Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Whole body FDG-PET/CT for the assessment of bone marrow infiltration in patients...
Journal Information
Vol. 154. Issue 2.
Pages 61-65 (January 2020)
Download PDF
More article options
Vol. 154. Issue 2.
Pages 61-65 (January 2020)
Whole body FDG-PET/CT for the assessment of bone marrow infiltration in patients with newly diagnosed lymphoma
FDG-PET/TC de cuerpo entero para evaluar la infiltración de la médula ósea en pacientes con linfoma de nuevo diagnóstico
Wang Xiao-Xue1, Huang Xinyue1, Zhang Lijun
Corresponding author

Corresponding author.
Department of Hematology, the First Hospital, China Medical University, Shenyang 110001, China
Article information
Full Text
Download PDF
Tables (3)
Table 1. Patient characteristics.
Table 2. Consistency analysis of bone marrow biopsy and PET–CT.
Table 3. Correlation analysis of bone marrow biopsy and PET–CT in various pathological types of lymphoma.
Show moreShow less
Additional material (1)

Positron emission tomography–computed tomography (PET–CT) and bone marrow biopsy are currently the common clinical examination of lymphoma infiltration. The aim of this research is to evaluate the value of PET–CT in diagnosis of bone marrow infiltration, clinical staging and pathological typing of lymphoma.


153 cases were analyzed retrospectively to compare the consistency of PET–CT and bone marrow biopsy. We analyzed the sensitivity, accuracy and specificity of PET–CT in different clinical pathology of lymphoma.


The PET–CT sensitivity in detecting bone marrow infiltration is 54.3% with a specificity of 80.5% and accuracy of 74.5%. In aggressive B-cell lymphoma (DLBCL, HG-BL) and MZL, PET–CT results of bone marrow infiltration showed high accuracy of 88.1% and 83.3% respectively. The median value of SUVmax in the patients detected to have bone marrow infiltration by BMB was significantly higher than patients with BMB negative results among subgroups of aggressive B-cell lymphoma, MZL and T-NHL (p<.05).


PET–CT is significant in detecting bone marrow infiltration in certain pathological types of lymphoma. However pathological inconsistencies still exist between bone marrow biopsy and PET–CT, thus PET–CT cannot completely replace biopsy.

Bone marrow infiltration
Ann Arbor stage

La tomografía computarizada por emisión de positrones (PET/TC) y la biopsia de médula ósea (BMB) son actualmente los exámenes clínicos comunes para valorar la infiltración linfomatosa. El objetivo de este estudio es evaluar el valor de la PET/TC en el diagnóstico de la infiltración de la médula ósea, la estadificación clínica y la tipificación patológica del linfoma.


Se analizaron retrospectivamente 153 casos para comparar la consistencia de la PET/TC y la BMB. Analizamos la sensibilidad, la fiabilidad y la especificidad de la PET/TC en las diferentes enfermedades clínicas del linfoma.


La sensibilidad de la PET/TC para detectar infiltración de la médula ósea es del 54,3%, con una especificidad del 80,5% y una precisión del 74,5%. En los casos de linfoma agresivo de células B (DLBCL, HG-BL) y MZL, los resultados de la PET/TC para la infiltración de la médula ósea reflejaron una alta precisión del 88,1 y 83,3%, respectivamente. El valor medio SUVmáx en los pacientes en los que se detectó infiltración de la médula ósea mediante BMB fue significativamente superior al de los pacientes con resultados negativos de BMB entre los subgrupos de linfoma agresivo de células B, MZL y T-NHL (p<0,05).


La PET/TC es significativa a la hora de detectar infiltración de la médula ósea en ciertos tipos patológicos de linfoma. Sin embargo, siguen existiendo inconsistencias patológicas entre la biopsia de médula ósea y la PET/TC, aunque esta técnica no puede sustituir por completo a la biopsia.

Palabras clave:
Infiltración de la médula ósea
Estadificación de Ann Arbor


These are the options to access the full texts of the publication Medicina Clínica (English Edition)

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Medicina Clínica (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
Supplemental materials
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos