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Inicio Medicina Clínica (English Edition) Follicular lymphoma: An update on diagnosis, prognosis, and management
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Vol. 157. Issue 9.
Pages 440-448 (November 2021)
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Vol. 157. Issue 9.
Pages 440-448 (November 2021)
Follicular lymphoma: An update on diagnosis, prognosis, and management
Actualización en el diagnóstico, pronóstico y tratamiento del linfoma folicular
Pablo Mozasa,
Corresponding author

Corresponding author.
, Marc Soriguéb, Armando López-Guillermoa,c
a Servicio de Hematología, Hospital Clínic, Barcelona, Spain
b Servicio de Hematología, ICO-IJC-Hospital Germans Trias i Pujol, Badalona, Spain
c Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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Tables (2)
Table 1. Recommended studies for the diagnosis, staging, prognosis and follow-up of FL.
Table 2. Most commonly used treatment regimens in FL.
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Follicular lymphoma, the most common indolent lymphoma, originates from germinal centre B-cells of the lymphoid follicle, and is characterized by t(14;18). Clinical manifestations include the presence of lymphadenopathy, sometimes accompanied by constitutional symptoms or cytopenia. Diagnosis is established through the identification of a B-cell proliferation of nodular pattern in the lymph node biopsy. Upon staging with PET-CT and bone marrow biopsy, a significant proportion of patients do not need immediate treatment. When therapy is indicated, commonly used regimens include anti-CD20 immunotherapy with or without chemotherapy. Although overall survival for most patients is prolonged, relapses are very frequent, and early relapse and transformation to an aggressive lymphoma portend a much worse prognosis. New therapies are under development, which will most likely change outcomes for FL patients in the near future.

Follicular lymphoma

El linfoma folicular, el linfoma indolente más frecuente, se origina en los linfocitos B del centro germinal del folículo linfoide y se caracteriza por la traslocación t(14;18). Clínicamente se manifiesta por la presencia de adenopatías, que pueden asociarse a síntomas constitucionales o citopenias. El diagnóstico se establece mediante la observación de una proliferación linfoide B de patrón nodular en la biopsia ganglionar, y la estadificación mediante un PET-TC y una biopsia de médula ósea. Una proporción significativa de pacientes no requiere tratamiento inmediato. Si lo requieren, suele estar basado en inmunoterapia anti-CD20 asociada o no a quimioterapia. A pesar de que la mayoría de pacientes presenta una supervivencia global prolongada, las recaídas son muy frecuentes, y la recaída precoz y la transformación a un linfoma agresivo confieren un mucho peor pronóstico. Se encuentran en desarrollo nuevos tratamientos que cambiarán las perspectivas de estos pacientes en un futuro próximo.

Palabras clave:
Linfoma folicular


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