Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Microvascular thrombosis and clinical implications
Journal Information
Vol. 156. Issue 12.
Pages 609-614 (June 2021)
Share
Share
Download PDF
More article options
ePub
Visits
4
Vol. 156. Issue 12.
Pages 609-614 (June 2021)
Review
DOI: 10.1016/j.medcle.2020.12.025
Microvascular thrombosis and clinical implications
Trombosis microvascular y sus implicaciones clínicas
Visits
...
José A. Páramo
Servicio de Hematología, Clínica Universidad de Navarra, IdiSNA, CIBERCV, Pamplona, Navarra, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (4)
Table 1. Vascular endothelium thromboregulatory mechanisms.
Table 2. Diseases associated with microvascular thrombosis.
Table 3. PLASMIC index for the diagnosis of thrombocytopenic thrombotic purpura.
Table 4. HIT Clinical Probability Index (4 Ts).
Show moreShow less
Abstract

Thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. Further, microvascular thrombosis has recently been demonstrated in patients with COVID-19, and has been proposed to mediate the pathogenesis of organ injury in the lung and other organs. In many of these conditions, microvascular thrombosis is accompanied by inflammation, an association referred to as thromboinflammation or immunothrombosis. A greater understanding of the links between inflammation and thrombosis in the microcirculation will provide new therapeutic options for human diseases accompanied by microvascular thrombosis.

Keywords:
Microvascular thrombosis
Thrombotic microangiopathies
Disseminated intravascular coagulation
Immunothrombosis
COVID-19
Plasma exchange
Resumen

La trombosis en la microcirculación está presente en numerosas situaciones clínicas, como coagulación intravascular diseminada, microangiopatía trombótica o anemia falciforme, entre otras. Asimismo, se ha demostrado trombosis microvascular en pacientes con COVID-19 como un mecanismo patogénico implicado en la lesión tisular pulmonar y de otros órganos. La trombosis microvascular se acompaña frecuentemente de inflamación, una asociación conocida como tromboinflamación o inmunotrombosis. El conocimiento de las interacciones entre inflamación y trombosis abre nuevas perspectivas en el tratamiento de enfermedades que cursan con trombosis microvascular.

Palabras clave:
Trombosis microvascular
Microangiopatías trombóticas
Coagulación intravascular diseminada
Inmunotrombosis
COVID-19
Recambio plasmático

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos