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Inicio Medicina Clínica (English Edition) Epidermal growth factor, innovation and safety
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Vol. 145. Issue 7.
Pages 305-312 (October 2015)
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Vol. 145. Issue 7.
Pages 305-312 (October 2015)
Epidermal growth factor, innovation and safety
Factor de crecimiento epidérmico, innovación y seguridad
Jordi Esquirol Caussaa,b,
Corresponding author

Corresponding author.
, Elisabeth Herrero Vilaa,c
a Hospital Quirón Teknon, Barcelona, Spain
b Servei Universitari de Recerca en Fisioteràpia (SURF), Escoles Universitàries Gimbernat, Universitat Autònoma de Barcelona, Barcelona, Spain
c Servei de Medicina Preventiva, Àptima, Terrassa, Barcelona, Spain
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Figures (1)
Tables (2)
Table 1. Some of the significant studies published using recombinant human epidermal growth.
Table 2. Examples of compoundings containing recombinant human epidermal growth factor with possible indications and dosage.
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Bioidentical recombinant human epidermal growth factor (rhEGF) is available in concentrations and purity suitable for therapeutic use in long time stable formulations. Beneficial effects in several skin pathologies and lesions have been reported (traumatic and surgical wound healing, laser induced wounds, abnormal scars, keloids, radiation or chemotherapy induced dermatitis, post inflammatory hyperpigmentation or for skin aging damage repairing) and also may be considered for the treatment of several oropharingeal and high gastroesophageal tract mucosa diseases (mouth sores, pharyngeal fistulas, ulcers), and several corneal or conjunctive mucosa lesions.

rhEGF has not shown any important side or collateral effects in humans or in laboratory experimentation animals, showing optimal tolerability and safety with continuous use for months.

Compounding gives advantages of versatility, individualization, personalization, molecular stability, safety and effectiveness in ideal conditions, showing good tissue penetration, both on intact skin and skin lesions that expose the lower planes to the surface.

rhEGF compounds can be considered for prevention or as a treatment of diverse skin and mucosa diseases and conditions through compounding preparations.

Epidermal growth factor
Skin diseases
Skin aging
Skin care
Skin cream
Biological dressings
Pharmaceutical chemistry

El recombinant human epidermal growth factor (rhEGF, «factor de crecimiento epidérmico recombinante humano bioidéntico»), disponible en concentraciones y pureza aptas para uso terapéutico, dispone de formulaciones estables en el tiempo. Hay evidencias de efectos terapéuticos beneficiosos en diversas enfermedades y lesiones de la piel (heridas, cicatrices, queloides, dermatitis o alopecia por radiación o por quimioterápicos, hiperpigmentaciones posinflamación o daño causado por la edad), e igualmente puede ser considerado para el tratamiento de algunas afecciones de la mucosa orofaríngea y digestiva alta (aftosis, fístulas faríngeas, mucosas esofágica y gástrica) o para lesiones corneales y conjuntivales.

El rhEGF no muestra efectos secundarios o colaterales en humanos ni en animales de experimentación, evidenciando una óptima tolerabilidad y seguridad.

La formulación magistral otorga versatilidad, individualización, personalización, estabilidad molecular, seguridad y efectividad en condiciones idóneas, evidenciando una buena capacidad de penetración en el tejido, tanto en piel intacta como sobre lesiones cutáneas que exponen los planos inferiores a la superficie.

Se pueden considerar los compuestos con rhEGF para la prevención o tratamiento de diversas afecciones y enfermedades cutáneas o mucosas a través de preparados de formulación magistral.

Palabras clave:
Factor de crecimiento epidérmico
Enfermedades de la piel
Envejecimiento de la piel
Cuidados de la piel
Crema para la piel
Apósitos biológicos
Química farmacéutica


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