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Vol. 152. Issue 10.
Pages 391-394 (May 2019)
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Vol. 152. Issue 10.
Pages 391-394 (May 2019)
Brief report
DOI: 10.1016/j.medcle.2019.03.007
Acute hepatitis due to hepatitis A virus during the 2017 epidemic expansion in Asturias. Spain
Hepatitis aguda por virus de la hepatitis A durante la expansión epidémica de 2017 en Asturias
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Miguel Frailea, Eva Barreiro Alonsob, Juan de la Vegac, Mercedes Rodríguezd, Rosa García-Lópezb, Manuel Rodrígueza,
Corresponding author
manurodrigg@gmail.com

Correspomnding author.
a Unidad de Hepatología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Servicio de Aparato Digestivo, Hospital Universitario de Cabueñes, Gijón, Asturias, Spain
c Servicio de Aparato Digestivo, Hospital Universitario de San Agustín, Avilés, Asturias, Spain
d Laboratorio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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Tables (2)
Table 1. Global characteristics of both groups of patients with AHA.
Table 2. Comparison between patients with severe and non-severe AHA.
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Abstract
Introduction

Since June 2016, there has been an increase in cases of acute hepatitis A (AHA) in several European countries, mainly affecting men who have sex with men (MSM). The aim was to know the characteristics of AHA diagnosed in recent months, comparing them with a previous series.

Patients and methods

All cases of AHA diagnosed in adults between November 2016 and December 2017 (G-I; n=108) were prospectively collected and compared with a series also prospectively collected between January 2004 and September 2016 (G-II; n=49), analysing clinical and epidemiological characteristics.

Results

Compared with group II, in group I there was a greater proportion of males (95.4 vs. 81.6%; p=0.005), of MSM (63.9 vs. 22.4%; p<0.001), of cases with positive luetic serology (20.4 vs 2%; p=0.001) and of severe acute hepatitis (15 vs. 4%; p=0.043).

Conclusions

AHA diagnosed in recent months in our environment mainly affect MSM and have a more serious presentation with respect to what was observed in a historical series, highlighting the need to increase the vaccination rate against the hepatitis A virus.

Keywords:
Hepatitis A virus
Men who have sex with men
Outbreaks
Acute hepatitis A
Resumen
Introducción

Desde junio de 2016 se ha producido un incremento de casos de hepatitis aguda A (HAA) en diversos países europeos, afectando principalmente a hombres que tienen sexo con hombres (HSH). El objetivo fue conocer las características de las HAA diagnosticadas en los últimos meses, comparándolas con una serie precedente.

Pacientes y métodos

Se recogieron prospectivamente todos los casos de HAA diagnosticados en adultos entre noviembre de 2016 y diciembre de 2017 (G-I; n=108) y se compararon con una serie recogida también de forma prospectiva entre enero de 2004 y septiembre de 2016 (G-II; n=49), analizando las características clínico-epidemiológicas.

Resultados

Con respecto al grupo II, en el I se observó una mayor proporción de varones (95,4 vs. 81,6%; p=0,005), de HSH (63,9 vs. 22,4%; p<0,001), de casos con serología positiva de lúes (20,4 vs. 2%; p=0,001) y de hepatitis aguda grave (15 vs. 4%; p=0,043).

Conclusiones

Las HAA diagnosticadas en los últimos meses en nuestro medio afectan fundamentalmente a HSH y tienen con mayor frecuencia un carácter grave respecto a lo observado en una serie histórica, poniendo de manifiesto la necesidad de incrementar la tasa de vacunación frente al virus de la hepatitis A.

Palabras clave:
Virus de la hepatitis A
Hombres que mantienen sexo con hombres
Brote epidémico
Hepatitis aguda A

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