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Inicio Medicina Clínica (English Edition) Association between hemoglobin Groene Hart and hemoglobin J-Paris-I: First case ...
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Vol. 144. Issue 5.
Pages 212-215 (March 2015)
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Vol. 144. Issue 5.
Pages 212-215 (March 2015)
Clinical report
DOI: 10.1016/j.medcle.2015.05.032
Association between hemoglobin Groene Hart and hemoglobin J-Paris-I: First case in Spain
Asociación de la hemoglobina Groene Hart con la hemoglobina J-París-I: primer caso en España
Félix de la Fuente-Gonzalo
Corresponding author

Corresponding author.
, Paloma Ropero, Jorge Martínez-Nieto, Ana Villegas, Fernando A. González, Joaquín Díaz-Mediavilla
Servicio de Hematología, Hospital Clínico San Carlos, Madrid, Spain
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Tables (1)
Table 1. Hematological parameters and genotype of the study subjects.
Background and objective

Thalassemias are the most frequent monogenic disorder around the world. α-Thalassemias are due to a deficiency of synthesis in the alpha-globin chain of the hemoglobin (Hb). Hb Groene Hart is a hyperunstable variant. In this work, we have studied 24 cases affected by Hb Groene Hart, one of them associated with Hb J-Paris-I.

Patients and methods

Twenty-four patients from 17 unrelated families were included in this study. The characterisation was done by sequencing.


α1 gene sequencing showed the mutation CCT→TCT (Pro→Ser) at codon 119 (Hb Groene Hart) in all patients. In one case, there was an association with Hb J-Paris-I.


In the Hb Groene Hart, the residue 119 of alpha-globin chain is affected. This amino acid has a key role in preserving the stability of alpha-globin chain. It is also remarkable the presence of this variant in both the immigrant and native population. Thus, the identification of Hb Groene Hart carriers should be considered in the screening of α-thalassemia in Spain, as it is done in Northern Africa.

Non-deletional alpha-thalassemia
Hyperunstable hemoglobinopathies
Fundamento y objetivo

Las talasemias son las enfermedades monogénicas más frecuentes a nivel mundial. Representan un grave problema sanitario en las regiones de mayor incidencia. Las α-talasemias se deben a un déficit de síntesis de las cadenas α de la hemoglobina (Hb). La Hb Groene Hart es una variante hiperinestable. En este trabajo se presentan 24 casos pertenecientes a 17 familias afectadas por la Hb Groene Hart, uno de ellos asociado con Hb J-París-I.

Pacientes y método

Veinticuatro pacientes de 17 familias no relacionadas fueron incluidos en este estudio. La caracterización se realizó mediante secuenciación.


La secuenciación del gen α1 mostró la mutación CCT→TCT (Pro→Ser) en el codón 119 (Hb Groene Hart). En un paciente se asoció con la Hb J-París-I.


En la Hb Groene Hart se encuentra afectado un residuo clave para preservar la estabilidad de las cadenas α de globina. La presencia de esta variante es elevada en población española e inmigrante. La aparición de formas graves de la enfermedad podría ser evitada incorporando esta mutación al cribado de las mutaciones α-talasemia no deleción.

Palabras clave:
Alfatalasemia no deleción
Hemoglobinopatías hiperinestables


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