Article information
Abstract
Hereditary nonpolyposis colorectal cancer or Lynch Syndrome, caused by germinal mutations in mismatch deoxyribonucleic acid (DNA) repair genes, is the most common form of hereditary colorectal cancer. The identification of these individuals is not easy and is based on clinical and molecular criteria. A review is presented on the genetics and diagnosis in Lynch Syndrome, as well as on its surgical management and prevention.
Keywords:
Lynch
Colorectal cancer
Genetics Surgery
Resumen
El cáncer colorrectal hereditario no polipósico o síndrome de Lynch, causado por mutaciones germinales en genes reparadores de bases desapareadas de ácido desoxirribonucleico (ADN), es la forma más frecuente de cáncer colorrectal hereditario. La identificación de estos individuos no es fácil y se basa en criterios clínicos y moleculares. Se expone a continuación una revisión sobre genética y diagnóstico en el síndrome de Lynch, así como sobre su manejo quirúrgico y prevención.
Palabras clave:
Lynch
Cáncer colorrectal
Genética
Cirugía
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