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Vol. 33. Issue 4.
Pages 169-174 (July - August 2021)
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Vol. 33. Issue 4.
Pages 169-174 (July - August 2021)
Original article
DOI: 10.1016/j.artere.2021.04.003
Lipid profile and serum folate, vitamin B12 and homocysteine levels in patients with retinal vein occlusion
Perfil lipídico y concentraciones séricas de ácido fólico, vitamina B12 y homocisteína en pacientes con obstrucción venosa retiniana
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José Javier Napal Lecumberria,
Corresponding author
josejavier.napal@scsalud.es

Corresponding author.
, Paula González Boresa, Alicia Cuesta Marína, Francisco Alejandro Caballero Avendañoa, Jose Manuel Olmos Martíneza,b, Jose Luis Hernández Hernándeza,b
a Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain
b Universidad de Cantabria, Santander, Spain
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Tables (2)
Table 1. Demographic data and standard lipid parameter levels and artherogenic indexes in patients with RVO and in controls.
Table 2. Serum levels of folic acid, vitamin B12, homocysteine and percentage of their changes in patients with retinal vein occlusion (RVO) and in the control group.
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Abstract
Background

Retinal vein occlusion (RVO) is mainly related with vascular risk factors (VRF).

Objectives

To analyze the lipid profile and serum folate, vitamin B12 and homocysteine levels, in patients with RVO and a population-based control group.

Patients and methods

Case–control study. Patients with RVO were assessed during an 11-year period.

Results

We included 368 patients and 325 controls of similar age and sex. HDL cholesterol and folate levels were lower (52 [43–63]mg/dL vs. 55 [46–66]mg/dL; p=0.016 and 7 [5–10]ng/mL vs. 9 [7–13]ng/mL; p<0.0001, respectively) and non-HDL cholesterol and homocysteine levels higher (148.9±37.3mg/dL vs. 142.9±34.5mg/dL; p=0.03 and 13.4 [11.2–18.2]μmol/L vs. 11.1 [9.0–14.4]μmol/L; p<0.001) in patients with RVO than controls. Although total cholesterol, LDL-C, and triglyceride levels were higher and serum vitamin B12 levels were lower in RVO patients, these differences did not reach statistical significance.

Conclusions

RVO-patients have lower serum HDL-C and folate levels and higher non-HDL-C and serum homocysteine levels than population-based controls of similar age and sex. In patients with RVO, apart from the lipid profile, determination of serum homocysteine, folate and vitamin B12 levels might be useful, as well as the treatment of their alterations.

Keywords:
Retinal vein occlusion
Lipid profile
Folate
Vitamin B12
Homocysteine
Resumen
Antecedentes

La obstrucción venosa retiniana (OVR) se relaciona fundamentalmente con los factores de riesgo vascular (FRV).

Objetivos

Analizar el perfil lipídico y las concentraciones séricas de ácido fólico, vitamina B12 y homocisteína, en pacientes con OVR y un grupo control poblacional.

Pacientes y métodos

Estudio de casos y controles. Los pacientes con OVR fueron estudiados a lo largo de un periodo de 11 años.

Resultados

Se incluyeron 368 casos y 325 controles de similar edad y sexo. En los pacientes con OVR respecto a los controles, las concentraciones de HDL colesterol y de ácido fólico fueron menores (52 [43-63]mg/dL vs. 55 [46-66]; p=0,016 y 7 [5-10]ng/mL vs. 9 [7-13]; p<0,0001, respectivamente) y las de colesterol no HDL y de homocisteína fueron mayores (148,9±37,3mg/dL vs. 142,9±3; p=0,03 y 13,4 [11,2-18,2]μmol/L vs. 11,1 [9,0-14,4]; p<0,0001). Aunque las cifras de colesterol total, cLDL y triglicéridos fueron mayores y las concentraciones de vitamina B12 fueron menores en los pacientes con OVR, estas diferencias no fueron significativas.

Conclusiones

Los pacientes con OVR tienen concentraciones más bajas de colesterol HDL y de ácido fólico y cifras de colesterol no HDL y homocisteína más elevadas que los controles poblacionales de similar edad y sexo. En estos pacientes, además del perfil lipídico, podría ser útil la determinación de la homocisteína, el folato y la vitamina B12, así como el tratamiento de sus alteraciones.

Palabras clave:
Obstrucción venosa retiniana
Perfil lipídico
Ácido fólico
Vitamina B12
Homocisteína

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