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Inicio Medicina Clínica (English Edition) Trabecular bone score and 25-hydroxyvitamin D levels in microvascular complicati...
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Vol. 158. Issue 7.
Pages 308-314 (April 2022)
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Vol. 158. Issue 7.
Pages 308-314 (April 2022)
Original article
Trabecular bone score and 25-hydroxyvitamin D levels in microvascular complications of type 2 diabetes mellitus
Índice trabecular óseo y niveles de 25-hidroxivitamina D en las complicaciones microvasculares de la diabetes mellitus tipo 2
Meryam Maamar el Asria, Emilio Pariente Rodrigoa,
Corresponding author

Corresponding author.
, Sara Díaz-Salazar de la Flora, Stefanie Pini Valdiviesob, M. Carmen Ramos Barrónc, José M. Olmos Martínezd, José L. Hernández Hernándezd
a Centro de Salud Camargo-Interior, Universidad de Cantabria, Santander, Spain
b Servicio de Hospitalización Domiciliaria, Hospital Universitario Marqués de Valdecilla, Santander, Spain
c Centro de Salud Camargo-Costa, Universidad de Cantabria, Santander, Spain
d Servicio de Medicina Interna, Unidad de Metabolismo Óseo, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain
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Figures (4)
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Tables (2)
Table 1. Clinical characteristics of the patients of the sample.
Table 2. Parameters related to bone metabolism in the patients of the sample.
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Background and objective

Diabetic microvascular disease (MVD) has been associated with increased bone fragility. The objective was to analyse the relationship between MVD and trabecular microstructure – assessed by the trabecular bone score (TBS) – in type 2 diabetic (T2D) patients. A second aim was to know the relationship between vitamin D and MVD.

Patients and methods

Cross-sectional study, which included men >50 years and postmenopausal women participating in a population-based cohort, diagnosed with T2D. The presence of nephropathy, neuropathy and/or retinopathy was classified as MVD+. Clinical and laboratory variables, TBS, 25(OH)D and BMD by DXA, were evaluated. Bivariate and multivariate analysis were performed.


We evaluated 361 patients (51.1% women), 63.8 (9) years old. Of them, 92 were MVD+ and presented poorer metabolic control, longer duration of T2D, lower TBS [1.235 (0.1) vs. 1.287 (0.1); p = 0.007] and lower levels of 25(OH)D [18.3 (7) vs. 21.6 (8) ng/mL; p = 0.0001). There were no differences between MVD+ and MVD− with regard to BMD or P1NP and β-CTX markers. After adjusting for confounders, including HbA1c and duration of T2D, the TBS value in MVD+ was 1.252 (95% CI 1.230–1.274) vs. 1.281 (95% CI 1.267–1.295) in MVD− (p = 0.034). MVD was associated with a 25(OH)D level <20 ng ml with an adjusted OR of 1.88 (95% CI 1.06–3.31; p = 0.028).


The MVD+ patients presented a significantly lower TBS, after adjusting for confounders. Furthermore, multivariable analysis showed a significant relationship between a low 25(OH)D level and a prevalent MVD.

Diabetic microangiopathy
Type 2 diabetes mellitus
Trabecular bone score
25-hydroxyvitamin D
Vitamin D deficiency
Bone metabolic diseases
Antecedentes y objetivo

La enfermedad microvascular (EMV) diabética ha sido asociada con una fragilidad ósea incrementada. El objetivo fue analizar la relación entre la EMV y la microestructura trabecular – evaluada mediante el índice trabecular óseo (trabecular bone score, TBS) – en pacientes diabéticos tipo 2 (DM2). Adicionalmente, conocer la relación entre la vitamina D y la EMV.

Pacientes y métodos

Diseño transversal analítico, que incluyó varones > 50 años y mujeres postmenopáusicas con DM2, participantes en una cohorte poblacional. Se clasificó como EMV+ la presencia de nefropatía, neuropatía y/o retinopatía. Fueron analizadas variables clínicas, de laboratorio, el TBS, la 25-hidroxivitamina D [25(OH)D] y la densidad mineral ósea (DMO). Se realizaron análisis bivariable y multivariable.


Fueron evaluados 361 pacientes (51,1% mujeres), de 63,8 (9) años. De ellos, 92 tenían EMV, con un peor control metabólico, mayor duración de la DM2, menor TBS (1,235 [0,1] vs. 1,287 [0,1]; p = 0,003) y menores niveles de 25(OH)D (18,3 [7] vs. 21,6 [8] ng/mL; p = 0,0001). No hubo diferencias entre EMV+ y EMV− en la DMO ni en los marcadores P1NP y β-CTX. Tras ajustar por confusores, incluyendo HbA1c y duración de la DM2, el TBS en EMV+ fue 1,252 (IC 95% 1,230–1,274) vs. 1,281 (IC 95% 1,267–1,295) en EMV− (p = 0,034). La EMV se asoció a un nivel de 25(OH)D < 20 ng/mL con una OR ajustada = 1,88 (IC 95% 1,06–3,31; p = 0,028).


Los pacientes con EMV presentaron un TBS significativamente menor, tras ajustar por confusores. El análisis multivariable mostró asimismo una asociación significativa entre un nivel bajo de 25(OH)D y la EMV prevalente.

Palabras clave:
Microangiopatía diabética
Diabetes mellitus tipo 2
Índice trabecular óseo
25-hidroxivitamina D
Deficiencia de vitamina D
Enfermedades metabólicas óseas


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