metricas

Radiología (English Edition)

Suggestions
Radiología (English Edition) Contrast agents for MR enterography
Journal Information
Vol. 66. Issue S2.
Suplement “Update and good practice in the contrast media uses”
Pages S1-S142 (October 2024)
Cite
Cite
Share
Download PDF
More article options
Visits
2957
Vol. 66. Issue S2.
Suplement “Update and good practice in the contrast media uses”
Pages S1-S142 (October 2024)
Update and good practice in the contrast media uses

Contrast agents for MR enterography

Contraste intestinal en resonancia magnética
Visits
2957
A. Álvarez-Cofiño Tuñón
Corresponding author
almuscofi@hotmail.com

Corresponding author.
, M. da Silva Torres, A. Fernández del Valle, P. Noriega Menéndez, R. Menéndez de Llano Ortega, P. González Filgueira
Sección de Radiología Abdominal, Servicio de Radiodiagnóstico, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Special issue
This article is part of special issue:
Vol. 66. Issue S2

Suplement “Update and good practice in the contrast media uses”

More info
Abstract

Magnetic resonance enterography is primarily indicated for inflammatory bowel diseases. The study of the gastrointestinal tract using MRI has become feasible due to the emergence of ultrafast sequences with higher spatial resolution and phased-array coils enabling wider fields of view. However, to ensure the quality of the examination, it is essential to have prior preparation with oral or rectal contrast to distend the lumen and improve the definition of the intestinal wall. These contrast agents can be positive, negative or biphasic, depending on the signal intensity they induce in the intestinal lumen. Most commonly used biphasic contrasts agents behave as hyperintense in T2 and hypointense in T1. Achieving a “black” intestinal lumen in 3D T1-weighted sequences with intravenous contrast injection is crucial for mucosal assessment and parietal enhancement. Although more cost-effective and accessible, biphasic agents like PEG and mannitol are relatively discomforting for patients. While negative agents are preferred, they are currently unavailable. The purpose of this article is to review the different types of contrast agents mentioned in the literature and their application in intestinal resonance, analyzing the effects they generate on the image, their possible indications and associated limitations.

Keywords:
Magnetic resonance enterography
Inflammatory bowel diseases
Gastrointestinal imaging
Enteral contrast agents
Crohn’s disease
Biphasic contrast agents
Resumen

La enterografía por Resonancia Magnética está principalmente indicada en la enfermedad inflamatoria intestinal. El estudio del tracto gastrointestinal mediante resonancia hoy día es posible gracias a la aparición de secuencias ultrarrápidas con mayor resolución espacial y bobinas phased-array que permiten campos de visión de todo el abdomen. Sin embargo, para garantizar la calidad de la exploración es fundamental una preparación previa con contraste oral o rectal para distender la luz y mejorar la definición de la pared intestinal. Estos agentes de contraste pueden ser positivos, negativos o bifásicos, dependiendo de la señal que generen en la luz intestinal. Los contrastes bifásicos son los más empleados en la práctica diaria y se comportan como hiperintensos en T2 e hipointensos en T1. Lograr una luz intestinal "negra" en secuencias 3D ponderadas en T1 con inyección intravenosa de contraste es crucial para la evaluación de la mucosa y el realce parietal. Aunque son más económicos y accesibles, los agentes bifásicos como el PEG y el manitol son relativamente molestos para los pacientes. Los agentes negativos son los más deseados, pero no están disponibles de manera rutinaria. El propósito de este artículo es revisar los diferentes tipos de contrastes mencionados en la literatura para su aplicación en resonancia intestinal, analizando los efectos que generan en la imagen, sus posibles indicaciones y limitaciones asociadas.

Palabras clave:
Enterografía por resonancia magnética
Enfermedad inflamatoria intestinal
Imagen gastrointestinal
Medios de contraste enteral
Enfermedad de Crohn
Contrastes bifásicos

Article

These are the options to access the full texts of the publication Radiología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
References
[1]
JF Debatin, MA Patak.
MRI of the small and large bowel.
Eur Radiol, 9 (1999), pp. 1523-1534
[2]
F. Maccioni, A. Viscido, L. Broglia, M. Marrollo, R. Masciangelo, R. Caprilli, et al.
Evaluation of Crohn disease activity with magnetic resonance imaging.
Abdom Imaging, 25 (2000), pp. 219-228
[3]
L. Martí-Bonmatí, M. Graells, C.L. Ronchera-Oms.
Reduction of peristaltic artifacts on magnetic resonance imaging of the abdomen: a comparative evaluation of three drugs.
Abdom Imaging, 21 (1996), pp. 309-313
[4]
A. Torregrosa, Y. Pallardó, J. Hinojosa, S. Insa, R. Molina.
Magnetic resonance enterography: technique and indications. Findings in Crohn’s disease.
Radiologia, 55 (2013), pp. 422-430
[5]
J. Makanyanga, S. Punwani, S.A. Taylor.
Assessment of wall inflammation and fibrosis in Crohn’s disease: value of T1-weighted gadolinium-enhanced MR imaging.
Abdom Imaging, 37 (2012), pp. 933-943
[6]
D.M. Koh, Y. Miao, R.J. Chinn, Z. Amin, R. Zeegen, D. Westaby, et al.
MR imaging evaluation of the activity of Crohn’s disease.
AJR Am J Roentgenol, 177 (2001), pp. 1325-1332
[7]
G.A.J. Sempere, V. Martinez Sanjuan, E. Medina Chulia, A. Benages, A. Tome Toyosato, P. Canelles, et al.
MRI evaluation of inflammatory activity in Crohn’s disease.
AJR Am J Roentgenol, 184 (2005), pp. 1829-1835
[8]
A. Giovagnoni, A. Fabbri, F. Maccioni.
Oral contrast agents in MRI of the gastrointestinal tract.
Abdom Imaging, 27 (2002), pp. 367-375
[9]
K.E. Jacobs, D. Behera, J. Rosenberg, G. Gold, M. Moseley, D. Yeomans, et al.
Oral manganese as an MRI contrast agent for the detection of nociceptive activity.
NMR Biomed, 25 (2012), pp. 563-569
[10]
O.J. Arthurs, M.J. Graves, A.D. Edwards, I. Joubert, P.A.K. Set, D.J. Lomas.
Interactive neonatal gastrointestinal magnetic resonance imaging using fruit juice as an oral contrast media.
BMC Med Imaging, 14 (2014), pp. 33
[11]
K.C. Li, R.P. Tart, J.R. Fitzsimmons, B.L. Storm, J. Mao, R.J. Rolfes.
Barium sulfate suspension as a negative oral MRI contrast agent: in vitro and human optimization studies.
Magn Reson Imaging, 9 (1991), pp. 141-150
[12]
P.F. Hahn, D.D. Stark, J.M. Lewis, S. Saini, G. Elizondo, R. Weissleder, et al.
First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging.
Radiology, 175 (1990), pp. 695-700
[13]
S. Kaminsky, M. Laniado, M. Gogoll, W. Kornmesser, W. Clauss, M. Langer, et al.
Gadopentetate dimeglumine as a bowel contrast agent: safety and efficacy.
Radiology, 178 (1991), pp. 503-508
[14]
T.H.P. Rijcken, M.A. Davis, P.R. Ros.
Intraluminal contrast agents for MR imaging of the abdomen and pelvis.
J Magn Reson Imaging, 4 (1994), pp. 291-300
[15]
J. Wahsner, E.M. Gale, A. Rodríguez-Rodríguez, P. Caravan.
Chemistry of MRI contrast agents: current challenges and new frontiers.
Chem Rev, 119 (2019), pp. 957-1057
[16]
N.M. Elsayed, S.A. Alsalem, S.A.A. Almugbel, M.M. Alsuhaimi.
Effectiveness of natural oral contrast agents in magnetic resonance imaging of the bowel.
Egypt J Radiol Nucl Med, 46 (2015), pp. 287-292
[17]
F. Maccioni, L. Busato, A. Valenti, S. Cardaccio, A. Longhi, C. Catalano.
Magnetic resonance imaging of the gastrointestinal tract: current role, recent advancements and future prospectives.
Diagn Basel Switz, 13 (2023), pp. 2410
[18]
J. Rimola, I. Ordás, S. Rodriguez, O. García-Bosch, M. Aceituno, J. Llach, et al.
Magnetic resonance imaging for evaluation of Crohnʼs disease: validation of parameters of severity and quantitative index of activity.
Inflamm Bowel Dis, 17 (2011), pp. 1759-1768
[19]
P. Lafeuille, C. Hordonneau, J. Vignette, L. Blayac, M. Dapoigny, M. Reymond, et al.
Transmural healing and MRI healing are associated with lower risk of bowel damage progression than endoscopic mucosal healing in Crohn’s disease.
Aliment Pharmacol Ther, 53 (2021), pp. 577-586
[20]
S.A. Taylor, S. Mallett, G. Bhatnagar, R. Baldwin-Cleland, S. Bloom, A. Gupta, et al.
Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial.
Lancet Gastroenterol Hepatol, 3 (2018), pp. 548-558
[21]
J. Rimola, S. Rodríguez, O. García-Bosch, E. Ricart, M. Pagès, M. Pellisé, et al.
Role of 3.0-T MR colonography in the evaluation of inflammatory bowel disease.
Radiogr Rev Publ Radiol Soc N Am Inc, 29 (2009), pp. 701-719
[22]
M.P. van der Paardt, J. Stoker.
Current status of magnetic resonance colonography for screening and diagnosis of colorectal cancer.
Radiol Clin North Am, 56 (2018), pp. 737-749
[23]
A. Frisch, T.C. Walter, C. Grieser, D. Geisel, B. Hamm, T. Denecke.
Performance survey on a new standardized formula for oral signal suppression in MRCP.
Eur J Radiol Open, 5 (2018), pp. 1-5
[24]
T.B. Brismar, D. Geisel, N. Kartalis, B.L. Madrazo, H. Persson Hedman, A Norlin.
Oral manganese chloride tetrahydrate: a novel magnetic resonance liver imaging agent for patients with renal impairment: efficacy, safety, and clinical implication.
Invest Radiol, 59 (2024), pp. 197-205
[25]
L. Herraiz Hidalgo, E. Alvarez Moreno, J. Carrascoso Arranz, R. Cano Alonso, V. Martínez de Vega Fernández.
Entero-resonancia magnética: revisión de la técnica para el estudio de la enfermedad de Crohn.
Radiología, 53 (2011), pp. 421-433
[26]
J. Rimola, A. Alvarez-Cofiño, T. Pérez-Jeldres, S. Rodríguez, I. Alfaro, I. Ordás, et al.
Increasing efficiency of MRE for diagnosis of Crohn’s disease activity through proper sequence selection: a practical approach for clinical trials.
Abdom Radiol N Y, 42 (2017), pp. 2783-2791
[27]
E. Ripoll Fuster, S. Rodríguez Gómez, Á Soler Perromat, M.J. Moreno, J. Rimola Gibert.
El informe radiológico en la enfermedad de Crohn.
Radiología, 64 (2022), pp. 69-76
[28]
E. Thornton, M.M. Morrin, J. Yee.
Current status of MR colonography.
RadioGraphics, 30 (2010), pp. 201-218
asdasdasd
Article options
Tools