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Vol. 154. Issue 9.
Pages 351-357 (May 2020)
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Vol. 154. Issue 9.
Pages 351-357 (May 2020)
Review
New antibiotics for the treatment of infections by multidrug-resistant microorganisms
Nuevos antibióticos para el tratamiento de las infecciones por microorganismos multirresistentes
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Laura Escolà-Vergéa,b, Ibai Los-Arcosa,b,
Corresponding author
ibai.losarcos@gmail.com

Corresponding author.
, Benito Almirantea,b
a Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d’Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain
b Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain
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Table 1. Approved and potential indications of new antibiotics for the treatment of gram-positive and gram-negative bacteria infections.
Abstract

One of the current priorities of the World Health Organization is multidrug-resistant bacteria, because they are a global problem due to their rapid spread and the difficulty of their treatment. In addition, they are associated with high morbidity, mortality and high economic costs. There are multidrug-resistant bacteria, both Gram-positive and Gram-negative, including Pseudomonas aeruginosa and Acinetobacter baumannii resistant to carbapenems, enterobacteria producing carbapenemases, Staphylococcus aureus resistant to methicillin and/or with intermediate sensitivity to vancomycin, and Enterococcus faecium (and less frequently Enterococcus faecalis) resistant to vancomycin. This review will comment on the new antibiotics that have been incorporated into the therapeutic arsenal in recent years, as well as other promising antibiotics that are in their final stages of development.

Keywords:
Multidrug-resistant bacteria
Gram-positive bacteria
Gram-negative bacteria
Therapeutic
Antimicrobial agents
Resumen

Una de las prioridades actuales de la Organización Mundial de la Salud son las bacterias multirresistentes, dado que constituyen un problema en todo el mundo por su rápida diseminación, así como por la dificultad de su tratamiento. Además, se asocian a una alta morbilidad, mortalidad y a unos costes económicos elevados. Hay bacterias multirresistentes tanto grampositivas como gramnegativas, destacando entre ellas Pseudomonas aeruginosa y Acinetobacter baumannii resistentes a las carbapenemas, enterobacterias productoras de carbapenemasas, Staphylococcus aureus resistente a la meticilina y/o con sensibilidad intermedia a la vancomicina y Enterococcus faecium (y menos frecuentemente Enterococcus faecalis) resistente a la vancomicina. En esta revisión se comentarán los nuevos antibióticos que se han incorporado en los últimos años al arsenal terapéutico, así como otros antibióticos prometedores que se encuentran en sus últimas fases de desarrollo.

Palabras clave:
Bacterias multirresistentes
Grampositivos
Gramnegativos
Terapéutica
Antimicrobianos

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