Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Epidemiological and clinical characteristics, and response to treatment in 113 p...
Journal Information
Vol. 44. Issue 10.
Pages 671-679 (December 2021)
Share
Share
Download PDF
More article options
ePub
Visits
4
Vol. 44. Issue 10.
Pages 671-679 (December 2021)
Original article
Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis
Características epidemiológicas, clínicas y respuesta al tratamiento en 113 pacientes con colitis microscópica
Visits
...
Eukene Rojo
Corresponding author
eukenerojo@hotmail.es

Corresponding author.
, María José Casanova, Javier P. Gisbert
Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Madrid, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (4)
Table 1. Comparison between the epidemiological characteristics of collagenous colitis and lymphocytic colitis.
Table 2. Comparison between the main findings in the colonic mucosa of patients with collagenous colitis and lymphocytic colitis.
Table 3. Comparison between the laboratory characteristics of patients with microscopic colitis, collagenous colitis and lymphocytic colitis.
Table 4. Comparison between the efficacy and adverse effects of the different treatments received at the onset of microscopic colitis.
Show moreShow less
Abstract
Objective

To study the epidemiological and clinical characteristics, and response to treatmentin patients with microscopic colitis.

Patients and method

Epidemiological, clinical, blood test and endoscopic data were retrospectively collected from 113 patients with microscopic colitis. Response to treatment was analyzed in 104 of them. Efficacy and relapse after treatment with budesonide were assessed using survival curves (Kaplan-Meier).

Results

78% of the patients were women, with a mean age of 65 ± 16 years. In smokers, the mean age was 10 years younger. 48% of them had some concomitant autoimmune disease; 60% suffered a single outbreak of the disease. The clinical presentation was similar in both subtypes, although patients with collagenous colitis had a chronic course more frequently (48% vs. 29%, P = .047). The remission rate with budesonide was 93% (95% CI 82–98). The cumulative incidence of relapse, after a median follow-up of 21 months, was 39% (95% CI 26%–54%): 19% at one year, 32% at two years, and 46% at three years of follow-up. There were no differences in clinical response to budesonide based on smoking habit or microscopic colitis subtype.

Conclusions

Microscopic colitis is more frequent in elderly women. Smoking was associated with earlier onset of the disease, although it did not influence the clinical course or response to treatment. The majority (>90%) of patients treated with budesonide achieved remission, although nearly half subsequently relapsed.

Keywords:
Microscopic colitis
Collagenous colitis
Lymphocytic colitis
Epidemiology
Budesonide
Resumen
Objetivo

Estudiar las características epidemiológicas, clínicas y la respuesta al tratamiento en pacientes con colitis microscópica.

Pacientes y método

Se recopilaron retrospectivamente los datos epidemiológicos, clínicos, analíticos y endoscópicos de 113 pacientes con colitis microscópica. La respuesta al tratamiento se analizó en 104 de ellos. La eficacia y la recidiva tras la administración de budesonida se evaluaron mediante curvas de supervivencia (Kaplan-Meier).

Resultados

El 78% de los pacientes fueron mujeres, con una edad media de 65 ± 16 años. En los fumadores, la edad media fue 10 años menor. Un 48% tenía alguna enfermedad inmunomediada concomitante. El 60% sufrió un único brote de la enfermedad. La presentación clínica fue similar en ambos subtipos, aunque los pacientes con colitis colágena tuvieron un curso crónico con más frecuencia (48 vs. 29%, P = ,047). La tasa de remisión con budesonida fue del 93% (IC95% = 82–98). La incidencia acumulada de recidiva, tras una mediana de seguimiento de 21 meses, fue del 39% (IC95% = 26%–54%): 19% al año, 32% a los 2 años y 46% a los 3 años de seguimiento. No hubo diferencias en la respuesta clínica a la budesonida en función del tabaquismo o el subtipo de colitis microscópica.

Conclusiones

La colitis microscópica es más frecuente en mujeres de edad avanzada. El tabaco se asoció a una aparición más precoz de la enfermedad, aunque no influyó en la evolución clínica o en la respuesta al tratamiento. La mayoría (>90%) de los pacientes tratados con budesonida alcanzaron la remisión, aunque casi la mitad recidivaron posteriormente.

Palabras clave:
Colitis microscópica
Colitis colágena
Colitis linfocítica
Epidemiología
Budesonida

Article

These are the options to access the full texts of the publication Gastroenterología y Hepatología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Gastroenterología y Hepatología (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos