Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Adult onset Still's disease
Journal Information
Vol. 150. Issue 9.
Pages 348-353 (May 2018)
Share
Share
Download PDF
More article options
ePub
Visits
3
Vol. 150. Issue 9.
Pages 348-353 (May 2018)
Review
DOI: 10.1016/j.medcle.2017.10.034
Adult onset Still's disease
Enfermedad de Still del adulto
Visits
...
Javier Narváez
Servicio de Reumatología, Hospital Universitario de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (2)
Table 1. Symptoms and warning signs of macrophage activation syndrome.
Table 2. Diagnostic criteria of the macrophage activation syndrome (or reactive hemophagocytic syndrome) in the systemic forms of juvenile idiopathic arthritis proposed in 2016 by the European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organization Collaborative Initiative.
Show moreShow less
Abstract

Adult onset Still's disease is a rare systemic condition at the crossroads between auto-inflammatory syndromes and autoimmune diseases, with considerable heterogeneity in terms of clinical presentation, evolution and severity. This article reviews the main advances and lesser known aspects of this entity related to its clinical spectrum (atypical cutaneous lesions, unusual manifestations, macrophage activation syndrome, disease phenotypes), the emerging controversy around its association with delayed malignancy, the search for new biomarkers for its diagnosis, evaluation of prognosis (clinical factors, prognostic indexes and biomarkers to identify patients at risk of severe organ failure or life-threatening complications), and the determinants in the choice of biological treatment.

Keywords:
Adult onset Still's disease
Update
Prognostic
Treatment
Resumen

La enfermedad de Still del adulto es una entidad infrecuente a medio camino entre los síndromes autoinflamatorios y las enfermedades autoinmunes, con una gran heterogeneidad en su presentación clínica, gravedad y evolución. En este artículo se revisan las novedades y aspectos menos conocidos de esta enfermedad referidos a su espectro clínico (lesiones cutáneas atípicas, complicaciones distintas de las manifestaciones clásicas, síndrome de activación macrofágica, fenotipos de la enfermedad), a la controversia existente acerca de su posible asociación con neoplasias, la búsqueda de biomarcadores para su diagnóstico, la evaluación del pronóstico (factores clínicos, índices pronósticos y biomarcadores) y los factores determinantes en la elección del tratamiento biológico.

Palabras clave:
Enfermedad de Still del adulto
Actualización
Pronóstico
Tratamiento

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.