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Inicio Medicina Clínica (English Edition) An epidemiology survey of vitamin D deficiency and its influencing factors
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Vol. 154. Issue 1.
Pages 7-12 (January 2020)
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Vol. 154. Issue 1.
Pages 7-12 (January 2020)
Original article
An epidemiology survey of vitamin D deficiency and its influencing factors
Un estudio epidemiológico acerca de la deficiencia de vitamina D y sus factores de influencia
Wei Jianga,1, Dong-Bo Wua,1, Gui-Bao Xiaob, Bei Dingc, En-Qiang Chena,
Corresponding author

Corresponding author at: No. 37 Guo Xue Xiang, Wuhou District, Chengdu 610041, Sichuan Province, China.
a Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China
b Department of Infectious Diseases, The First People's Hospital of Ziyang, Ziyang 641300, China
c ADICON Clinical Laboratory, Chengdu 610000, China
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Figures (2)
Tables (2)
Table 1. Demographic and clinical characteristics of the participants.
Table 2. Multivariate logistic regression analyses examining the associations of vitamin D severe shortage deficiency and insufficiency.
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There is growing evidence that vitamin D is related to the development of a variety of diseases. The current study was performed to investigate the status of serum vitamin D distribution among adult Chinese people and reveal the influence of gender, age, seasonality and residential regions on serum vitamin D levels.


This cross-sectional study included 14,302 participants aged from 18 years old to 65 years old from six major cities in China. The basic demographic information and the levels of serum vitamin D (25(OH)D) and vitamin D3 (25(OH)D3) were collected from Jan 2, 2014 to Dec 25, 2017.


The prevalence of 25(OH)D3 concentration <30ng/mL reached up to 83%, in which the rate of vitamin D insufficiency (20–29ng/mL) was 32.7%, and vitamin D deficiency (10–19ng/mL) accounted for 41.9%, and vitamin D severe shortage (<10ng/mL) accounted for 8.4%. Women were more likely to have vitamin D3 deficiency and lower serum vitamin D3 concentration than men (both p<0.001). The mean concentration of serum 25(OH)D and 25(OH)D3 in summer and autumn were higher than that in spring and winter (p<0.001), and the mean concentration of serum 25(OH)D in people from Southern China was higher than that in people from other regions (p<0.001). Although the mean concentrations of serum 25(OH)D and 25(OH)D3 were both increased by age, the percentage of patients with serum 25(OH)D3 insufficiency was also increased.


Serum vitamin D deficiency is very common in adults in China. The level of serum vitamin D may be associated with age, sex, seasonality and residential regions.

Vitamin D
Influencing factor
Adult population

Una gran cantidad de investigaciones muestran que la vitamina D está relacionada con el desarrollo de una variedad de enfermedades. El presente estudio apunta a investigar el estado de la distribución de la vitamina D sérica entre los adultos chinos, y revelar la influencia del género, la edad, la estacionalidad y las regiones residenciales sobre los niveles séricos de vitamina D.


El presente estudio transversal incluyó a 14.302 participantes con edades comprendidas entre de 18 y 65 años, provenientes de las 6 principales ciudades de China. Se recogió la información demográfica básica y se analizó la concentración sérica de vitamina D 25(OH)D y vitamina D3 25(OH)D3 del 2 de enero de 2014 al 25 de diciembre de 2017.


La prevalencia de concentración de 25(OH)D3Y3 y menor concentración sérica de vitamina D3 que los varones (pY3 en verano y otoño era mayor que en primavera e invierno (pY3 aumentaron levemente con la edad, el porcentaje de pacientes con insuficiencia sérica de vitamina D 25(OH)D3 también experimentó un incremento.


La deficiencia sérica de vitamina D es muy común en adultos en China. Es probable que el nivel sérico de vitamina D esté asociado a la edad, el sexo, la estacionalidad y las regiones residenciales.

Palabras clave:
Vitamina D
Factor de influencia
Población adulta


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