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Inicio Medicina Clínica (English Edition) GESIDA/PETHEMA recommendations on the diagnosis and treatment of lymphomas in pa...
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Vol. 151. Issue 1.
Pages 39.e1-39.e17 (July 2018)
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Vol. 151. Issue 1.
Pages 39.e1-39.e17 (July 2018)
Consensus statement
DOI: 10.1016/j.medcle.2018.05.014
GESIDA/PETHEMA recommendations on the diagnosis and treatment of lymphomas in patients infected by the human immunodeficiency virus
Recomendaciones de GESIDA/PETHEMA sobre el diagnóstico y tratamiento de los linfomas en pacientes infectados por el virus de la inmunodeficiencia humana
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Pilar Mirallesa,
Corresponding author
pilarmirallesm@gmail.com

Corresponding author.
, José Tomás Navarrob, Juan Berenguera, José Gómez Codinac, Mi Kwona, David Serranoa, José Luis Díez-Martína, Salvador Villàb, Rafael Rubiod, Javier Menárgueza, José-María Ribera Santasusanab
a Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
b Institut Català d’Oncologia, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Josep Carreras, Universitat Autónoma de Barcelona, Badalona, Barcelona, Spain
c Hospital La Fe, Valencia, Spain
d Hospital 12 de Octubre, Madrid, Spain
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Tables (8)
Table 1. Clinical practice classification of the United States Public Health Service/Infectious Diseases Society of America (USPHS/IDSA).
Table 2. Diagnosis of extension of systemic NHL in HIV-infected patients.
Table 3. International Prognostic Index (IPI) for diffuse large B-cell lymphomas.
Table 4. Treatment with radiotherapy in patients with lymphoma associated with HIV infection.
Table 5. Overview of the treatment of non-Hodgkin's lymphomas associated with HIV infection.
Table 6. Hasenclever Prognostic Index for Advanced Hodgkin Disease.
Table 7. Practical recommendations for the treatment of Hodgkin's lymphoma in HIV-infected population.
Table 8. Autologous transplants of hematopoietic stem cell in patients with lymphomas and HIV infection.
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Abstract

The incidence of non-Hodgkin's lymphoma and Hodgkin's lymphoma is higher in patients with HIV infection than in the general population. Following the introduction of combination antiretroviral therapy (cART), the prognostic significance of HIV-related variables has decreased, and lymphoma-related factors have become more pronounced. Currently, treatments for lymphomas in HIV-infected patients do not differ from those used in the general population. However, differentiating characteristics of seropositive patients, such as the need for cART and specific prophylaxis and treatment of certain opportunistic infections, should be considered. This document updates recommendations on the diagnosis and treatment of lymphomas in HIV infected patients published by GESIDA/PETHEMA in 2008.

Keywords:
Non-Hodgkin's lymphoma
Hodgkin's lymphoma
HIV
AIDS
Antiretroviral therapy
Abbreviations:
ABC
ABVD
Ara-C
AZT
BCNU
BEACOPP
CDC
CHOP
CMV
CODOX-M/IVAC
d4
dd
DH
DHAP
MCD
EPOCH
AD-EPOCH-R EPOCH-R
MRS
ESHAP
FDG18
FTC
G-CSF
GESID
Gy
HBs
HHV-8
Hyper-CVAD
ICE
IL-6
IMRT
INSTI
PI
IPI
IT
NRTI
NNRTI
LANA-1
BL
DLBCL
CSF
LDH
HL
LMP1
NHL
SOL
PCNSL
Lymphomatous LM
MTX
MTX-HD
PCR
PD-1/PDL-1
PET-CT
PETHEM
CT
R-CHOEPR-CHOP
R-CHOP
R-EPOCH
CR
RT
MRI
OS
KS
EFS
SNC
SPECT
Stanford V
TAF
cART
TDF
TH
HSCT
3TC
UGT1A1
EBV
HBV
HIV
Resumen

La incidencia de linfoma no hodgkiniano y linfoma de Hodgkin es mayor en pacientes con infección por el VIH que en la población general. Tras la introducción del tratamiento antirretroviral de combinación (TARc) ha disminuido la importancia pronóstica de variables relacionadas con el VIH, adquiriendo mayor peso factores relacionados con el linfoma. Actualmente, los tratamientos de los linfomas en pacientes infectados por VIH no difieren de los empleados en la población general. Pero existen algunos aspectos diferenciales de los pacientes con VIH como la necesidad de TARc, de profilaxis y de tratamientos de algunas infecciones oportunistas. En este documento se actualizan las recomendaciones sobre el diagnóstico y el tratamiento de los linfomas en pacientes infectados por VIH publicadas por GESIDA/PETHEMA en 2008.

Palabras clave:
Linfoma no hodgkiniano
Linfoma de Hodgkin
VIH
Sida
Tratamiento antirretroviral

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