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array:21 [ "pii" => "S266704962100079X" "issn" => "26670496" "doi" => "10.1016/j.neurop.2021.11.003" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "59" "copyright" => "Sociedad Española de Neurología" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S2667049621000636" "issn" => "26670496" "doi" => "10.1016/j.neurop.2021.07.007" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "46" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "The challenges of the bioactive scaffolds in nervous system: From their molecular conformation to their therapeutic efficiency" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S3" "paginaFinal" => "S18" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Los retos de los andamios bioactivos en el sistema nervioso: de la conformación molecular a su efectividad terapéutica" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "f0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 700 "Ancho" => 1949 "Tamanyo" => 201645 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Schematic representation of the two main tissue engineering bioactive scaffold strategies used to present bioactive compounds/signalling molecules (Growth factors, mitogens, morphogens) to host tissue in order to promote tissue regeneration. (A) Physical encapsulation of the growth factors in the delivery system. This strategy will achieve an in-demand release of the signalling molecules to the surrounding tissue. (B) Chemical immobilisation of the growth factor into or onto the matrix. This involves the affinity or chemical interactions between the growth-factor-containing polymer substrate and the surrounding tissue.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Ramos-Zúñiga, I. Segura-Duran, R.E. González-Castañeda, J.A. González Rios" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Ramos-Zúñiga" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Segura-Duran" ] 2 => array:2 [ "nombre" => "R.E." "apellidos" => "González-Castañeda" ] 3 => array:2 [ "nombre" => "J.A." "apellidos" => "González Rios" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2667049621000636?idApp=UINPBA00004N" "url" => "/26670496/00000002000000S1/v4_202403290506/S2667049621000636/v4_202403290506/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Biomaterial- and stem cell–based treatment strategies for diseases of the central nervous system" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S1" "paginaFinal" => "S2" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Canales-Aguirre, J.C. Mateos-Díaz, J. Matias-Guiu, U. Gomez-Pinedo" "autores" => array:4 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Canales-Aguirre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "af0010" ] ] ] 1 => array:3 [ "nombre" => "J.C." "apellidos" => "Mateos-Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "af0015" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Matias-Guiu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "af0020" ] ] ] 3 => array:4 [ "nombre" => "U." "apellidos" => "Gomez-Pinedo" "email" => array:1 [ 0 => "u.gomez.pinedo@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cr0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Neurology, Laboratory of Neurobiology, Institute of Neurosciences, San Carlos Health Research Institute, Universidad Complutense, Spain" "etiqueta" => "a" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Preclinical Evaluation Unit, Medical and Pharmaceutical Biotechnology Unit. CIATEJ-CONACyT, Guadalajara, Mexico" "etiqueta" => "b" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Department of Industrial Biotechnology, CIATEJ-CONACyT, Guadalajara, Mexico" "etiqueta" => "c" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Department of Neurology, Institute of Neurosciences, San Carlos Health Research Institute, Universidad Complutense, Madrid, Spain" "etiqueta" => "d" "identificador" => "af0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estrategias terapéuticas basadas en biomateriales y células madre en patologías del sistema nervioso central" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="p0005" class="elsevierStylePara elsevierViewall">The research topic “Biomaterial- and stem cell– based treatment strategies for diseases of the central nervous system,” including 7 articles, seeks to underscore the importance of translational research in the area of cell therapy and tissue engineering.</p><p id="p0010" class="elsevierStylePara elsevierViewall">Today, the generation of novel treatment strategies for diseases of the central nervous system, such as vascular (stroke, hypoxia), oncological (gliomas), infectious, or neurodegenerative diseases (Parkinson's disease, amyotrophic lateral sclerosis, etc.), has created new areas of research involving close collaboration between the fields of basic and clinical research.</p><p id="p0015" class="elsevierStylePara elsevierViewall">The path forward is promising, and bioengineering is evolving day by day, with the development of new materials biocompatible with nervous tissue, enabling the design of in vitro systems to study pathophysiological mechanisms in tumoural or infectious diseases of the nervous system. As well as serving as a platform for the development of personalised in vitro models of complex diseases, these models also help elucidate their structural formation and cell-biomaterial integration, as a basis for the future development of biomaterials preloaded with pluripotent stem cells or as vehicles for drugs and bioactive compounds. The development of these constructs aims to promote endogenous restoration of neural tissue lesions and to promote axonal connection.<a class="elsevierStyleCrossRefs" href="#bb0005"><span class="elsevierStyleSup">1–4</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">Alongside the development of tissue engineering, cell therapy has evolved over the last 3 decades, seeking new ways to restore or promote regeneration, cell plasticity, or the action of implanted cells as small trophic pumps in such lesions as stroke, hypoxia, spinal injury, and gliomas. One of the most successful strategies, as evidenced by the number of clinical and preclinical trials, is the use of mesenchymal stem cells, which have shown benefits and therapeutic potential in diseases involving inflammatory mechanisms, such as stroke and neonatal hypoxia.<a class="elsevierStyleCrossRef" href="#bb0025"><span class="elsevierStyleSup">5</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">In the context of neurodegenerative disease, such as Parkinson's disease, several study groups have explored the potential of a range of cell types to increase the number of dopaminergic neurons and to promote their projections to the striatum, or as trophic pumps to increase baseline dopamine levels, as has already been demonstrated with the implantation of cells from the carotid body. Furthermore, several preclinical trials have used biomaterial bridges preloaded with glial or stem cells to promote or orient axonal projections from the substantia nigra to the striatum, with promising results.<a class="elsevierStyleCrossRef" href="#bb0030"><span class="elsevierStyleSup">6</span></a></p><p id="p0030" class="elsevierStylePara elsevierViewall">Finally, cell therapy with mesenchymal stem cells is a promising strategy in amyotrophic lateral sclerosis, and has been demonstrated to modulate inflammation and delay the onset of symptoms of the disease.<a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a></p><p id="p0035" class="elsevierStylePara elsevierViewall">We are confident that the path forward in this area of biomedical research may generate more projects and greater interest in the scientific community through synergy between different disciplines, benefiting the population in the short term.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-11-24" "fechaAceptado" => "2021-11-30" "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="p7275" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="ec0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "s7145" ] ] ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "ec0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0030" "detalle" => "Image " "rol" => "short" ] ] "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 162538 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The challenges of the bioactive scaffolds in nervous system: From their molecular conformation to their therapeutic efficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Ramos-Zúñiga" 1 => "I. Segura-Duran" 2 => "R.E. González-Castañeda" 3 => "J.A. González-Rios" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neurop.2021.07.007" "Revista" => array:2 [ "tituloSerie" => "Neurology Perspectives" "fecha" => "2021" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ortho-coumaric acid derivatives with therapeutic potential in a three-dimensional culture of the immortalised U-138 MG glioblastoma multiforme cell line" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "Y.K. Gutiérrez-Mercadoa" 1 => "J.C. Mateos-Díaz" 2 => "D.D. Ojeda-Hernándezb" 3 => "F.J. López-Gonzalez" 4 => "E.E. Reza-Zaldivard" 5 => "M.A. Hernández-Sapiens" 6 => "U.A. Gómez-Pinedo" 7 => "R.S. Estrada" 8 => "M. Macías-Carballo" 9 => "A.A. Canales-Aguirre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neurop.2021.09.006" "Revista" => array:2 [ "tituloSerie" => "Neurology Perspectives" "fecha" => "2021" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biomaterials: Emerging systems for study and treatment of Glioblastoma Multiforme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.R. Aguilera-Márquez" 1 => "G. Tonantzin de Dios Figueroa" 2 => "E.E. Reza-Saldivar" 3 => "T.A. Camacho-Villegas" 4 => "A.A. Canales-Aguirre" 5 => "P. 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Potential therapeutic applications of stem cell therapy for neonatal hypoxic-ischaemic brain injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. del Pozo" 1 => "M. Villa" 2 => "J. Martínez-Orgado" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neurop.2021.07.004" "Revista" => array:2 [ "tituloSerie" => "Neurology Perspectives" "fecha" => "2021" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Parkinson's disease: Present and future of cell therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.J. Sancho-Bielsa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neurop.2021.07.006" "Revista" => array:2 [ "tituloSerie" => "Neurology Perspectives" "fecha" => "2021" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cell therapy as therapeutic strategy in Amyotrophic Lateral Sclerosis. Gomez-Pinedo, L. Moreno-Jiménez, M.S. Benito-Martín, A. Abad-Fernández, B. Selma-Calvo, N. Fernandez-Cucho, J. A. Matias-Guiu, L. Galán-Dávila, A. Guerrero-Sola, J. Matías-Guiu." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/26670496/00000002000000S1/v4_202403290506/S266704962100079X/v4_202403290506/en/main.assets" "Apartado" => array:4 [ "identificador" => "91016" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/26670496/00000002000000S1/v4_202403290506/S266704962100079X/v4_202403290506/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266704962100079X?idApp=UINPBA00004N" ]
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