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Vol. 34. Issue 5.
Pages 271-284 (September - October 2022)
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Vol. 34. Issue 5.
Pages 271-284 (September - October 2022)
Special article
LDL as a therapeutic target
LDL como objetivo terapéutico
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Ángel Díaz Rodrígueza,
Corresponding author
angeldiazrodriguez88@gmail.com

Corresponding author.
, Teresa Mantilla Moratób
a Médico de Familia, Centro Salud de Bembibre, Profesor Universidad de León, Ponferrada, León, Spain
b Médico de Familia, Centro de Salud Universitario Prosperidad, Madrid, Spain
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Abstract

The incidence of atherosclerotic cardiovsacular disease (ASCVC) has increased in the developed countries. Dyslipidemia is a primary major risk factor for ASCVD and LDL lowering is one of the main objectives. Although treatment goals for dyslipidemias should be personalized in every patient, statins are cost-effective in primary and secondary prevention of ASCVD. New treatments with higher power and greater decreases in LDL, PSCK9 inhibitors, have made a new breakthrough in ASCVD treatment. The 2019 Guidelines for de Management of Dyslipidaemias: Lipid Modification to reduce Cardiovascular Risk (European Society of Cardiology/European Atherosclerosis Society) with the level of evidence and the strength of the recommendations can facilitate the best decisions and benefits to our patients in clinical practice.

Keywords:
LDL cholesterol
Treatment targets
Statins
PSCK9 inhibitors
Disease cardiovascular disease
Resumen

La incidencia de las enfermedades arterioscleróticas ha aumentado en los países desarrollados. La dislipemia es un factor de riesgo cardiovascular mayor y el descenso del LDLc es el objetivo terapéutico. Hay que individualizar los objetivos en cada paciente y las estatinas han demostrado ser un tratamiento coste-efectivo tanto en prevención primaria como en secundaria. La aparición de los inhibidores de PSCK9, más potentes y por tanto consiguiendo un mayor descenso de las cifras de LDLc, son un avance en el tratamiento de la enfermedad cardiovascular. La publicación en 2019 de las Guías de Dislipemias (Sociedad Europea de Cardiología /Sociedad Europea de Arteriosclerosis) con el nivel de evidencia y fuerza de recomendación, pueden ayudar en la toma de decisiones y beneficios para nuestros pacientes en la práctica clínica diaria.

Palabras clave:
LDL colesterol
Objetivos tratamiento
Estatinas
Inhibidores PSCK9
Enfermedad cardiovascular

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