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Medicina Clínica (English Edition) Influence of therapeutic exercise on the symptomatology associated with hematopo...
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Original article
Available online 7 November 2025
Influence of therapeutic exercise on the symptomatology associated with hematopoietic stem cell transplantation
Influencia del ejercicio terapéutico en la sintomatología asociada al trasplante de progenitores hematopoyéticos
Antonio Chamorro Comesañaa,
Corresponding author
, Noa Piñeiro Fernándeza, Patricia Rodríguez Fernándeza, Natalia Fente Garcíab, Francisco Xosé Román Losadab, M. del Carmen Quintela Gonzálezb, Agustín Nieto Vázquezc, Ana Santamaría Lópezc, Judith Vázquez Álvarezc, María del Carmen Albo Lópezc, Angela Prietod
a Unidad de Fisioterapia, Logopedia y Estimulación, Hospital Álvaro Cunqueiro, Vigo, Spain
b Enfermería del Servicio de Hematología, Hospital Álvaro Cunqueíro, Vigo, Spain
c Servicio de Hematología, Hospital Álvaro Cunqueiro, Vigo, Spain
d Statistics and Methodology Unit, Galicia Sur Health Research Institute (ISS Galicia Sur), SERGAS-UVIGO, Vigo, Spain
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Tables (3)
Table 1. Clinical and demographic characteristics.
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Table 2. Results of the first 5 items of the Edmonton Symptom Assessment System questionnaire.
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Table 3. Results for the Remaining Five Items of the Edmonton Symptom Assessment System questionnaire.
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Abstract

Hematopoietic stem cell transplantation (HSCT) is a therapy used for the treatment of numerous pathologies, mainly oncohematological ones it is associated with the appearance of toxicities that can delay the patient's recovery.

Objective

To observe the effect of a therapeutic exercise (TE) program produces on the symptoms reported by patients undergoing HSCT 3 months after the transplant.

Patients and methods

Observational study in patients who underwent HSCT at the Álvaro Cunqueiro Hospital in Vigo between September 2020 and August 2021, with pre-admission assessment and 3 months post-transplant, using Edmonton Symptom Assessment System (ESAS) test. During their hospitalization, the patients followed the ET program based on the HSCT exercise guidelines from the Spanish Group for Transplantation and Cellular Therapy (GETH-TC).

Results

A total of 34 patients participated, and improvements were observed in fatigue, drowsiness, shortness of breath, mood, nervousness and feeling of well-being.

Conclusions

A therapeutic exercise program is safe, and may help reduce common symptoms in transplant patients. Exercise must be adapted to the specific situation of the patient throughout the transplant process.

Keywords:
Therapeutic exercise
Hematopoietic stem cell transplantation
Physical activity
Exercise
Symptomatology
Resumen

El trasplante de progenitores hematopoyéticos (TPH) terapia que se emplea para el tratamiento de numerosas patologías, principalmente oncohematológicas, está asociado a la aparición de toxicidades que pueden retrasar la recuperación del paciente.

Objetivo

Observar el efecto que un programa de ejercicio terapéutico (ET) produce en la sintomatología que refieren los pacientes sometidos a un TPH a los 3 meses del trasplante.

Pacientes y métodos

Estudio observacional en pacientes sometidos a un TPH en el Hospital Álvaro Cunqueiro de Vigo entre septiembre de 2020 y agosto de 2021, con una valoración preingreso y a los 3 meses del trasplante, utilizando el test de Edmonton (Edmonton Symptom Assessment System). Durante el ingreso el paciente ha realizado el programa de ET basado en la guía de ET en TPH del Grupo Español de Trasplante y Terapia Celular.

Resultados

Participaron 34 pacientes en los que se observaron mejoras en fatiga, somnolencia, dificultad para respirar, estado de ánimo, nerviosismo y sensación de bienestar.

Conclusiones

Un programa de ET es seguro, y puede ayudar en la disminución de alguna sintomatología frecuente en el paciente trasplantado.

El ejercicio debe ser adaptado a la situación particular en la que se encuentre a lo largo del proceso de trasplante.

Palabras clave:
Ejercicio terapéutico
Trasplante de progenitores hematopoyéticos
Actividad física
Ejercicio
Sintomatología

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