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Inicio Medicina Clínica (English Edition) Patient characterization and adverse health care-related events in SARS-CoV-2 in...
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Vol. 156. Issue 6.
Pages 277-280 (March 2021)
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Vol. 156. Issue 6.
Pages 277-280 (March 2021)
Brief report
DOI: 10.1016/j.medcle.2020.11.009
Patient characterization and adverse health care-related events in SARS-CoV-2 infected patients who died in a tertiary hospital
Caracterización y eventos adversos relacionados con la asistencia sanitaria en pacientes infectados por el SARS-CoV-2 fallecidos en un hospital de tercer nivel
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Guillermo Menaa,b,
Corresponding author
, Eva Montanéb,c, Mónica Rodríguezb,d, Patricia Beroize, Juan J. López-Núñezf, Mónica Ballesterg
a Servicio de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
b Universitat Autònoma de Barcelona, Bellaterra, Badalona, Spain
c Servicio de Farmacología Clínica, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
d Servicio de Anestesiología y Reanimación, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
e Servicio de Geriatría, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
f Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
g Dirección de Calidad, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
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Tables (2)
Table 1. Characteristics of patients infected with SARS-CoV-2, who died during hospitalisation during the study period (n = 164).
Table 2. Distribution of patients with adverse events and potentially related deaths associated with healthcare among SARS-CoV-2 infected patients who died during hospitalisation during the study period.
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Abstract
Objective

To characterize health care-related adverse events in patients with SARS-CoV-2 infection who died in a tertiary hospital.

Methods

This is a retrospective, observational study, that included patients who died at HUGTiP hospital between 16 March and 10 April 2020. Data was extracted from the electronic medical record.

Results

The median age of the 164 SARS-CoV-2 infected patients who died in the center in the study period was 77.5 years and >90% of patients had ≥1 comorbidity. Forty point two percent of patients had at least ≥1 health care-related adverse event. Twenty three point eight of patients had an adverse drug reaction, the leading cause of adverse events in patients who died. Of patients who died in intensive care units, the frequency of problems related to mechanical ventilation was 8.8%.

Conclusions

Although the case fatality rate associated with the adverse events detected was very low, close monitoring of potential health care-related adverse events, especially drug reactions, as the therapeutic management of the disease remains unclear.

Keywords:
COVID-19
SARS-CoV-2
Pandemic
Adverse events
Adverse drug reactions
Mortality
Resumen
Objetivo

Caracterizar los eventos adversos relacionados con la asistencia sanitaria en pacientes infectados por SARS-CoV-2 fallecidos en un hospital de tercer nivel.

Métodos

Estudio observacional retrospectivo en el que se incluyeron los pacientes fallecidos en el centro entre el 16 de marzo y el 10 de abril de 2020. La información fue extraída desde la historia clínica electrónica.

Resultados

La mediana de edad de los 164 pacientes analizados fue de 77,5 años. Más de 9 de cada 10 pacientes fallecidos presentaban al menos una comorbilidad. El 40,2% de los pacientes presentó al menos un evento adverso (EA) asociado a la atención sanitaria. Un 23,8% de los pacientes presentó alguna reacción adversa a medicamentos, constituyendo la primera causa de EA entre los pacientes fallecidos. Entre los pacientes que fallecieron en unidades de cuidados intensivos, los problemas relacionados con la ventilación mecánica han aparecido con una frecuencia del 8,8%.

Conclusiones

A pesar de que la letalidad asociada a los EA detectados fue muy reducida, es fundamental establecer una vigilancia estrecha de los posibles EA asociados a la asistencia sanitaria, especialmente los farmacológicos, dado que se trata de una enfermedad con un manejo terapéutico incierto.

Palabras clave:
COVID-19
SARS-CoV-2
Pandemia
Eventos adversos
RAM
Mortalidad

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