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Vol. 33. Issue 2.
Pages 55-61 (March - April 2021)
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Vol. 33. Issue 2.
Pages 55-61 (March - April 2021)
Original
Association of Inflammatory Markers with Multisite Artery Disease in Patients with Peripheral Arterial Disease
Asociación entre los marcadores inflamatorios y la enfermedad arterial de múltiples vasos en pacientes con enfermedad arterial periférica
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Zafer Yalıma,
Corresponding author
zaferyalm@yahoo.com.tr

Corresponding author.
, Mustafa Aldemirb, Sadık Volkan Emrenc
a Afyonkarahisar Healty Sciences University, Afyonkarahisar, Afyon, Turkey
b Health Sciences University Bursa Higher Specialization Training And Research Hospital, Department of Cardiovascular Surgery, Yuksek Ihtisas Egitim ve Arastirma Hastanesi, Bursa, Turkey
c İzmir Katip Çelebi University, Departments of Cardiology, İzmir Katip Celebi Universitesi Tip Fakultesi, İzmir, Turkey
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Figures (1)
Tables (3)
Table 1. Baseline demographic and clinical characteristics of the patients.
Table 2. Inflammatory markers between groups.
Table 3. Univariate and Multivariate Logistic Regression Analysis for the Presence MSAD.
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Abstract
Introduction

Chronic inflammation plays a considerable role in atherosclerosis and may occur simultaneously in different arteries. This condition is referred to as multisite arterial disease (MSAD). We aimed to investigate the association between inflammatory markers and MSAD.

Methods

In this cross-sectional study we included 526 patients with peripheral artery disease (PAD). Patients with PAD were evaluated by conventional or computed tomography angiography for the presence of coronary artery disease (CAD) and those with at least 30% stenosis were included in the study. Patients were divided into two groups: either MSAD+(PAD and CAD), Group 1) or MSAD- (only PAD without CAD, Group 2). Inflammatory markers were compared between the two groups.

Results

Among all patients, 293 had MSAD while 233 had only PAD. The MSAD+group had higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-neutrophil ratio (PLR) (5.08±0.19, 4.67±0.51, and 207.1±6.23, 169.3±10.8, respectively, p<0.001). In multivariate analysis, HT [odds ratio (OR): 2.40 (1.61-3.59)); p<0.002], male gender [OR: 2.03 (1.29-3.17); p=0.002], DM [OR:1.56 (1.03-2.36); P=0.035], NLR [OR: 1,08 (1.02-1.16); p=0.021, and PLR [OR:1.05 (1.03-1.08); p<0.001] were found to be associated with MSAD.

Conclusion

NLR and PLR are correlated with MSAD and may indicate the extent of atherosclerosis.

Keywords:
Atherosclerosis
Peripheral artery disease
Coronary artery disease
Inflammation
Neutrophil-to-lymphocyte ratio
Platelet-to-neutrophil ratio
Abbreviations:
ACS
CAD
CRR
CVD
DM
HT
LEAD
LMR
MHR
MSAD
NLR
PAI
PLR
Resumen
Introducción

La inflamación crónica juega un papel importante en la aterosclerosis, pudiendo producirse de manera simultánea en diferentes arterias. Esta condición se define como enfermedad arterial de múltiples vasos (MSAD). Nuestro objetivo fue estudiar la asociación entre los marcadores inflamatorios y MSAD.

Métodos

En este estudio transversal incluimos 526 pacientes con enfermedad arterial periférica (EAP), quienes fueron evaluados mediante angiografía convencional o angiografía por tomografía computarizada para cribar la presencia de enfermedad de las arterias coronarias (EAC), incluyéndose en el estudio a aquellos pacientes con un 30% mínimo de estenosis. Se dividió a los pacientes en dos grupos: Grupo 1: MSAD+(EAP y EAC); Grupo 2: MSAD-(sólo EAP sin EAC). Se compararon los marcadores inflamatorios entre los dos grupos.

Resultados

De entre todos los pacientes, 293 tenían MSAD, mientras que 233 tenían solo EAP. El Grupo MSAD+tenía mayor índice neutrófilos/linfocitos (INL) e índice plaquetas/neutrófilos (IPN) (5,08±0,19; 4,67±0,51; y 207,1±6,23; 169,3±10,8, respectivamente, p<0,001). En el análisis multivariante se encontró que HT (odds ratio [OR]: 2,40 [1,61-3,59]; p<0,002), sexo masculino (OR: 2,03 [1,29-3,17]; p=0,002), DM (OR:1,56 [1,03-2,36]; p=0,035), INL (OR: 1,08 [1,02-1,16]; p=0,021), e IPL (OR:1,05 [1,03-1,08]; p<0,001) estaban asociados a MSAD.

Conclusión

INL e IPN están correlacionados con MSAD, lo cual puede ser indicativo del alcance de la aterosclerosis.

Palabras clave:
Aterosclerosis
Enfermedad arterial periférica
Enfermedad de las arterias coronarias
Inflamación
Índice neutrófilos/linfocitos
Índice plaquetas/neutrófilos

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