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Inicio Medicina Clínica (English Edition) Anticholinergic drugs and cognitive impairment in the elderly
Journal Information
Vol. 151. Issue 4.
Pages 141-144 (August 2018)
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Vol. 151. Issue 4.
Pages 141-144 (August 2018)
Brief report
Anticholinergic drugs and cognitive impairment in the elderly
Fármacos anticolinérgicos y deterioro cognitivo en el anciano
Núria López-Matons
Corresponding author

Corresponding author.
, Dolors Conill Badell, Gloria Obrero Cusidó, Domènec Gil Saladié, Jaume Padrós Selma, Adela Martin-López
Unitat de Valoració Geriàtrica Integral, GrupMutuam, Barcelona, Spain
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Figures (1)
Tables (2)
Table 1. Distribution of sociodemographic and covariable characteristics of the sample with two assessments and in patients exposed and not exposed to AD. Drug and score distribution between the two years.
Table 2. Mean difference in the scores of the assessment scales (2016 minus 2015) between exposed and unexposed patients.
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Describe the prevalence of the anticholinergic drugs (AD) used in patients who consult in regard to loss of memory. Assess the cognitive and functional repercussion of these drugs.

Patients and methods

Retrospective review of the clinic history of the patients who consulted the clinic in 2015 and 2016. We used the Anticholinergic Cognitive Burden Scale. We explored cognition with the Mini Mental State Examination (MMSE) and function with the Barthel Index and the Lawton and Brody Scale. We compared the difference of scale scores between the patients exposed and not exposed to AD.


Sample size of 610 patients (mean age=81.1years), 71% female. 37.2% of patients took AD. The mean (SD) difference between exposed and not exposed patients and the year-on-year worsening rate of the Barthel Index and the Lawton and Brody Scale and MMSE were −4 (4.5), −0.3 (0.4) and −1 (0.9), respectively.


One third of patients who consulted for cognitive loss are taking AD. Patients exposed to AD show a greater tendency to impairment.

Cholinergic antagonists

Describir la prevalencia de uso de fármacos anticolinérgicos (FA) en pacientes de edad avanzada que consultan por pérdida cognitiva. Valorar la repercusión cognitiva y funcional de estos fármacos.

Pacientes y métodos

Revisión retrospectiva de historias clínicas de pacientes visitados en 2015 y 2016. Se identificaron FA con la Anticholinergic Cognitive Burden Scale. La función cognitiva se exploró mediante el Mini Mental State Examination (MMSE) y la funcional con el índice de Barthel y el índice de Lawton y Brody. Se comparó la diferencia de las puntuaciones de las escalas en un año entre los pacientes expuestos a anticolinérgicos con los no expuestos.


Muestra de 610 pacientes (edad media=81,1años), 71% mujeres. El 37,2% estaban tomando algún FA. La diferencia media (desviación estándar [DE]) de los expuestos respeto a los no expuestos, el empeoramiento anual en el índice de Barthel, en el índice de Lawton y Brody y en el MMSE fue de4 (4,5),0,3 (0,4) y1 (0,9), respetivamente.


Un tercio de los pacientes que consultan por pérdida cognitiva están tomando algún FA. Los pacientes expuestos muestran una tendencia mayor a empeorar funcionalmente.

Palabras clave:
Antagonistas colinérgicos


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