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Inicio Medicina Clínica (English Edition) Gastric MALT lymphoma and Helicobacter pylori
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Vol. 152. Issue 2.
Pages 65-71 (January 2019)
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Vol. 152. Issue 2.
Pages 65-71 (January 2019)
Review
Gastric MALT lymphoma and Helicobacter pylori
Linfoma MALT gástrico y Helicobacter pylori
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...
Antonio Salara,b
a Servicio de Hematología, Hospital del Mar, Barcelona, Spain
b Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
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Tables (5)
Table 1. Diagnostic tests for Helicobacter pylori.
Table 2. Treatment regimen for Helicobacter pylori.
Table 3. Histological scale for the diagnosis of gastric MALT lymphoma.
Table 4. Gastric lymphoma staging systems.
Table 5. Histological scale used to assess the response to treatment.
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Abstract

Marginal zone lymphomas of the MALT type are a type of B-cell neoplasms that involve extranodal tissues and have an indolent clinical behavior. The stomach is the most common site and most patients are infected by Helicobacter pylori. An increase in the resistance of this bacterium to several antibiotics has been observed in the last years and this fact has determined the review of treatment guidelines. In areas with resistance to clarithromycin greater than 15%, classical triple therapy should be abandoned and quadruple regimens with or without bismuth are currently recommended. Thus, these new guidelines for eradication treatment should be applied to patients with gastric MALT lymphoma associated with H. pylori infection.

Keywords:
MALT lymphoma
Gastric lymphoma
Helicobacter pylori
Eradication treatment
Resumen

Los linfomas de la zona marginal de tipo MALT son un tipo de neoplasias de células B que afectan tejidos extraganglionares y tienen un curso clínico indolente. El estómago es la localización más frecuente y la mayor parte de los pacientes están infectados por Helicobacter pylori. En los últimos años se ha observado un aumento de la resistencia de esta bacteria a varios antibióticos y este hecho ha motivado la revisión de las pautas de tratamiento. Actualmente se propone que en zonas geográficas con resistencias a claritromicina superiores al 15% se abandone la triple terapia clásica y se utilicen pautas cuádruples con o sin bismuto. Así, estas nuevas recomendaciones sobre el tratamiento erradicador se deben aplicar a los pacientes con linfoma MALT gástrico asociado a infección por H. pylori.

Palabras clave:
Linfoma MALT
Linfoma gástrico
Helicobacter pylori
Tratamiento erradicador

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