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Inicio Medicina Clínica (English Edition) Interleukin 6 and depression in patients affected by Covid-19
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Vol. 156. Issue 7.
Pages 332-335 (April 2021)
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Vol. 156. Issue 7.
Pages 332-335 (April 2021)
Brief report
DOI: 10.1016/j.medcle.2020.11.013
Interleukin 6 and depression in patients affected by Covid-19
Relación entre los niveles de interleucina 6 y depresión en pacientes afectados por Covid-19
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Antonio Serrano Garcíaa,
Corresponding author
, Judith Montánchez Mateob, Clara Margarita Franch Patoa, Rocío Gómez Martíneza, Paula García Vázqueza, Isabel González Rodrígueza
a Servicio de Psiquiatría, Complejo Asistencial Universitario de León, León, Spain
b Servicio de Inmunología Clínica, Complejo Asistencial Universitario de León, León, Spain
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Table 1. Correlation of the questions of the Yesavage scale with psychopathology and associated neurotransmitters.
Table 2. Study variables score.
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Abstract
Introduction

Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms.

Objectives

To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. Characterize the depressive symptoms present.

Methods

Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale was used, associating each item with a neurotransmitter.

Results

27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho = 0.204; 95% CI −0.192 to 0.543); with IL-1β levels (rho = −0.126; 95% CI −0.490 to 0.276); nor of TNF-α (rho = −0.033; 95% CI −0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of Noradrenaline and Serotonin.

Conclusions

We found no correlation between the levels of IL-6, IL-1β, and TNF-α with the GDS score. Depressive symptomatology is similar to vascular depressions.

Keywords:
Depression
IL-6
Covid-19
Vascular
IL-1β
TNF-α
Resumen
Introducción

El incremento de citocinas centrales resultante de infecciones produce cambios neuronales. La Covid-19 permite estudiar los síntomas depresivos en un estrés sostenido y su relación con mecanismos moleculares.

Objetivos

Valorar la correlación entre niveles de IL-6, IL-1β y TNF-α y sintomatología depresiva. Caracterizar los cuadros depresivos presentes.

Métodos

Estudio observacional. Se incluyeron pacientes ingresados por Covid-19 mayores de 60 años con una determinación de interleucinas. Se utilizó la Escala de depresión geriátrica de Yesavage, asociándose cada ítem con un neurotransmisor.

Resultados

27 pacientes incluidos. No encontramos correlación entre los niveles de IL-6 y la puntuación de la escala GDS (rho = 0,204; IC95% −0.192 a 0.543); con los niveles de IL-1β (rho = −0,126; IC95% −0.490 a 0.276); ni de TNF-α (rho = −0,033; IC95% −0.416 a 0.360). 3 pacientes (11,1%) presentaron una puntuación compatible con cuadro depresivo. Se asoció a déficit de Noradrenalina y Serotonina.

Conclusiones

No hallamos correlación entre los niveles de IL-6, IL-1β y TNF-α con la puntuación en la GDS. La sintomatología depresiva presenta características similares a las depresiones vasculares.

Palabras clave:
Depresión
IL-6
Covid-19
Vascular
IL-1β
TNF-α

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