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Inicio Medicina Clínica (English Edition) Allogeneic stem cell transplantation in the era of novel therapies for acute lym...
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Vol. 153. Issue 1.
Pages 28-34 (July 2019)
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Vol. 153. Issue 1.
Pages 28-34 (July 2019)
Review
DOI: 10.1016/j.medcle.2019.01.024
Allogeneic stem cell transplantation in the era of novel therapies for acute lymphoblastic leukaemia
El trasplante alogénico de progenitores hematopoyéticos en la era de las nuevas terapias en la leucemia linfoblástica aguda
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Pere Barbaa,
Corresponding author
pbarba@vhio.net

Corresponding author.
, Izaskun Elorzab
a Servicio de Hematología, Hospital Universitario Vall d’Hebron-Universitat Autónoma de Barcelona, Barcelona, Spain
b Unidad de Trasplante de Progenitores Hematopoyéticos Pediátrica, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
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Tables (2)
Table 1. Indications of allogeneic transplantation in adult acute lymphoblastic leukaemia depending on the clinical situation according to the European Society for Bone and Marrow Transplantation (EBMT).
Table 2. Indications for allogeneic transplantation in acute lymphoblastic leukaemia in high-risk adult (PETHEMA AR-2011 Protocol) and paediatric patients (LAL/SHOP-Pethema 2013 Protocol).
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Abstract

Immunotherapy is changing the treatment of acute lymphoblastic leukaemia (ALL) in adults and children. However, regardless of these new therapies, allogeneic hematopoietic cell transplantation (allo-HCT) still play a key role in the treatment of ALL, although it is uncertain how these new therapies will impact on the transplant procedure and indications. This article reviews the indications of allo-HCT for children and adults diagnosed with ALL, the different sources and conditioning regimens for transplantation as well as the role of measurable residual diseases pre- and post-HCT in the era of the new therapies for ALL.

Keywords:
Allogeneic transplantation
Acute lymphoblastic leukaemia
Immunotherapy
Monoclonal antibodies
CAR-T
Resumen

La inmunoterapia está cambiando profundamente el tratamiento de la leucemia linfoblástica aguda (LLA) infantil y del adulto. Sin embargo, a pesar de todos los avances, el trasplante alogénico de progenitores hematopoyéticos (alo-TPH) sigue siendo un pilar fundamental en su tratamiento. Cómo van a modificar estas nuevas terapias la indicación y el procedimiento de trasplante, resulta todavía incierto. En el presente artículo se discuten las indicaciones de TPH en la LLA infantil y del adulto, las posibles fuentes de donantes y acondicionamiento, así como el papel de la enfermedad residual medible en el contexto de la nueva era de tratamientos en el campo de la LLA.

Palabras clave:
Trasplante alogénico
Leucemia linfoblástica aguda
Inmunoterapia
Anticuerpos monoclonales
CAR-T

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