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Inicio Medicina Clínica (English Edition) Fracture risk assessment in the general population in Spain by FRAX® algorithm....
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Vol. 154. Issue 5.
Pages 163-170 (March 2020)
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Vol. 154. Issue 5.
Pages 163-170 (March 2020)
Original article
Fracture risk assessment in the general population in Spain by FRAX® algorithm. EPISER2016 study
Valoración del riesgo de fractura en población general en España mediante el algoritmo FRAX®: Estudio EPISER2016
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Carmen Gómez-Vaqueroa,
Corresponding author
, Dolores Fábregas-Canalesb, Daniel Seoane-Matoc, Carlos Sánchez-Piedrac, Federico Díaz-Gonzálezd,e, Sagrario Bustabad-Reyesd, on behalf of the EPISER2016 Project Working Group
a Servicio de Reumatología, IDIBELL-Hospital Universitari de Bellvitge, L’Hospitalet, Barcelona, Spain
b Servicio de Reumatología, Hospital de Barbastro, Barbastro, Huesca, Spain
c Unidad de Investigación de la Sociedad Española de Reumatología, Madrid, Spain
d Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
e Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain
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Figures (2)
Tables (5)
Table 1. Baseline characteristics of the sample and values in the general adult population in Spain.
Table 2. Frequency of fracture risk factors included in the FRAX® tool.
Table 3. Major and hip fracture risk calculated by FRAX® in the population, by sex and age (median and interquartile range).
Table 4. Prevalence of high fracture risk according to the FRAX tool® for different thresholds, by sex and age.
Table 5. Comparison of EPISER2016 with other similar studies regarding the prevalence of high fracture risk in the study population.
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Abstract
Objective

To analyse the risk of fracture calculated by FRAX and the frequency of high risk of fracture in the general population in Spain.

Methods

EPISER2016 is a multicentre cross-sectional population-based study of the prevalence of rheumatic diseases in the adult population in Spain. 3154 subjects aged ≥40 years 1184 men and 1970 women were selected by stratified random sampling. The questions related to fracture risk factors were asked by telephone survey. The risk of major osteoporotic fracture MOFR and hip fracture HFR were calculated with the Spanish version of the FRAX tool, without the inclusion of bone mineral density. To define high fracture risk, the MOFR20%, MOFR10%, MOFR7.5% and HFR3% thresholds were used.

Results

The median (interquartile range) of the MOFR was 2.61% (1.55–6.34%) in women and 1.67% (1.15–2.87%) in men, whereas that of the HFR was 0.39% (0.14–1.86%) and 0.18% (0.07–0.77%). 3.83% of women and no men had a MOFR20%; 15.71% and 1.14% had a MOFR10%; 20.62% and 2.21%, a MOFR7.5%; and 19.27% and 8.05%, an HFR3%. In women aged 65 and over, the HFR was high in 58.09%.

Conclusions

EPISER2016 enabled us to establish the risk of fracture calculated by FRAX and the prevalence of high risk of fracture in the general population according to the different thresholds used in Spain.

Keywords:
Risk factor
Risk of fracture
FRAX®
General population
Resumen
Objetivos

Analizar el riesgo de fractura calculado por FRAX y la frecuencia de alto riesgo de fractura en la población general en España.

Métodos

EPISER2016 es un estudio transversal multicéntrico de base poblacional de la prevalencia de las enfermedades reumáticas en población adulta en España. 3.154 sujetos de edad igual o superior a 40 años (1.184 hombres y 1.970 mujeres) se seleccionaron mediante muestreo aleatorio estratificado. Las preguntas relacionadas con los factores de riesgo de fractura se realizaron mediante encuesta telefónica. El riesgo de fractura principal (RFP) y de cadera (RFC) se calcularon con la versión española de la herramienta FRAX, sin la inclusión de la densidad mineral ósea. Para definir alto riesgo de fractura, se utilizaron los umbrales RFP20%, RFP10%, RFP7,5% y RFC3%.

Resultados

La mediana (rango intercuartílico) del RFP fue 2,61% (1,55–6,34%) en mujeres y 1,67% (1,15–2,87%) en hombres; la del RFC fue 0,39% (0,14–1,86%) y 0,18% (0,07–0,77%). El 3,83% de las mujeres y ningún hombre tenían un RFP20%; el 15,71% y el 1,14% tenían un RFP10%; el 20,62% y el 2,21%, un RFP7.5%; y el 19,27% y el 8,05%, un RFC3%. En las mujeres de 65 años o más, el RFC fue alto en el 58,09%.

Conclusiones

EPISER2016 nos ha permitido conocer el riesgo de fractura calculado por FRAX y la prevalencia de alto riesgo de fractura en la población general según los diversos umbrales utilizados en España.

Palabras clave:
Factor de Riesgo
Riesgo de fractura
FRAX®
Población general

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