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Inicio Medicina Clínica (English Edition) Prospective follow-up of adult long-term survivors of allogeneic haematopoietic ...
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Vol. 157. Issue 6.
Pages 281-284 (September 2021)
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Vol. 157. Issue 6.
Pages 281-284 (September 2021)
Brief report
DOI: 10.1016/j.medcle.2020.07.030
Prospective follow-up of adult long-term survivors of allogeneic haematopoietic stem cell transplantation
Estudio prospectivo del seguimiento de pacientes largos supervivientes a un trasplante alogénico de progenitores hematopoyéticos
Anna Torrenta,
Corresponding author

Corresponding author.
, Christelle Ferráa,b, Montserrat Batllea, Fátima Hidalgoa, Maria-José Jiménez-Lorenzoa, Josep-Maria Riberaa
a Servicio de Hematología Clínica, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucemia Josep Carreras, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
b Universitat de Vic, Universitat Central de Catalunya, Vic, Barcelona, Spain
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Tables (2)
Table 1. Main characteristics of the long-term survivors of allogeneic HSCT (No. = 107) detected in the HSCT database.
Table 2. Diagnostic tests, actions taken, and treatments administered during the first visit in long-term survivors of HSCT.
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Background and objective

Patients who survive beyond two years after haematopoietic stem cell transplantation (HSCT) have an increased risk of long-term complications, which impact on their survival and quality of life. The aim of this study was to design and apply a long-term follow-up protocol to detect unmet needs and treat these complications early.

Patients and method

A prospective study to detect and treat complications and long-term problems within an interdisciplinary functional unit was applied to survivors beyond 2 years of allogeneic HSCT (alloHSCT).


Thirty-six (36%) of the 99 patients included, required intervention in a cardiovascular risk factor by health education or antihypertensive and lipid-lowering drugs. Nine of 36 (25%) patients required calcium and vitamin D intake. Low inclusion of women in gynaecological neoplasm detection protocols was detected, as well as a low adherence to dental follow-up after alloHSCT.


The follow-up of long-term survivors after alloHSCT in a multidisciplinary unit allowed unmet needs to be detected and controlled, especially in cardiovascular risk, bone metabolism, cancer prevention, and dental control.

Haematopoietic stem cell transplantation
Long-term survivors
Fundamento y objetivo

Los pacientes que sobreviven más allá de dos años del trasplante de progenitores hematopoyéticos (TPH), tienen un riesgo aumentado de complicaciones a largo plazo, que tienen impacto en su supervivencia y calidad de vida. El objetivo de este estudio fue diseñar y aplicar un protocolo de seguimiento a largo plazo para detectar necesidades no cubiertas y tratar precozmente dichas complicaciones.

Pacientes y método

A los supervivientes más allá de 2 años del TPH alogénico (aloTPH) se aplicó una sistemática de estudio para detectar y tratar complicaciones y problemas a largo plazo dentro de una unidad funcional interdisciplinar.


Treinta y seis (36%) de los 99 pacientes incluidos, requirieron de intervención en alguno de los factores de riesgo cardiovascular mediante educación sanitaria o administración de fármacos antihipertensivos e hipolipemiantes. Nueve (25%) de 36 pacientes requirieron aporte de calcio y vitamina D. Se detectó una baja reincorporación de las mujeres a los protocolos de detección de neoplasias ginecológicas, y una baja adherencia al seguimiento odontológico tras el aloTPH.


El seguimiento de los largos supervivientes a un aloTPH en una unidad multidisciplinaria permitió detectar necesidades no cubiertas, que afectaron especialmente al riego cardiovascular, metabolismo óseo, prevención del cáncer y control odontológico.

Palabras clave:
Trasplante de progenitores hematopoyéticos
Largos supervivientes


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