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Inicio Enfermedades Infecciosas y Microbiología Clínica (English Edition) Use of ribavirin in viruses other than hepatitis C. A review of the evidence
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DOI: 10.1016/j.eimce.2018.05.018
Available online 16 June 2019
Use of ribavirin in viruses other than hepatitis C. A review of the evidence
Uso de ribavirina en virus distintos de la hepatitis C. Una revisión de la evidencia
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German Ramírez-Olivencia
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germano.76@gmail.com

Corresponding author.
, Miriam Estébanez, Francisco Javier Membrillo, Maria del Carmen Ybarra
Unidad de Aislamiento de Alto Nivel, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain
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Received 16 January 2018. Accepted 08 May 2018
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Tables (4)
Table 1. Notifications of isolated cases of disease due to adenovirus treated with ribavirin.
Table 2. Case series of disease due to adenovirus treated with ribavirin.
Table 3. Cases of disease due to MERS-CoV treated with ribavirin.
Table 4. Case series of disease due to MERS-CoV treated with ribavirin (+ IFN).
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Abstract

Ribavirin is a molecule with antiviral activity against different viruses. In clinical practice, it has made its niche almost exclusively for the treatment of the hepatitis C virus. However, there are other diseases in which it could be of benefit and it has the advantage of being suitable for oral, intravenous and inhaled administration. We conducted a review of the indications of the main drug agencies (Spanish, European and American) and other possible indications, mainly haemorrhagic fevers and coronavirus.

Keywords:
Ribavirin
Virazole
1-f8-d-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Resumen

La ribavirina es una molécula con actividad antiviral sobre diferentes virus. Ha encontrado su hueco en la práctica clínica de forma casi exclusiva para el tratamiento del virus de la hepatitis C, pero existen otras enfermedades que podrían beneficiarse de su empleo. Su disponibilidad para administración por vía oral, por vía intravenosa e inhalada es una característica beneficiosa. En este trabajo se realiza una revisión de las indicaciones en las principales agencias del medicamento (española, europea y americana), así como de otras posibles indicaciones, principalmente sobre fiebres hemorrágicas y coronavirus.

Palabras clave:
Ribavirina
Virazole
1-f8-d-Ribofuranosil-1,2,4-triazol-3-carboxamida

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