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Inicio Medicina Clínica (English Edition) Renal function and acute heart failure outcome
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Vol. 151. Issue 7.
Pages 281-290 (October 2018)
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Vol. 151. Issue 7.
Pages 281-290 (October 2018)
Renal function and acute heart failure outcome
Función renal y pronóstico de los episodios de insuficiencia cardiaca aguda
Lluís Llaugera,
Corresponding author

Corresponding author.
, Javier Jacobc, Òscar Mirób
a Servicio de Urgencias, Hospital Universitari de Vic, Vic, Barcelona, Spain
b Servicio de Urgencias, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
c Servicio de Urgencias, Hospital Clínic de Barcelona, Barcelona, Spain
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Figures (1)
Tables (5)
Table 1. Studies that analyze the prognostic significance of serum creatinine in acute heart failure.
Table 2. Studies analysing the prognostic significance of blood urea nitrogen (BUN) and the BUN/creatinine ratio.
Table 3. Established chronic kidney disease and formula for calculating the estimated glomerular filtration rate (eGFR).
Table 4. Criteria for acute kidney injury.
Table 5. New biomarkers.
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The interaction between acute heart failure (AHF) and renal dysfunction is complex. Several studies have evaluated the prognostic value of this syndrome. The aim of this systematic review, which includes non-selected samples, was to investigate the impact of different renal function variables on the AHF prognosis. The categories included in the studies reviewed included: creatinine, blood urea nitrogen (BUN), the BUN/creatinine quotient, chronic kidney disease, the formula to estimate the glomerular filtration rate, criteria of acute renal injury and new biomarkers of renal damage such as neutrophil gelatinase-associated lipocalin (NGAL and cystatin c). The basal alterations of the renal function, as well as the acute alterations, transient or not, are related to a worse prognosis in AHF, it is therefore necessary to always have baseline, acute and evolutive renal function parameters.

Renal function
Acute heart failure
Systematic review

La insuficiencia cardiaca aguda (ICA) y la disfunción renal son 2entidades para cuya compleja interacción se ha explorado su valor pronóstico. El objetivo de esta revisión sistemática de trabajos, que parte de muestras no seleccionadas, fue investigar el impacto que tienen diversas variables de función renal sobre el pronóstico de la ICA. La creatinina, el nitrógeno ureico (BUN), el cociente BUN/creatinina, la enfermedad renal crónica, la fórmula para estimar la tasa de filtrado glomerular, los criterios de lesión renal aguda y los nuevos biomarcadores de daño renal (NGAL y la cistatina C) son las categorías en que se han incluido los trabajos revisados. Las alteraciones basales, así como las alteraciones agudas, transitorias o no, de la función renal se relacionan con un peor pronóstico en la ICA. Es, por lo tanto, necesario tener siempre parámetros de función renal basales, del episodio agudo y evolutivos.

Palabras clave:
Función renal
Insuficiencia cardiaca aguda
Revisión sistemática


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