Bipat, R.J. Bennink, J. Stoker.
Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: meta-analysis of prospective studies.
Radiology., 247 (2008), pp. 64-79
[6]
T. Ripollés González, M.J. Martínez Pérez.
Técnicas seccionales de imagen en la enfermedad de Crohn: ecografía, tomografía computarizada y resonancia magnética.
Radiologia., 49 (2007), pp. 97-108
[7]
A.S. Day, O. Ledder, S.T. Leach, D.A. Lemberg.
Crohn’s and colitis in children and adolescents.
World J Gastroenterol., 18 (2012), pp. 5862-5869
[8]
M.J. Martínez Pérez, E. Blanc, J. Merino.
Técnicas de examen. Semiología ecográfica.
Radiología, (2020),
[9]
G. Bouguen, B.G. Levesque, S. Pola, E. Evans, W.J. Sandborn.
Endoscopic assessment and treating to target increase the likelihood of mucosal healing in patients with Crohn’s disease.
Clin Gastroenterol Hepatol., 12 (2014), pp. 978-985
[10]
R.V. Bryant, A. Friedman, E.K. Wright, K. Taylor, J. Begun, G. Maconi, et al.
Gastrointestinal ultrasound in inflammatory bowel disease: an underused resource with potential paradigm-changing application.
[11]
F. Castiglione, P.P. Mainenti, G.D. De Palma, A. Testa, L. Bucci, G. Pesce, et al.
Noninvasive diagnosis of small bowel Crohn’s disease: direct comparison of bowel sonography and magnetic resonance enterography.
Inflamm Bowel Dis., 19 (2013), pp. 991-998
[12]
D. Muradali, D.R. Goldberg.
US of gastrointestinal tract disease.
Radiographics., 35 (2015), pp. 50-68
[13]
K. Nylund, G. Maconi, A. Hollerweger, T. Ripolles, N. Pallotta, A. Higginson, et al.
EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound.
Ultraschall Med., 38 (2017), pp. e1-e15
[14]
M. Fraquelli, A. Sarno, C. Girelli, C. Laudi, E. Buscarini, C. Villa, et al.
Reproducibility of bowel ultrasonography in the evaluation of Crohn’s disease.
Dig Liver Dis., 40 (2008), pp. 860-866
[15]
M. Fraquelli, A. Colli, G. Casazza, S. Paggi, A. Colucci, S. Massironi, et al.
Role of US in detection of Crohn disease: meta-analysis.
Radiology., 236 (2005), pp. 95-101
[16]
X. Ma, Y. Li, H. Jia, J. Zhang, G. Wang, X. Liu, et al.
Contrast-enhanced ultrasound in the diagnosis of patients suspected of having active Crohn’s disease: meta-analysis.
Ultrasound Med Biol., 41 (2015), pp. 659-668
[17]
Z. Serafin, M. Bialecki, A. Bialecka, L.M. Sconfienza, M. Klopocka.
Contrast-enhanced Ultrasound for Detection of Crohn’s Disease Activity: Systematic Review and Meta-analysis.
J Crohns Colitis., 10 (2016), pp. 354-362
[18]
C. Zhu, X. Ma, L. Xue, J. Xu, Q. Li, Y. Wang, et al.
Small intestine contrast ultrasonography for the detection and assessment of Crohn disease: A meta-analysis.
Medicine (Baltimore)., 95 (2016), pp. e4235
[19]
M. Allocca, G. Fiorino, C. Bonifacio, F. Furfaro, D. Gilardi, M. Argollo, et al.
Comparative Accuracy of Bowel Ultrasound Versus Magnetic Resonance Enterography in Combination With Colonoscopy in Assessing Crohn’s Disease and Guiding Clinical Decision-making.
J Crohns Colitis., 12 (2018), pp. 1280-1287
[20]
J.R. Dillman, E.A. Smith, R. Sanchez, M.A. DiPietro, S.F. Dehkordy, J. Adler, et al.
Prospective cohort study of ultrasound-ultrasound and ultrasound-MR enterography agreement in the evaluation of pediatric small bowel Crohn disease.
Pediatr Radiol., 46 (2016), pp. 490-497
[21]
S.A. Taylor, S. Mallett, G. Bhatnagar, R. Baldwin-Cleland, S. Bloom, A. Gupta, et al.
Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial.
Lancet Gastroenterol Hepatol., 3 (2018), pp. 548-558
[22]
G. Maconi, E. Bolzoni, A. Giussani, A.B. Friedman, P. Duca.
Accuracy and cost of diagnostic strategies for patients with suspected Crohn’s disease.
J Crohns Colitis., 8 (2014), pp. 1684-1692
[23]
G. Maconi, K. Nylund, T. Ripolles, E. Calabrese, K. Dirks, C.F. Dietrich, et al.
EFSUMB Recommendations and Clinical Guidelines for Intestinal Ultrasound (GIUS) in Inflammatory Bowel Diseases.
Ultraschall Med., 39 (2018), pp. 304-317
[24]
E. Calabrese, C. Maaser, F. Zorzi, K. Kannengiesser, S.B. Hanauer, D.H. Bruining, et al.
Bowel Ultrasonography in the Management of Crohn’s Disease. A Review with Recommendations of an International Panel of Experts.
Inflamm Bowel Dis., 22 (2016), pp. 1168-1183
[25]
T. Ripolles, M.J. Martinez, J.M. Paredes, E. Blanc, L. Flors, F. Delgado.
Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy.
Radiology., 253 (2009), pp. 241-248
[26]
K. Kunihiro, J. Hata, K. Haruma, N. Manabe, S. Tanaka, K. Chayama.
Sonographic detection of longitudinal ulcers in Crohn disease.
Scand J Gastroenterol., 39 (2004), pp. 322-326
[27]
C. Rigazio, E. Ercole, C. Laudi, M. Daperno, A. Lavagna, L. Crocella, et al.
Abdominal bowel ultrasound can predict the risk of surgery in Crohn’s disease: proposal of an ultrasonographic score.
Scand J Gastroenterol., 44 (2009), pp. 585-593
[28]
B.H. Drews, T.F. Barth, M.M. Hanle, A.S. Akinli, R.A. Mason, R. Muche, et al.
Comparison of sonographically measured bowel wall vascularity, histology, and disease activity in Crohn’s disease.
Eur Radiol., 19 (2009), pp. 1379-1386
[29]
M. Epifanio, M. Baldisserotto, J.V. Spolidoro, A. Gaiger.
Grey-scale and colour Doppler sonography in the evaluation of children with suspected bowel inflammation: correlation with colonoscopy and histological findings.
Clin Radiol., 63 (2008), pp. 968-978
[30]
T. Sasaki, R. Kunisaki, H. Kinoshita, H. Kimura, T. Kodera, A. Nozawa, et al.
Doppler ultrasound findings correlate with tissue vascularity and inflammation in surgical pathology specimens from patients with small intestinal Crohn’s disease.
BMC Res Notes., 7 (2014), pp. 363
[31]
T. Ripolles, M.J. Martinez-Perez, J.M. Paredes, J. Vizuete, G. Martin.
The Role of Intravenous Contrast Agent in the Sonographic Assessment of Crohn’s Disease Activity: Is Contrast Agent Injection Necessary?.
J Crohns Colitis., 13 (2019), pp. 585-592
[32]
J.M. Paredes, T. Ripolles, X. Cortes, M.J. Martinez, M. Barrachina, F. Gomez, et al.
Abdominal sonographic changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn’s Disease.
Dig Dis Sci., 55 (2010), pp. 404-410
[33]
T. Ripolles, M.J. Martinez, M.M. Barrachina.
Crohn’s disease and color Doppler sonography: response to treatment and its relationship with long-term prognosis.
J Clin Ultrasound., 36 (2008), pp. 267-272
[34]
T. Ripolles, J.M. Paredes, M.J. Martinez-Perez, J. Rimola, A. Jauregui-Amezaga, R. Bouzas, et al.
Ultrasonographic Changes at 12 Weeks of Anti-TNF Drugs Predict 1-year Sonographic Response and Clinical Outcome in Crohn’s Disease: A Multicenter Study.
Inflamm Bowel Dis., 22 (2016), pp. 2465-2473
[35]
J. Spalinger, H. Patriquin, M.C. Miron, G. Marx, D. Herzog, J. Dubois, et al.
Doppler US in patients with crohn disease: vessel density in the diseased bowel reflects disease activity.
[36]
A. De Franco, A. Di Veronica, A. Armuzzi, I. Roberto, M. Marzo, B. De Pascalis, et al.
Ileal Crohn disease: mural microvascularity quantified with contrast-enhanced US correlates with disease activity.
Radiology., 262 (2012), pp. 680-688
[37]
A. Medellin, C.h Merrill, S.R. Wilson.
Contrast-enhanced ultrasound in the evaluation of the bowel.
Abdom Radiol, 43 (2017), pp. 918-933
[38]
R. Wilkens, R.H. Hagemann-Madsen, D.A. Peters, A.H. Nielsen, C.B. Norager, H. Glerup, et al.
Validity of Contrast-enhanced Ultrasonography and Dynamic Contrast-enhanced MR Enterography in the Assessment of Transmural Activity and Fibrosis in Crohn’s Disease.
J Crohns Colitis., 12 (2018), pp. 48-56
[39]
G. Maconi, S. Greco, P. Duca, S. Ardizzone, A. Massari, A. Cassinotti, et al.
Prevalence and clinical significance of sonographic evidence of mesenteric fat alterations in Crohn’s disease.
Inflamm Bowel Dis., 14 (2008), pp. 1555-1561
[40]
T. Kucharzik, B.M. Wittig, U. Helwig, N. Borner, A. Rossler, S. Rath, et al.
Use of Intestinal Ultrasound to Monitor Crohn’s Disease Activity.
Clin Gastroenterol Hepatol., 15 (2017),
[41]
C. Gasche, G. Moser, K. Turetschek, E. Schober, P. Moeschl, G. Oberhuber.
Transabdominal bowel sonography for the detection of intestinal complications in Crohn’s disease.
Gut., 44 (1999), pp. 112-117
[42]
H. Neye, D. Ensberg, P. Rauh, U. Peitz, K. Monkemuller, G. Treiber, et al.
Impact of high-resolution transabdominal ultrasound in the diagnosis of complications of Crohn’s disease.
Scand J Gastroenterol., 45 (2010), pp. 690-695
[43]
J. Sarrazin, S.R. Wilson.
Manifestations of Crohn disease at US.
Radiographics., 16 (1996), pp. 499-520
[44]
R. Di Mizio, G. Maconi, S. Romano, F. D’Amario, G. Bianchi Porro, R. Grassi.
Small bowel Crohn disease: sonographic features.
Abdom Imaging., 29 (2004), pp. 23-35
[45]
K. Nylund, T. Hausken, O.H. Gilja.
Ultrasound and inflammatory bowel disease.
Ultrasound quarterly, 26 (2010), pp. 3-15
[46]
N. Pallotta, G. Vincoli, C. Montesani, P. Chirletti, A. Pronio, R. Caronna, et al.
Small intestine contrast ultrasonography (SICUS) for the detection of small bowel complications in crohn’s disease: a prospective comparative study versus intraoperative findings.
Inflamm Bowel Dis., 18 (2012), pp. 74-84
[47]
G. Bhatnagar, C. Von Stempel, S. Halligan, S.A. Taylor.
Utility of MR enterography and ultrasound for the investigation of small bowel Crohn’s disease.
J Magn Reson Imaging., 45 (2017), pp. 1573-1588
[48]
M.J. Martinez, T. Ripolles, J.M. Paredes, E. Blanc, L. Marti-Bonmati.
Assessment of the extension and the inflammatory activity in Crohn’s disease: comparison of ultrasound and MRI.
Abdom Imaging., 34 (2009), pp. 141-148
[49]
S. Kumar, A. Hakim, C. Alexakis, V. Chhaya, D. Tzias, J. Pilcher, et al.
Small intestinal contrast ultrasonography for the detection of small bowel complications in Crohn’s disease: correlation with intraoperative findings and magnetic resonance enterography.
J Gastroenterol Hepatol., 30 (2015), pp. 86-91
[50]
T. Ripolles, M.J. Martinez-Perez, J.M. Paredes, J. Vizuete, E. Garcia-Martinez, D.H. Jimenez-Restrepo.
Contrast-enhanced ultrasound in the differentiation between phlegmon and abscess in Crohn’s disease and other abdominal conditions.
Eur J Radiol., 82 (2013), pp. e525-31
[51]
J. Panes, Y. Bouhnik, W. Reinisch, J. Stoker, S.A. Taylor, D.C. Baumgart, et al.
Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines.
J Crohns Colitis., 7 (2013), pp. 556-585
[52]
F. Rieder, G. Latella, F. Magro, E.S. Yuksel, P.D. Higgins, A. Di Sabatino, et al.
European Crohn’s and Colitis Organisation Topical Review on Prediction, Diagnosis and Management of Fibrostenosing Crohn’s Disease.
J Crohns Colitis., 10 (2016), pp. 873-885
[53]
C. Girlich, E.M. Jung, E. Huber, C. Ott, I. Iesalnieks, A. Schreyer, et al.
Comparison between preoperative quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and operative macroscopic findings and results of histopathological scoring in Crohn’s disease.
Ultraschall Med., 32 (2011), pp. 154-159
[54]
K. Nylund, R. Jirik, M. Mezl, S. Leh, T. Hausken, F. Pfeffer, et al.
Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn’s disease.
Ultrasound Med Biol., 39 (2013), pp. 1197-1206
[55]
E. Quaia, L. De Paoli, T. Stocca, B. Cabibbo, F. Casagrande, M.A. Cova.
The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn’s disease.
Ultrasound Med Biol., 38 (2012), pp. 1324-1332
[56]
T. Ripolles, N. Rausell, J.M. Paredes, E. Grau, M.J. Martinez, J. Vizuete.
Effectiveness of contrast-enhanced ultrasound for characterisation of intestinal inflammation in Crohn’s disease: a comparison with surgical histopathology analysis.
J Crohns Colitis., 7 (2013), pp. 120-128
[57]
A. Vestito, G. Marasco, G. Maconi, D. Festi, F. Bazzoli, R.M. Zagari.
Role of Ultrasound Elastography in the Detection of Fibrotic Bowel Strictures in Patients with Crohn’s Disease: Systematic Review and Meta-Analysis.
Ultraschall Med., 40 (2019), pp. 646-654
[58]
J.R. Dillman, S.F. Dehkordy, E.A. Smith, M.A. DiPietro, R. Sanchez, V. DeMatos-Maillard, et al.
Defining the ultrasound longitudinal natural history of newly diagnosed pediatric small bowel Crohn disease treated with infliximab and infliximab-azathioprine combination therapy.
Pediatr Radiol., 47 (2017), pp. 924-934
[59]
F. Saevik, K. Nylund, T. Hausken, S. Odegaard, O.H. Gilja.
Bowel perfusion measured with dynamic contrast-enhanced ultrasound predicts treatment outcome in patients with Crohn’s disease.
Inflamm Bowel Dis., 20 (2014), pp. 2029-2037
[60]
S.C. Shah, J.F. Colombel, B.E. Sands, N. Narula.
Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn’s disease.
Aliment Pharmacol Ther., 43 (2016), pp. 317-333
[61]
F. Castiglione, N. Imperatore, A. Testa, G.D. De Palma, O.M. Nardone, L. Pellegrini, et al.
One-year clinical outcomes with biologics in Crohn’s disease: transmural healing compared with mucosal or no healing.
Aliment Pharmacol Ther., 49 (2019), pp. 1026-1039
[62]
N. Moreno, T. Ripolles, J.M. Paredes, I. Ortiz, M.J. Martinez, A. Lopez, et al.
Usefulness of abdominal ultrasonography in the analysis of endoscopic activity in patients with Crohn’s disease: changes following treatment with immunomodulators and/or anti-TNF antibodies.
J Crohns Colitis., 8 (2014), pp. 1079-1087
[63]
F. Castiglione, P. Mainenti, A. Testa, N. Imperatore, G.D. De Palma, S. Maurea, et al.
Cross-sectional evaluation of transmural healing in patients with Crohn’s disease on maintenance treatment with anti-TNF alpha agents.
Dig Liver Dis., 49 (2017), pp. 484-489
[64]
P. Rutgeerts, K. Geboes, G. Vantrappen, J. Beyls, R. Kerremans, M. Hiele.
Predictability of the postoperative course of Crohn’s disease.
Gastroenterology., 99 (1990), pp. 956-963
[65]
E. Domenech, A. Lopez-Sanroman, P. Nos, M. Vera, M. Chaparro, M. Esteve, et al.
Recommendations of the Spanish Working Group on Crohn’s Disease and Ulcerative Colitis (GETECCU) on the monitoring, prevention and treatment of post-operative recurrence in Crohn’s disease.
Gastroenterol Hepatol., 40 (2017), pp. 472-483
[66]
E. Ercole, C. Rigazio.
Role of bowel ultrasound in the management of postoperative Crohn’s disease.
World J Gastrointest Pathophysiol., 5 (2014), pp. 457-461
[67]
J.M. Paredes, T. Ripolles, X. Cortes, N. Moreno, M.J. Martinez, M. Bustamante-Balen, et al.
Contrast-enhanced ultrasonography: usefulness in the assessment of postoperative recurrence of Crohn’s disease.
J Crohns Colitis., 7 (2013), pp. 192-201
[68]
A. Rispo, N. Imperatore, A. Testa, O.M. Nardone, G. Luglio, N. Caporaso, et al.
Diagnostic Accuracy of Ultrasonography in the Detection of Postsurgical Recurrence in Crohn’s Disease: A Systematic Review with Meta-analysis.
Inflamm Bowel Dis., 24 (2018), pp. 977-988
[69]
M.J. Martinez, T. Ripolles, J.M. Paredes, E. Moreno-Osset, J.M. Pazos, E. Blanc.
Intravenous Contrast-Enhanced Ultrasound for Assessing and Grading Postoperative Recurrence of Crohn’s Disease.
Dig Dis Sci., 64 (2019), pp. 1640-1650
[70]
J. Guardiola, T. Lobaton, E. Cerrillo, R. Ferreiro-Iglesias, J.P. Gisbert, E. Domenech, et al.
Recommendations of the Spanish Working Group on Crohn’s Disease and Ulcerative Colitis (GETECCU) on the utility of the determination of faecal calprotectin in inflammatory bowel disease.
Gastroenterol Hepatol., 41 (2018), pp. 514-529
[71]
A. Sturm, C. Maaser, E. Calabrese, V. Annese, G. Fiorino, T. Kucharzik, et al.
ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects.
J Crohns Colitis., 13 (2019), pp. 273-284
[72]
V. Arienti, M. Campieri, L. Boriani, P. Gionchetti, C. Califano, S. Giancane, et al.
Management of severe ulcerative colitis with the help of high resolution ultrasonography.
Am J Gastroenterol., 91 (1996), pp. 2163-2169
[73]
F. Civitelli, G. Di Nardo, S. Oliva, F. Nuti, F. Ferrari, A. Dilillo, et al.
Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, comparative study with colonoscopy.
[74]
M. Allocca, G. Fiorino, S. Bonovas, F. Furfaro, D. Gilardi, M. Argollo, et al.
Accuracy of Humanitas Ultrasound Criteria in Assessing Disease Activity and Severity in Ulcerative Colitis: A Prospective Study.
J Crohns Colitis., 12 (2018), pp. 1385-1391
[75]
A.S. Bavil, M.H. Somi, M. Nemati, B.S. Nadergoli, K. Ghabili, R. Mirnour, et al.
Ultrasonographic evaluation of bowel wall thickness and intramural blood flow in ulcerative colitis.
ISRN Gastroenterol., 2012 (2012),
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