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Inicio Clínica e Investigación en Arteriosclerosis (English Edition) Lipid control in patients with coronary artery disease in a healthcare area in C...
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Vol. 29. Issue 1.
Pages 13-19 (January - February 2017)
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Vol. 29. Issue 1.
Pages 13-19 (January - February 2017)
Original article
DOI: 10.1016/j.artere.2016.09.001
Lipid control in patients with coronary artery disease in a healthcare area in Cáceres (Spain): LIPICERES study
Control lipídico en pacientes con enfermedad coronaria del Área de Salud de Cáceres (España): estudio LIPICERES
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José J. Gómez-Barradoa,
Corresponding author
, Carolina Ortiza, Marta Gómez-Turéganoa, Paula Gómez-Turéganoa, Francisco J. Garcipérez-de-Vargasb, Pablo Sánchez-Calderónb
a Complejo Hospitalario Universitario de Cáceres, Hospital San Pedro de Álcantara, Cáceres, Spain
b Hospital Don Benito-Villanueva, Don Benito, Badajoz, Spain
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Tables (3)
Table 1. Distribution of patients by age range and gender.
Table 2. Mean lipid parameter values (mean±SD).
Table 3. Degree of adherence to lipid targets.
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Abstract
Introduction and objectives

Current guidelines recommend a low-density lipoprotein cholesterol (LDLc) target of <70mg/dl for patients with coronary artery disease. Despite the well-established benefits of strict lipid control, the most recent studies show that control rate of lipid targets are alarmingly low.

An analysis was performed on the lipid targets attained according to current guidelines for the prevention of cardiovascular disease in coronary patients in a Caceres healthcare area.

Methods

An observational and cross-sectional study was carried out in a healthcare area in Caceres (Spain). The study included a total of 741 patients admitted for coronary disease between 2009 and 2015 with available lipid profile in the last 3 years. Total cholesterol, high-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), triglycerides (TG) and non-HDLc were analysed.

Results

The majority (74.4%) of patients were male, with a mean age of 68.5±13.1 years; 76.3±11.8 for women and 65.8±12.6 for men (p<0.001).

A total of 52.3% patients achieved the LDLc target of <70mg/dl, with no gender differences. Only 44.8% of the patients <55 years achieved their lipid targets, compared to 59.3% of the patients >75 years.

About 68.2% of men had an HDLc>40mg/dl, and 54.8% of women had an HDLc>50mg/dl. Overall, 79.4% of patients had a TG<150mg/dl, with no gender differences, and 59.8% had a non-HDLc<100mg/dl.

Conclusions

Approximately one half of patients with coronary disease do not achieve their target lipid levels as defined in the European guidelines, and this rate is less than reported in previous studies.

There are no gender differences in achieving lipid goals, and age is a predictor of adherence.

Keywords:
Dyslipidaemia
Low density lipoprotein cholesterol
Cardiovascular risk
LDLc targets
Resumen
Introducción y objetivos

En pacientes con enfermedad coronaria las guías establecen como objetivo un colesterol asociado a lipoproteínas de baja densidad (cLDL) <70mg/dl. A pesar de las evidencias del beneficio de un estricto control lipídico, el grado de consecución de objetivos es alarmantemente bajo en los estudios más recientes.

Hemos analizado el grado de cumplimiento de objetivos lipídicos en pacientes coronarios de nuestra área sanitaria.

Métodos

Estudio observacional y transversal realizado en el Área de Salud de Cáceres (España). Se incluyeron 741 pacientes coronarios ingresados entre 2009-2015 con un perfil lipídico en los últimos 3 años. Se analizaron: colesterol total, cLDL, colesterol asociado a lipoproteínas de alta densidad (cHDL), triglicéridos (TG) y colesterol-no-HDL.

Resultados

El 74,4% eran varones. La edad media fue de 68,5±13,1 años: 76,3±11,8 en las mujeres y 65,8±12,6 en los varones (p<0,001).

El 52,3% tenían un cLDL<70mg/dl, sin diferencias entre sexos; estaban en objetivos el 44,8% de los pacientes <55 años frente al 59,3% de los >75 años.

Tenían un cHDL>40mg/dl el 68,2% de los varones y un cHDL>50mg/dl el 54,8% de las mujeres. Mostraron unos TG<150mg/dl el 79,4%, sin diferencias entre sexos, y un colesterol-no-HDL<100mg/dl el 59,8%.

Conclusiones

La mitad de pacientes coronarios no alcanzan los objetivos de control lipídico, y esta proporción es muy inferior a la comunicada en estudios previos.

No existen diferencias en el cumplimiento de objetivos por sexos, y la edad es un predictor de cumplimiento.

Palabras clave:
Dislipidemia
Colesterol de las lipoproteínas de baja densidad
Riesgo cardiovascular
Objetivos cLDL

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