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Inicio Medicina Clínica (English Edition) Hepatitis C-related cirrhosis. Current status
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Vol. 148. Issue 2.
Pages 78-85 (January 2017)
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Vol. 148. Issue 2.
Pages 78-85 (January 2017)
Review
Hepatitis C-related cirrhosis. Current status
Cirrosis por hepatitis C. Estado actual
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...
Isabel Condea,b,
Corresponding author
conde_isa@gva.es

Corresponding author.
, Carmen Vinaixaa,c, Marina Berenguera,c,d
a Unidad de Hepatolog??a y Trasplante Hep??tico, Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, Spain
b Instituto de Investigaci??n Sanitaria del Hospital Universitario La Fe, Valencia, Spain
c Centro de Investigaci??n Biom??dica en Red de Enfermedades Hep??ticas y Digestivas (CIBERehd), Madrid, Spain
d Facultad de Medicina, Universidad de Valencia, Valencia, Spain
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Statistics
Figures (2)
Tables (3)
Table 1. Advantages and disadvantages of different methods to measure liver fibrosis.
Table 2. Direct-acting antivirals and its main characteristics.
Table 3. Major studies with direct acting antivirals in compensated cirrhotic, decompensated cirrhotic and liver transplant patients.
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Abstract

Chronic hepatitis C virus (HCV) infection affects around 150 million people. It is a leading cause of liver related morbidity and mortality through its predisposition to liver fibrosis, cirrhosis and end-stage liver complications. New treatments based on direct-acting antivirals have opened a new era in the management of HCV cirrhosis. They allow for HCV eradication without substantial side effects in almost all cirrhotic patients, reducing the risk of hepatocellular carcinoma, liver decompensation and mortality. This review provides an update on HCV cirrhosis. The paper focuses on the disease burden and major progresses in the diagnosis, follow-up and treatment of this patient subgroup.

Keywords:
Chronic hepatitis C
Liver cirrhosis
Direct-acting antivirals
Sustained virological response
Liver transplantation
Resumen

La infección crónica por el virus de la hepatitis C (VHC) afecta a cerca de 150 millones de personas. Es una de las principales causas de morbimortalidad asociadas al hígado por su relación con el desarrollo de fibrosis hepática, cirrosis y complicaciones por enfermedad hepática avanzada. Los nuevos tratamientos basados en antivirales de acción directa han supuesto una nueva era en el tratamiento de la cirrosis por virus C. Estos permiten la erradicación del virus, sin apenas efectos secundarios, en la gran mayoría de los pacientes cirróticos, consiguiendo así una reducción del riesgo de hepatocarcinoma, descompensación hepática y mortalidad. Este artículo, una actualización en la cirrosis por VHC, se centra en la relevancia de esta enfermedad y en los principales avances en el diagnóstico, el seguimiento y el tratamiento de este subgrupo de pacientes.

Palabras clave:
Hepatitis cr??nica C
Cirrosis hep??tica
Antivirales de acci??n directa
Respuesta viral sostenida
Trasplante hep??tico

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