Buscar en
Radiología (English Edition)
Toda la web
Inicio Radiología (English Edition) Hippocampal sclerosis: Volumetric evaluation of the substructures of the hippoca...
Journal Information
Vol. 60. Issue 5.
Pages 404-412 (September - October 2018)
Share
Share
Download PDF
More article options
ePub
Visits
3
Vol. 60. Issue 5.
Pages 404-412 (September - October 2018)
Original Report
DOI: 10.1016/j.rxeng.2018.07.003
Hippocampal sclerosis: Volumetric evaluation of the substructures of the hippocampus by magnetic resonance imaging
Esclerosis hipocampal: evaluación volumétrica de las subestructuras del hipocampo utilizando resonancia magnética
Visits
...
A.M. Granados Sánchez, J.F. Orejuela Zapata
Corresponding author
jforejuela@gmail.com

Corresponding author.
Departamento de Imágenes Diagnósticas, Fundación Valle de Lili, Universidad ICESI, Cali, Colombia
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (2)
Table 1. Volumetric indexes of hippocampal structures in patients with left HS and control subjects.
Table 2. Volumetric indexes of hippocampal substructures in patients with right hippocampal sclerosis and control subjects.
Show moreShow less
Abstract
Objective

The pathological classification of hippocampal sclerosis is based on the loss of neurons in the substructures of the hippocampus. This study aimed to evaluate these substructures in patients with hippocampal sclerosis by magnetic resonance imaging and to compare the usefulness of this morphological analysis compared to that of volumetric analysis of the entire hippocampus.

Material and methods

We included 25 controls and 25 patients with hippocampal sclerosis whose diagnosis was extracted from the institutional epilepsy board. We used FreeSurfer to process the studies and to obtain the volumetric data. We evaluated overall volume and volume by substructure: fimbria, subiculum, presubiculum, hippocampal sulcus, CA1, CA2–CA3, CA4, and dentate gyrus (DG). We considered p<0.05 statistically significant.

Results

We observed statistically significant decreases in the volume of the hippocampus ipsilateral to the epileptogenic focus in 19 (76.0%) of the 25 cases. With the exception of the hippocampal sulcus, we observed a decrease in all ipsilateral hippocampal substructures in patients with right hippocampal sclerosis (CA1, p=0.0223; CA2–CA3, p=0.0066; CA4–GD, p=0.0066; fimbria, p=0.0046; presubiculum, p=0.0087; subiculum, p=0.0017) and in those with left hippocampal sclerosis (CA1, p<0.0001; CA2–CA3, p<0.0001; CA4–GD, p<0.0001; fimbria, p=0.0183; presubiculum, p<0.0001; subiculum, p<0.0001). In four patients with left hippocampal sclerosis, none of the substructures had statistically significant alterations, although a trend toward atrophy was observed, mainly in CA2–CA3 and CA4–GD.

Conclusion

The findings suggest that it can be useful to assess the substructures of the hippocampus to improve the performance of diagnostic imaging in patients with hippocampal sclerosis.

Keywords:
Epilepsy
Magnetic resonance imaging
Hippocampus
Resumen
Objetivo

Evaluar las subestructuras hipocampales utilizando resonancia magnética en pacientes con esclerosis hipocampal (EH), comparando los resultados con el análisis morfológico y la volumetría global del hipocampo.

Método

Se incluyeron 25 controles y 25 pacientes con EH, cuyo diagnóstico fue extraído del informe de la junta institucional de epilepsia. Se utilizó FreeSurfer para el procesamiento de los estudios y la obtención de los datos volumétricos. El volumen fue valorado de manera global y por subestructura: fimbria, subiculum, presubiculum, fisura hipocampal, CA1, CA2-CA3, CA4 y giro dentado (GD). Se consideró p<0,05 como estadísticamente significativo.

Resultados

Se observó una disminución estadísticamente significativa en el hipocampo homolateral al foco epileptógeno en 19 de los 25 casos (76,0%). A excepción de la fisura hipocampal, se observó una disminución en todas las subestructuras hipocampales homolaterales en la EH derecha (CA1, p=0,0223; CA2–CA3, p=0,0066; CA4–GD, p=0,0066; fimbria, p=0,0046; presubiculum, p=0,0087; subiculum, p=0,0017) y la EH izquierda (CA1, p<0,0001; CA2–CA3, p<0,0001; CA4–GD, p<0,0001; fimbria, p=0,0183; presubiculum, p<0,0001; subiculum, p<0,0001). En cuatro casos de EH izquierda, ninguna de las subestructuras presentó alteración estadísticamente significativa; sin embargo, se observó una tendencia de atrofia, principalmente en CA2–CA3 y CA4–GD.

Conclusión

Los hallazgos sugieren la utilidad de la evaluación de las subestructuras hipocampales para mejorar el desempeño de la imagen en el diagnóstico de la EH.

Palabras clave:
Epilepsia
Resonancia magnética
Hipocampo

Article

These are the options to access the full texts of the publication Radiología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.