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Inicio Medicina Clínica (English Edition) Chronic obstructive pulmonary disease mortality in Spain between 1999 and 2019
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Vol. 162. Issue 1.
Pages 9-14 (January 2024)
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Vol. 162. Issue 1.
Pages 9-14 (January 2024)
Original article
Chronic obstructive pulmonary disease mortality in Spain between 1999 and 2019
Mortalidad por enfermedad pulmonar obstructiva crónica en España entre 1999 y 2019
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Gema Ramírez-Rodrígueza,
Corresponding author
, Antonio Menéndez-Lobob, Alejandro Romero-Linaresa, Miriam Bernabéu-Fernández de Liencresb, Pedro Jose Romero-Palaciosb, Bernardino Alcázar-Navarretea,b,c,d, on behalf of “Spanish COPD mortality study group”
a Respiratory Department, Hospital Universitario Virgen de las Nieves, Granada, Spain
b Medicine Department, Universidad de Granada, Granada, Spain
c IBS Granada, Granada, Spain
d CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
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Abstract
Introduction

Mortality from COPD has decreased in Spain in recent years, but it is unknown whether this decline has been homogeneous among the different regions.

Methods

From the Statistical Portal of the Ministry of Health of Spain we obtained the age-adjusted mortality rates/100,000 inhabitants for men and women in Spain and the Autonomous Communities for the years 1999–2019, using the coding of the International Classification of Diseases (ICD 10, sections J40–J44). With the adjusted rates we performed a jointpoint regression analysis to estimate an annual percentage change (APC), as well as identify possible points of trend change. Statistical significance was considered for a value of p<0.05.

Results

During the study period, COPD mortality rates adjusted in Spain decreased from 28.77 deaths/100,000 inhabitants in 1999 to 12.14 deaths/100,000 inhabitants in 2019. We observed a linear decline in COPD mortality in men at national level of −3.67% per year (95% CI −4.1 to −3.4; p<0.001), with differences between the Autonomous Communities. Mortality in women also experienced a decrease in mortality in two phases, with a first period from 1999 to 2006 with a fall of −6.8% per year (95% CI −8.6 to −5.0; p<0.001) and a second period from 2006 to 2019 with a decrease in mortality of −2.1% (95% CI −2.8 to −1.3; p<0.001), with again differences between the Autonomous Communities.

Conclusion

Mortality rates from COPD have decreased heterogeneously among the different Autonomous Communities in both men and women.

Keywords:
COPD
Mortality rates
Trends
Jointpoint regression
Resumen
Introducción

La mortalidad por EPOC ha disminuido en España en los últimos años, pero se desconoce si esta caída ha sido homogénea entre las diferentes comunidades autónomas.

Metodología

consultando el Portal Estadístico del Ministerio de Sanidad de España obtuvimos las tasas ajustadas por edad/100.000 habitantes para hombres y mujeres de España y las CCAA para los años 1999 a 2019, utilizando la codificación de la Clasificación Internacional de Enfermedades (CIE 10, secciones J40 a J44). Con las tasas ajustadas realizamos un análisis de regresión de jointpoint con el objetivo de estimar un porcentaje anual de cambio (APC), así como identificar posibles puntos de cambio de tendencia. Se consideró la significación estadística para un valor de p<0.05.

Resultados

Durante el periodo de estudio, las tasas de mortalidad global ajustada por EPOC en España pasaron de 28.77 muertes/100.000 habitantes en 1999 a 12.14 muertes/100.000 habitantes en 2019. Observamos una caída de la mortalidad por EPOC en varones a nivel de España lineal del -3.67% anual (IC 95% -4.1 a -3.4; p<0.001), con diferencias entre las CCAA. La mortalidad en mujeres también experimentó una disminución de mortalidad en dos fases, con un primer periodo de 1999 a 2006 con caída del -6.8% anual (IC 95% -8.6 a -5.0; p<0.001) y un segundo periodo de 2006 a 2019 con un descenso de la mortalidad del -2.1% (IC 95% -2.8 a -1.3; p<0.001), encontrando diferencias entre las CCAA.

Conclusiones

Las tasas de mortalidad por EPOC han disminuido de forma heterogénea entre las diferentes CCAA.

Palabras clave:
EPOC
Tasas de mortalidad
Tendencias
Regresión de jointpoint

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