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Inicio Medicina Clínica (English Edition) Non-obstructive jaundice as paraneoplastic syndrome of prostate carcinoma: Syste...
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Vol. 160. Issue 5.
Pages 206-212 (March 2023)
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Vol. 160. Issue 5.
Pages 206-212 (March 2023)
Review
Non-obstructive jaundice as paraneoplastic syndrome of prostate carcinoma: Systematic review of published cases
Ictericia no obstructiva como síndrome paraneoplásico del carcinoma de próstata: revisión de casos publicados
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Ignacio Santandreu-Moralesa, Eduardo Redondo-Cerezob,c, David Martín Enguixd,
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davidm123m45@hotmail.com

Corresponding author.
a Facultad de Medicina, Universidad de Granada, Granada, Spain
b Departamento de Medicina, Universidad de Granada, Granada, Spain
c Servicio de Aparato Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain
d Distrito Sanitario Granada Metropolitano, Centro de La Zubia, La Zubia, Granada, Spain
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Abstract

Stauffer Syndrome is a paraneoplastic syndrome (PS) that involves liver disorders; it has been often relate to renal tumors, but also to others such as adenocarcinoma of the prostate (ACP). Our objective was to carry out a systematic review of published cases associated with ACP. A total of 357 articles were accessed, 25 of which met the study’s inclusion criteria. All published cases of SS in patients diagnoses with ACP were in the metastatic stage. The PS resolved in 3 out of 4 patients when ACP-targeted therapy was implemented. The following were identified as poor prognosis factors: the diagnosis of ACP prior to that of SP, non-elevated levels of total bilirubin, and the non-resolution of SP at the start of treatment.

Keywords:
Prostate adenocarcinoma
Stauffer syndrome
Paraneoplastic syndrome
Resumen

El Síndrome de Stauffer (SS) es un síndrome paraneoplásico (SPN) en el que se produce una afectación hepática; clásicamente se ha relacionado con tumores renales, pero también con otros tumores como el adenocarcinoma de próstata (ACP). Nuestro objetivo es llevar a cabo una revisión sistemática de los casos publicados asociados al cáncer de próstata. El número de artículos cribados en la revisión bibliográfica fue de 357 de los cuales 25 cumplieron los criterios de inclusión. Todos los casos publicados de SS en pacientes con ACP estaban en estadio metastásico. El SPN se resolvió en 3 de cada 4 pacientes cuando se instauró el tratamiento dirigido al cáncer de próstata. La aparición del SPN en pacientes ya diagnosticados de ACP, niveles no elevados de bilirrubina total y la no resolución del SPN se presentaron como factores de mal pronóstico.

Palabras clave:
Adenocarcinoma de próstata
Síndrome de Stauffer
Síndrome paraneoplásico

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