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Vol. 46. Issue 6.
Pages 474-482 (June - July 2023)
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Vol. 46. Issue 6.
Pages 474-482 (June - July 2023)
Review
Post-COVID cholangiopathy: A narrative review
Colangiopatía post-COVID: revisión narrativa
Visits
98
José Caballero-Alvaradoa, Carlos Zavaleta Corverab,
Corresponding author
carzavcor_1992@hotmail.com

Corresponding author.
, Bryan Merino Bacilioa, Clara Ruiz Caballeroa, Katherine Lozano-Peraltaa
a School of Medicine, Universidad Privada Antenor Orrego, Trujillo, Peru
b Primary Healthcare Center, Essalud, Trujillo, Peru
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Table 1. Characteristics of the included studies.
Table 2. Alterations in hepatic biochemical markers in patients with post-COVID-19 cholangiopathy.
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Abstract

Since the spread of the first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection much progress has been made in understanding the disease process. However, we are still facing the complications of coronavirus disease 19 (COVID-19). Multiple sequelae may appear as a consequence of acute infection. This set of entities called post-COVID-19 syndrome involves a wide variety of new, recurrent or persistent symptoms grouped together as a consequence of the acute disease process. One of those that has attracted the most attention is the liver and bile duct involvement called post-COVID-19 cholangiopathy. This is characterized by elevation of liver markers such as alkaline phosphatase, bilirubin and transaminases as well as alterations in the bile ducts in imaging studies. Thus, a narrative review of the cases reported until the end of 2021 was carried out. From the findings found, we concluded that patients who have had COVID-19 or during the process have required hospitalization should remain under follow-up for at least 6 months by a multidisciplinary team.

Keywords:
Post-COVID-19 cholangiopathy
Post-COVID-19 sclerosing cholangitis
Cholangiopathy
COVID-19
Hepatic injury
Resumen

Desde la propagación de los primeros casos del síndrome respiratorio agudo severo por coronavirus 2 (SARS-CoV-2) se ha avanzado mucho en la comprensión del proceso de enfermedad. Sin embargo, todavía nos enfrentamos a las complicaciones del coronavirus 19 (COVID-19). Se han reportado múltiples secuelas como consecuencia de la infección aguda. Este conjunto, denominado síndrome post-COVID-19, involucra una amplia variedad de síntomas nuevos, recurrentes o persistentes agrupados como consecuencia del proceso agudo de la enfermedad. Una de las que más ha llamado la atención es la afectación hepática y de vías biliares denominada colangiopatía post-COVID-19. Esta se caracteriza por elevación de marcadores hepáticos tales como fosfatasa alcalina, bilirrubina y transaminasas, así como alteraciones en las vías biliares en los estudios de imagen. Así, se realizó una revisión narrativa de los casos reportados hasta finales de 2021. De los hallazgos encontrados concluimos que los pacientes que han tenido COVID-19 o que han requerido hospitalización deben permanecer en seguimiento durante al menos 6 meses por parte de un equipo multidisciplinario.

Palabras clave:
Colangiopatía post-COVID-19
Colangitis esclerosante post-COVID-19
Colangiopatía
COVID-19
Lesión hepática

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