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Vol. 159. Issue 1.
Pages 1-5 (July 2022)
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Vol. 159. Issue 1.
Pages 1-5 (July 2022)
Original article
Association between sarcopenic obesity with insulin resistance and metabolic syndrome
Asociación entre obesidad sarcopénica con resistencia a la insulina y síndrome metabólico
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Elizabeth Pérez-Cruza,
Corresponding author
pece_liz@hotmail.com

Corresponding author.
, Daniela Castro-Martínezb, Otto Pavel González-Guzmanc
a Obesity Clinic, Hospital Juárez de México, México City, Mexico
b Internal Medicine, Hospital Juárez de México, México City, Mexico
c Emergencies, Hospital Juárez de México, México City, Mexico
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Abstract
Background

There is a debate as to whether sarcopenic obesity leads to an increased risk of metabolic syndrome in young adults.

Objective

To determine the association between sarcopenic obesity with metabolic syndrome (MS) and insulin resistance (IR).

Methods

A 5-year retrospective cross-sectional study. Subjects of the specialty consultation between 18 and 55 years old, with BMI35 with comorbidity or BMI40 with and without comorbidity were included. The association was calculated using an odds ratio with 95% confidence intervals.

Results

254 subjects were analyzed, 76.4% were women and average age was 38.36±8.78 years. The OR of IR in subjects with or without sarcopenic obesity was 2224 (95% CI, 1127 to 4389, p=0.02). The OR of MS in subjects with or without sarcopenia was 1.045 (95% CI, 0.624–1.748, p=0.868). A difference was found between the fat mass in the group with IR vs without IR of 60.58±14.4kg vs 53.98±12.2kg (p<0.001); likewise, between the BMI and muscle mass of 46.15±6.78 kg/m2 vs 43.51±6.11kg/m2 (p<0.05) and 30.05±7.48kg vs 27.86±5.91kg (<0.05) respectively.

Conclusion

The association between sarcopenic obesity with IR in young adults was significant, but not with MS. Our findings emphasize the need to become aware of the importance of maintaining lean mass in obese subjects.

Keywords:
Obesity
Sarcopenic obesity
Insulin resistance
Metabolic syndrome
Resumen
Introducción

Existe un debate en cuanto a si la obesidad sarcopénica conduce a mayor riesgo de síndrome metabólico en adultos jóvenes.

Objetivos

Determinar la asociación entre obesidad sarcopénica con el síndrome metabólico (SM) y resistencia la insulina (RI).

Métodos

Estudio transversal retrospectivo durante 5 años. Se incluyeron sujetos de la consulta de especialidad entre 18 y 55 años, con IMC35 con comorbilidad o IMC40 con y sin comorbilidad. La asociación se calculó mediante odds ratio (OR) con intervalos de confianza del 95%.

Resultados

254 sujetos fueron analizados, 76.4% fueron mujeres, la edad promedio fue de 38.36±8.78 años. El OR de RI en sujetos con o sin obesidad sarcopénica fue de 2.224 (IC del 95%, 1.127 a 4.389, p=0.02). El OR del SM en sujetos con o sin sarcopenia fue de 1.045 (IC del 95%, 0.624 a 1.748, p=0.868). Se encontró una diferencia entre la masa grasa en el grupo con RI vs sin RI de 60.58±14.4kg vs 53.98±12.2kg (p<0.001); igualmente entre el IMC y masa muscular de 46.15±6.78kg/m2 vs 43.51±6.11k /m2 (p<0.05) y 30.05±7.48kg vs 27.86±5.91kg (<0.05) respectivamente.

Conclusión

La asociación de obesidad sarcopénica con RI en adultos jóvenes resulto significativa, no así con el SM. Nuestros hallazgos enfatizan la necesidad de tomar conciencia sobre la importancia del mantenimiento de la masa magra en sujetos con obesidad.

Palabras clave:
Obesidad
Obesidad sarcopénica
Resistencia a la insulina
Síndrome metabólico

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