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Journal Information
Vol. 41. Issue 2.
Pages 118-131 (April - June 2024)
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Vol. 41. Issue 2.
Pages 118-131 (April - June 2024)
Review
Hypertensive states of pregnancy
Estados hipertensivos del embarazo
Visits
7
E. Rubio Gonzaleza,
Corresponding author
estherrg@telefonica.net

Corresponding author.
, A.M. Huerta Arroyoa, F. Garcia Benasachb, T. Gijon Condec
a Nephrology Service, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain
b Gynecology and Obstetrics Service, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Madrid, Spain
c Community of Madrid Ministry of Health, Madrid, Spain
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Tables (7)
Table 1. Classification of hypertensive disorders in pregnancy.
Table 2. Risk factors for the development of pre-eclampsia.
Table 3. Differential diagnosis between PE, HELLP, and aHUS.
Table 4. Drugs for the oral treatment of HTN in pregnancy.
Table 5. Drugs for intravenous treatment of severe HTN in pregnancy.
Table 6. Antihypertensive drugs not indicated in pregnancy.
Table 7. Criteria for the diagnosis of severe PE.
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Abstract

Hypertensive disorders in pregnancy (HDP) remain a leading cause of pregnancy-related maternal and foetal morbidity and mortality worldwide, including chronic hypertension, gestational hypertension, and pre-eclampsia.

Affected women and newborns also have an increased risk of cardiovascular disease later in life, independent of traditional cardiovascular disease risks. Despite these risks, recommendations for optimal diagnosis and treatment have changed little in recent decades, probably due to fear of the foetal repercussions of decreased blood pressure and possible drug toxicity.

In this document we review the diagnostic criteria and classification of (HDP), as well as important aspects regarding pathophysiology and early detection that allows early identification of women at risk, with the aim of preventing both immediate and long-term consequences. Prophylactic treatment with aspirin is also reviewed early and a therapeutic approach is carried out that involves close maternal and foetal monitoring, and if necessary, the use of safe drugs in each situation.

This review aims to provide an updated vision for the prevention, diagnosis, and treatment of HDP that is useful in our usual clinical practice.

Keywords:
Hypertension
Pregnancy
Pre-eclampsia
HELLP
Resumen

Los estados hipertensivos del embarazo (EHE) siguen siendo una de las principales causas de morbilidad y mortalidad materna y fetal relacionada con el embarazo en todo el mundo, incluyen la hipertensión crónica, la hipertensión gestacional y la preeclampsia.

Las mujeres afectadas y los recién nacidos también tienen un mayor riesgo de sufrir enfermedades cardiovasculares en el futuro, independientemente de los riesgos tradicionales de la enfermedad cardiovascular. A pesar de estos riesgos, las recomendaciones para un diagnóstico y un tratamiento óptimo han cambiado poco en las últimas décadas, probablemente por el miedo a las repercusiones fetales de la disminución de la presión arterial y la posible toxicidad farmacológica.

En ese documento revisamos los criterios diagnósticos y la clasificación de los EHE, así como aspectos importantes en cuanto a fisiopatología y la detección temprana que permita la identificación precoz de las mujeres en riesgo, con el objetivo de prevenir tanto las secuelas inmediatas como a largo plazo. También se revisa el tratamiento profiláctico con aspirina de forma precoz y se realiza una aproximación terapéutica que implica una estrecha vigilancia materna y fetal, y si es necesario, el uso de fármacos seguros en cada situación.

Esta revisión pretende dar una visión actualizada para la prevención, diagnóstico y tratamiento de los EHE que sea de utilidad en nuestra práctica clínica habitual.

Palabras clave:
Hipertensión
Embarazo
Preeclampsia
HELLP

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