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Inicio Medicina Clínica (English Edition) TNF-alpha inhibition could reduce biomarkers of endothelial dysfunction in patie...
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Vol. 150. Issue 12.
Pages 465-468 (June 2018)
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Vol. 150. Issue 12.
Pages 465-468 (June 2018)
Original article
TNF-alpha inhibition could reduce biomarkers of endothelial dysfunction in patients with moderate to severe psoriasis: A 52-week echo-Doppler based quasi-experimental study
La inhibición del TNF-α puede disminuir los biomarcadores de disfunción endotelial en pacientes con psoriasis de moderada-grave: un estudio cuasiexperimental eco doppler a 52 semanas
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Alejandro Molina-Leyvaa, Fermín Garrido-Parejab, José Carlos Ruiz-Carrascosaa, Ricardo Ruiz-Villaverdea,
Corresponding author
ismenios@hotmail.com

Corresponding author.
a Departamento de Dermatología, Complejo Hospitalario Universitario de Granada, Granada, Spain
b Departamento de Radiología, Complejo Hospitalario Universitario de Granada, Granada, Spain
Article information
Abstract
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Table 1. Baseline characteristics of participants.
Abstract
Objectives

Psoriasis is associated to endothelial dysfunction, which causes impaired vascular functioning. TNF-α blockers have shown the ability to improve vascular functioning in psoriasis. The nailfold vessel resistance index (NVRI) assesses microvascular functioning at nailfold. The objectives of the study are to assess the effect of the TNF-α inhibition with adalimumab on NVRI.

Material and methods

Quasi-experimental study. Fifteen patients with moderate-severe psoriasis received adalimumab 40mg sc according to label information. Participants were assessed at baseline and at 12, 24 and 52 weeks after study intervention.

Results

A reduction of −0.09±0.02 (p<.01) in NVRI and a −11.2±2.41ng/ml (p<.001) in E-selectin was observed at week 52.

Conclusions

Adalimumab could produce a progressive and sustained reduction of vessel resistance at nailfold and E-selectin in patients with psoriasis.

Keywords:
Microvessels
Nails/blood supply
Psoriasis
Ultrasonography
Doppler
Vascular resistance
Adalimumab
Resumen
Objetivos

La psoriasis se asocia a la disfunción endotelial, lo cual provoca un deterioro del funcionamiento vascular. Los inhibidores del TNF-α han mostrado la capacidad de mejorar el funcionamiento vascular en la psoriasis. El índice de resistencia de los vasos ungueales (IRVU) evalúa el funcionamiento microvascular en la uña. El objetivo del estudio fue evaluar el efecto de la inhibición del TNF-α con adalimumab en el IRVU.

Material y métodos

Estudio cuasiexperimental. Quince pacientes con psoriasis moderada-grave recibieron adalimumab 40mg sc según ficha técnica. Se valoró a los participantes al inicio y a las 12, 24 y 52 semanas tras la intervención del estudio.

Resultados

En la semana 52 se observó una reducción del IRVU de −0,09±0,02 (p<0,01) y de −11,2±2,41ng/ml (p<0,001) en la E-selectina.

Conclusiones

Adalimumab podría producir una reducción progresiva y sostenida de la resistencia de los vasos ungueales y marcadores de disfunción endotelial.

Palabras clave:
Microvascularización
Uñas/aporte sanguíneo
Psoriasis
Ecografía
Doppler
Resistencia vascular
Adalimumab

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