Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Risk factors of death from vascular events among cancer survivors: A SEER databa...
Journal Information
Vol. 156. Issue 2.
Pages 49-54 (January 2021)
Download PDF
More article options
Vol. 156. Issue 2.
Pages 49-54 (January 2021)
Original article
DOI: 10.1016/j.medcle.2020.02.010
Risk factors of death from vascular events among cancer survivors: A SEER database analysis
Factores de riesgo de muerte por episodios vasculares entre los supervivientes de cáncer: análisis de la base de datos SEER
Jian Wang, Xin Yan, Wei Feng, Wenhua Shi, Qingting Wang, Qianqian Zhang, Limin Chai, Pengtao Liu, Yuqian Chen, Cong Li, Manxiang Li
Corresponding author

Corresponding author.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, PR China
Article information
Full Text
Download PDF
Figures (1)
Tables (2)
Table 1. Basic characteristics of study population.
Table 2. Multivariate hazard regression analysis of risk factors for vascular events caused death.
Show moreShow less
Additional material (2)

Cancer is the most important leading cause of death in the world and vascular events are the second-leading cause of death in cancer patients after cancer itself. Understanding related risk factors associated with vascular events may help clinicians develop appropriate treatment strategies. However, few large-scale population-based studies have investigated the risk factors for vascular events among cancer patients.

Materials and methods

The study involved a retrospective evaluation of medical records from the SEER database. Ten most common cancers in the past 20 years were extracted from the database. Cox proportional hazards model was used to analyze risk factors affecting vascular events that caused death among cancer patients.


This study revealed that cancer patients had a serious risk of vascular events caused death, the 1-year, 3-year, 5-year and the overall rates of mortality from vascular events were 6.0%, 10.8%, 17.9% and 25.8%, respectively. The results showed that male, black race, elderly, AJCC stage II, stage III and stage IV, with no multiple primary cancers and no surgical treatment were associated with a significantly increased risk of vascular events caused death.


We hope this research can alert clinicians and help them select high-risk cancer patients who may die from vascular events. And for those patients, we recommend that clinicians regularly monitor the patient's coagulation function and perform individualized thromboprophylaxis promptly to reduce the risk of death from vascular events.

Risk factor
SEER database

El cáncer es la causa más importante de muerte a nivel mundial, y los episodios vasculares son la segunda causa más importante de muerte en los pacientes de cáncer, tras la enfermedad en sí misma. Comprender los factores de riesgo relacionados con los episodios vasculares puede ayudar a los facultativos a desarrollar estrategias terapéuticas adecuadas. Sin embargo, son pocos los estudios a gran escala basados en población que investigan los factores de riesgo de los episodios vasculares entre los pacientes de cáncer.

Materiales y métodos

El estudio incluyó la evaluación retrospectiva de las historias médicas de la base de datos SEER, de donde se extrajeron los 10 tipos de cáncer más comunes en los últimos 20 años. Se utilizó el modelo de regresión de Cox para analizar los factores de riesgo que afectan a los episodios vasculares que causaron la muerte entre los pacientes de cáncer.


Este estudio reveló que los pacientes de cáncer tenían un riesgo grave de muerte causada por episodios vasculares. Las tasas de mortalidad causada por episodios vasculares a 1, 3, 5 años y global, fueron del 6, 10,8, 17,9 y 25,8%, respectivamente. Los resultados reflejaron que los varones, de raza negra, mayores, con AJCC estadios II, III y IV, sin cánceres primarios múltiples y sin tratamiento quirúrgico estaban relacionados con el incremento del riesgo significativo de muertes causadas por episodios vasculares.


Esperamos que esta investigación pueda alertar a los clínicos, y ayudarles a seleccionar a los pacientes de cáncer con alto riesgo de muerte causada por episodios vasculares. Y recomendamos también que los facultativos supervisen regularmente la función de coagulación de dichos pacientes, realizando tromboprofilaxis individualizada para reducir el riesgo de muertes causadas por episodios vasculares.

Palabras clave:
Factor de riesgo
Base de datos SEER


These are the options to access the full texts of the publication Medicina Clínica (English Edition)

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Medicina Clínica (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
Supplemental materials
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos