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Inicio Medicina Clínica (English Edition) Gastrointestinal stromal tumour and second tumours: A literature review
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Vol. 149. Issue 8.
Pages 345-350 (October 2017)
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Vol. 149. Issue 8.
Pages 345-350 (October 2017)
Review
Gastrointestinal stromal tumour and second tumours: A literature review
El tumor del estroma gastrointestinal y la aparición de segundos tumores: revisión de la bibliografía
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Rafael Núñez-Martín
Corresponding author
rnmartin18@gmail.com

Corresponding author.
, Ricardo Cubedo Cervera, Mariano Provencio Pulla
Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
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Table 1. Published studies with more than 100 patients.
Abstract

There are several tumours associated with gastrointestinal stromal tumour (GIST), most of them without an apparent family relationship; only 5% of them occur within the context of a family syndrome. In this article the corresponding literature about the former has been reviewed. A search in Pubmed was carried out, the methodology of which is described in detail in the body of the article.

A total of 88 articles have been chosen for the review, next to the application of limits as well as a manual review. GIST patients have a twofold risk of developing a second tumour than the general population (4–33% of them develop a second neoplasm, either synchronic or metachronic). Most incident tumours associated with GIST are gastrointestinal and genitourinary tumours. In addition, patients with second tumours have a worse survival rate than those without second tumours.

Keywords:
Gastrointestinal stromal tumour
Second tumours
Metachronous second primary
Synchronous neoplasm
Resumen

Existen una serie de tumores asociados al gastrointestinal stromal tumour (GIST, «tumor del estroma gastrointestinal»), la mayoría de los cuales ocurren sin una aparente relación familiar; solo un 5% suceden en el contexto de síndromes familiares. En este artículo se ha revisado la literatura médica existente sobre los primeros. Se ha elaborado una búsqueda en Pubmed cuya metodología se concreta en el cuerpo del artículo.

Han sido seleccionados para la revisión un total de 88 artículos tras la aplicación de límites y revisión manual. Los pacientes con GIST tienen un riesgo aproximadamente 2 veces mayor que la población general de desarrollar otro tumor (4–33% de ellos desarrollan una segunda neoplasia, ya sea sincrónica o metacrónica). Los tumores más frecuentemente asociados son los de origen gastrointestinal y genitourinario. Además, los pacientes con segundos tumores tienen una supervivencia peor que aquellos que padecen únicamente un GIST.

Palabras clave:
Tumor del estroma gastrointestinal
Segundos tumores
Segundo primario metacrónico
Neoplasia sincrónica

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