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Inicio Medicina Clínica (English Edition) Second neoplasms in adult patients submitted to haematopoietic stem cell transpl...
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Vol. 150. Issue 11.
Pages 421-427 (June 2018)
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Vol. 150. Issue 11.
Pages 421-427 (June 2018)
Original article
Second neoplasms in adult patients submitted to haematopoietic stem cell transplantation
Segundas neoplasias en pacientes adultos receptores de un trasplante de progenitores hematopoyéticos
Anna Torrent
Corresponding author

Corresponding author.
, Christelle Ferrá, Mireia Morgades, María-José Jiménez, Juan-Manuel Sancho, Susana Vives, Montserrat Batlle, Miriam Moreno, Blanca Xicoy, Albert Oriol, Gladys Ibarra, Josep-Maria Ribera
Servicio de Hematología Clínica, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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Figures (1)
Tables (3)
Table 1. Clinical characteristics and variables related to the transplantation of hematopoietic stem cells in the global series and in patients with a second neoplasm or without it.
Table 2. Characteristics of the second neoplasms in the global series and according to the type of hematopoietic stem cell transplant.
Table 3. Analysis of risk factors for the development of the second neoplasm.
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Background and objective

Patients submitted to haematopoietic stem cell transplantation (HSCT) are at increased risk of late complications, such as second neoplasm (SN). The incidence and risk factors of SN in patients receiving HSCT at a single centre were analyzed.

Patients and methods

The follow-up of adult patients who received a first HSCT (autologous [auto-HSCT] or allogeneic [allo-HSCT]) between January 2000 and December 2015 was reviewed. We collected their demographic characteristics, the primary disease and type of HSCT, and analyzed the cumulative incidence of SN and their risk factors.


Of 699 transplanted patients (auto-HSCT, n=451; allo-HSCT, n=248), 42 (6%) developed SN (17 haematological and 25 solid), 31 post-auto-HSCT and 11 post-allo-HSCT. Haematologic SN were more frequent after auto-HSCT than after allo-HSCT. The median time between HSCT and SN was 4.09 years [range 0.07–13.15], with no differences between auto-HSCT and allo-HSCT. The cumulative incidence of SN was 5% (95% CI 3–6) at 5 years, 7% (95% CI 5–10) at 10 years and 11% (95% CI 8–15) at 15 years, without differences according to the type of HSCT. Only the age over 40 years correlated with an increased risk of SN.


In this series, the incidence of post-HSCT SN was similar to that previously described. Patients submitted to an auto-HSCT showed a higher frequency of haematologic SN. A higher incidence of SN was detected in patients older than 40 at the time of HSCT.

Haematopoietic stem cell transplantation
Second neoplasms
Solid tumours
Haematologic neoplasms
Fundamento y objetivo

Los receptores de un trasplante de progenitores hematopoyéticos (TPH) tienen un mayor riesgo de complicaciones tardías, como las segundas neoplasias (SN). Se analizó la incidencia de SN en pacientes receptores de un TPH en un centro.

Pacientes y métodos

Estudio retrospectivo de pacientes adultos receptores de un primer TPH (autogénico [auto-TPH] o alogénico [alo-TPH]) entre enero de 2000 y diciembre de 2015. Se recogieron sus características demográficas, la enfermedad de base y el tipo de TPH, y se analizó la incidencia acumulada de SN y sus factores de riesgo.


De 699 pacientes receptores de un auto-TPH (n=451) o alo-TPH (n=248), 42 (6%) desarrollaron una SN (17 hematológicas y 25 sólidas), 31 postauto-TPH y 11 postalo-TPH. Se observó un mayor número de SN hematológicas tras auto-TPH que tras alo-TPH. La mediana de tiempo entre el TPH y la SN fue de 4,09 años [extremos 0,07-13,15], sin diferencias entre auto-TPH y alo-TPH. La incidencia acumulada de SN post-TPH fue de 5% (IC 95% 3-6) a 5 años, 7% (IC 95% 5-10) a 10 años y 11% (IC 95% 8-15) a 15 años, sin diferencias en función del tipo de TPH. Solo la edad superior a los 40 años se correlacionó con un mayor riesgo de SN.


En esta serie, la incidencia de SN post-TPH fue similar a la descrita. Los receptores de un auto-TPH presentaron mayor frecuencia de SN hematológicas. Se detectó una mayor incidencia de SN en pacientes de más de 40 años en el momento del TPH.

Palabras clave:
Trasplante de progenitores hematopoyéticos
Segundas neoplasias
Tumores sólidos
Neoplasias hematológicas


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