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Inicio Medicina Clínica (English Edition) Whole body FDG-PET/CT for the assessment of bone marrow infiltration in patients...
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Vol. 154. Issue 2.
Pages 61-65 (January 2020)
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Vol. 154. Issue 2.
Pages 61-65 (January 2020)
Review
DOI: 10.1016/j.medcle.2019.07.005
Whole body FDG-PET/CT for the assessment of bone marrow infiltration in patients with newly diagnosed lymphoma
FDG-PET/TC de cuerpo entero para evaluar la infiltración de la médula ósea en pacientes con linfoma de nuevo diagnóstico
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Wang Xiao-Xue1, Huang Xinyue1, Zhang Lijun
Corresponding author
lzhang202003@163.com

Corresponding author.
Department of Hematology, the First Hospital, China Medical University, Shenyang 110001, China
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Tables (3)
Table 1. Patient characteristics.
Table 2. Consistency analysis of bone marrow biopsy and PET–CT.
Table 3. Correlation analysis of bone marrow biopsy and PET–CT in various pathological types of lymphoma.
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Additional material (1)
Abstract
Background

Positron emission tomography–computed tomography (PET–CT) and bone marrow biopsy are currently the common clinical examination of lymphoma infiltration. The aim of this research is to evaluate the value of PET–CT in diagnosis of bone marrow infiltration, clinical staging and pathological typing of lymphoma.

Methods

153 cases were analyzed retrospectively to compare the consistency of PET–CT and bone marrow biopsy. We analyzed the sensitivity, accuracy and specificity of PET–CT in different clinical pathology of lymphoma.

Results

The PET–CT sensitivity in detecting bone marrow infiltration is 54.3% with a specificity of 80.5% and accuracy of 74.5%. In aggressive B-cell lymphoma (DLBCL, HG-BL) and MZL, PET–CT results of bone marrow infiltration showed high accuracy of 88.1% and 83.3% respectively. The median value of SUVmax in the patients detected to have bone marrow infiltration by BMB was significantly higher than patients with BMB negative results among subgroups of aggressive B-cell lymphoma, MZL and T-NHL (p<.05).

Conclusion

PET–CT is significant in detecting bone marrow infiltration in certain pathological types of lymphoma. However pathological inconsistencies still exist between bone marrow biopsy and PET–CT, thus PET–CT cannot completely replace biopsy.

Keywords:
Lymphoma
PET–CT
SUVmax
Bone marrow infiltration
Ann Arbor stage
Resumen
Antecedentes

La tomografía computarizada por emisión de positrones (PET/TC) y la biopsia de médula ósea (BMB) son actualmente los exámenes clínicos comunes para valorar la infiltración linfomatosa. El objetivo de este estudio es evaluar el valor de la PET/TC en el diagnóstico de la infiltración de la médula ósea, la estadificación clínica y la tipificación patológica del linfoma.

Métodos

Se analizaron retrospectivamente 153 casos para comparar la consistencia de la PET/TC y la BMB. Analizamos la sensibilidad, la fiabilidad y la especificidad de la PET/TC en las diferentes enfermedades clínicas del linfoma.

Resultados

La sensibilidad de la PET/TC para detectar infiltración de la médula ósea es del 54,3%, con una especificidad del 80,5% y una precisión del 74,5%. En los casos de linfoma agresivo de células B (DLBCL, HG-BL) y MZL, los resultados de la PET/TC para la infiltración de la médula ósea reflejaron una alta precisión del 88,1 y 83,3%, respectivamente. El valor medio SUVmáx en los pacientes en los que se detectó infiltración de la médula ósea mediante BMB fue significativamente superior al de los pacientes con resultados negativos de BMB entre los subgrupos de linfoma agresivo de células B, MZL y T-NHL (p<0,05).

Conclusión

La PET/TC es significativa a la hora de detectar infiltración de la médula ósea en ciertos tipos patológicos de linfoma. Sin embargo, siguen existiendo inconsistencias patológicas entre la biopsia de médula ósea y la PET/TC, aunque esta técnica no puede sustituir por completo a la biopsia.

Palabras clave:
Linfoma
PET/TC
SUVmáx
Infiltración de la médula ósea
Estadificación de Ann Arbor

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