Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Epidermal growth factor, innovation and safety
Journal Information
Vol. 145. Issue 7.
Pages 305-312 (October 2015)
Share
Share
Download PDF
More article options
ePub
Visits
5
Vol. 145. Issue 7.
Pages 305-312 (October 2015)
Review
Epidermal growth factor, innovation and safety
Factor de crecimiento epidérmico, innovación y seguridad
Visits
...
Jordi Esquirol Caussaa,b,
Corresponding author
esquirol@dr.teknon.es

Corresponding author.
, Elisabeth Herrero Vilaa,c
a Hospital Quirón Teknon, Barcelona, Spain
b Servei Universitari de Recerca en Fisioteràpia (SURF), Escoles Universitàries Gimbernat, Universitat Autònoma de Barcelona, Barcelona, Spain
c Servei de Medicina Preventiva, Àptima, Terrassa, Barcelona, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (2)
Table 1. Some of the significant studies published using recombinant human epidermal growth.
Table 2. Examples of compoundings containing recombinant human epidermal growth factor with possible indications and dosage.
Show moreShow less
Abstract

Bioidentical recombinant human epidermal growth factor (rhEGF) is available in concentrations and purity suitable for therapeutic use in long time stable formulations. Beneficial effects in several skin pathologies and lesions have been reported (traumatic and surgical wound healing, laser induced wounds, abnormal scars, keloids, radiation or chemotherapy induced dermatitis, post inflammatory hyperpigmentation or for skin aging damage repairing) and also may be considered for the treatment of several oropharingeal and high gastroesophageal tract mucosa diseases (mouth sores, pharyngeal fistulas, ulcers), and several corneal or conjunctive mucosa lesions.

rhEGF has not shown any important side or collateral effects in humans or in laboratory experimentation animals, showing optimal tolerability and safety with continuous use for months.

Compounding gives advantages of versatility, individualization, personalization, molecular stability, safety and effectiveness in ideal conditions, showing good tissue penetration, both on intact skin and skin lesions that expose the lower planes to the surface.

rhEGF compounds can be considered for prevention or as a treatment of diverse skin and mucosa diseases and conditions through compounding preparations.

Keywords:
Epidermal growth factor
Skin diseases
Skin aging
Skin care
Skin cream
Biological dressings
Pharmaceutical chemistry
Resumen

El recombinant human epidermal growth factor (rhEGF, «factor de crecimiento epidérmico recombinante humano bioidéntico»), disponible en concentraciones y pureza aptas para uso terapéutico, dispone de formulaciones estables en el tiempo. Hay evidencias de efectos terapéuticos beneficiosos en diversas enfermedades y lesiones de la piel (heridas, cicatrices, queloides, dermatitis o alopecia por radiación o por quimioterápicos, hiperpigmentaciones posinflamación o daño causado por la edad), e igualmente puede ser considerado para el tratamiento de algunas afecciones de la mucosa orofaríngea y digestiva alta (aftosis, fístulas faríngeas, mucosas esofágica y gástrica) o para lesiones corneales y conjuntivales.

El rhEGF no muestra efectos secundarios o colaterales en humanos ni en animales de experimentación, evidenciando una óptima tolerabilidad y seguridad.

La formulación magistral otorga versatilidad, individualización, personalización, estabilidad molecular, seguridad y efectividad en condiciones idóneas, evidenciando una buena capacidad de penetración en el tejido, tanto en piel intacta como sobre lesiones cutáneas que exponen los planos inferiores a la superficie.

Se pueden considerar los compuestos con rhEGF para la prevención o tratamiento de diversas afecciones y enfermedades cutáneas o mucosas a través de preparados de formulación magistral.

Palabras clave:
Factor de crecimiento epidérmico
Enfermedades de la piel
Envejecimiento de la piel
Cuidados de la piel
Crema para la piel
Apósitos biológicos
Química farmacéutica

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos