Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Characterization and prevalence of extraintestinal manifestations in a cohort of...
Journal Information
Vol. 44. Issue 6.
Pages 398-404 (June - July 2021)
Download PDF
More article options
Vol. 44. Issue 6.
Pages 398-404 (June - July 2021)
DOI: 10.1016/j.gastre.2020.07.015
Characterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia
Caracterización y prevalencia de manifestaciones extraintestinales en una cohorte de pacientes con enfermedad inflamatoria intestinal en Medellín (Colombia)
Fabián Juliao-Bañosa,
Corresponding author

Corresponding author.
, Mateo Arrublab, Laura Osoriob, Joselyn Camargoc, Juliana Londoñoc, Camilo Cáceresc, Jhon Carvajala, Gabriel Mosquera-Klingera, Jorge Donadoa,b
a Hospital Pablo Tobón Uribe, Medellín, Colombia
b Universidad Pontificia Bolivariana, Medellín, Colombia
c Universidad de Antioquia, Medellín, Colombia
Article information
Full Text
Download PDF
Figures (3)
Show moreShow less
Tables (1)
Table 1. Type of inflammatory bowel disease and frequency of extraintestinal manifestations.

Extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). Our objective is to characterise and determine the prevalence of MEIs in our cohort of patients with IBD.

Patients and methods

A retrospective study was carried out in adult patients with IBD at the Pablo Tobón Uribe Hospital in Medellín. Colombia. Articular MEIs, primary sclerosing cholangitis (PSC), both ophthalmological and dermatological, were considered. Absolute and relative frequencies were used. The Chi square test of independence was used to compare 2 proportions and the odds ratio (OR) was estimated.


Our registry has 759 patients with IBD, 544 present UC (71.6%), 200 CD (26.3%) and 15 unclassifiable IBD (1.9%); 177 patients with IBD (23.3%) presented EIMs, 123 of 544 (22.6%) with UC and 53 of 200 (26.5%) with CD (OR: 0.81, 95% CI: 0.55–1.17, p=0.31). Regarding the type of EIMs, the articular ones were the most frequent (13.5%), more in CD than in UC (20.0 vs. 11.3%, OR 1.94, 95% CI: 1.25–3.00, p=0.0037). Patients with IBD and EIMs used more antibodies against tumour necrosis factor (anti-TNFs), compared to those without EIMs (43.5 vs. 18.5%, OR 3.38, 95% CI: 2.31–4.90, p=0.0001).


The prevalence of EIMs in our cohort is high (23.3%) and the most frequent type is joint. Anti-TNFs are most used when IBD and EIMs coexist. Our study provides valuable information on the association of EIMs and IBD in Latin America.

Crohn's disease
Ulcerative colitis
Extraintestinal manifestations

Las manifestaciones extraintestinales (MEI) son frecuentes en pacientes con enfermedad inflamatoria intestinal (EII). Nuestro objetivo es caracterizar y determinar la prevalencia de MEI en nuestra cohorte de pacientes con EII.

Pacientes y métodos

Se realizó un estudio retrospectivo en pacientes adultos con EII del Hospital Pablo Tobón Uribe en Medellín (Colombia). Se consideraron MEI articulares, colangitis esclerosante primaria (CEP), oftalmológicas y dermatológicas. Se emplearon frecuencias absolutas y relativas. Para comparar 2proporciones se utilizó la prueba χ2 de independencia y se estimó el odds ratio (OR).


Nuestro registro cuenta con 759 pacientes con EII, 544 presentaban CU (71,6%), 200 EC (26,3%) y 15 EII no clasificable (1,9%). Del total, 177 pacientes con EII (23,3%) presentaron MEI, 123 de 544 (22,6%) con CU y 53 de 200 (26,5%) con EC (OR: 0,81; IC 95%: 0,55-1,17; p=0,31). En cuanto al tipo de MEI, las articulares fueron las más frecuentes (13,5%), más en EC que en CU (20,0 vs. 11,3%; OR 1,94; IC 95%: 1,25-3,00; p=0,0037). Los pacientes con EII y MEI utilizaron más anticuerpos contra el factor de necrosis tumoral (anti-TNF) que aquellos sin MEI (43,5 vs. 18,5%; OR 3,38; IC 95%: 2,31-4,90; p=0,0001).


La prevalencia de MEI en nuestra cohorte es alta (23,3%) y el tipo más frecuente es la articular. Los anti-TNF son más utilizados cuando coexisten EII y MEI. Nuestro estudio aporta información valiosa sobre la asociación de MEI y EII en Latinoamérica.

Palabras clave:
Enfermedad de Crohn
Colitis ulcerativa
Manifestaciones extraintestinales


These are the options to access the full texts of the publication Gastroenterología y Hepatología (English Edition)

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Gastroenterología y Hepatología (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos