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Inicio Cirugía Española (English Edition) Efficacy of hyperthermia pleurodesis: A comparative experimental study on serous...
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Vol. 100. Issue 4.
Pages 209-214 (April 2022)
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Vol. 100. Issue 4.
Pages 209-214 (April 2022)
Original article
Efficacy of hyperthermia pleurodesis: A comparative experimental study on serous membrane of abdominopelvic and thoracic cavities of rats
Eficacia de la pleurodesis por hipertermia: un estudio experimental comparativo sobre la membrana serosa de las cavidades abdominopélvica y torácica de ratas
Francisco Rivasa,
Corresponding author

Corresponding author.
, Rosa-María Peninb, Iván Macíac, Anna Ureñaa, Carlos Déniza, Álvaro Gimenod, Ignacio Escobara, Ricard Ramosc
a Department of Thoracic Surgery, Hospital Universitari de Bellvitge, Medical School, University of Barcelona, L’Hospitalet de Llobregat, Spain
b Department of Pathology, Hospital Universitari de Bellvitge, Medical School, University of Barcelona, L’Hospitalet de Llobregat, Spain
c Department of Thoracic Surgery, Hospital Universitari de Bellvitge and Unit of Human Anatomy and Embryology, Medical School, University of Barcelona, L’Hospitalet de Llobregat, Spain
d Animal Laboratory, Campus Ciències de la Salut de Bellvitge, Universitat de Barcelona, L’Hospitalet de Llobregat, Spain
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Table 1. Microscopic and macroscopic scores.

Pleurodesis is a common technique for treating the accumulation of air or liquid in the pleural space caused by pneumothorax or pleural effusion, it is based on the bounding of pleural layers through induced inflammatory lesions. There are several pleurodesis procedures.


To test and describe the inflammatory effect of hyperthermia on the pleural and peritoneal mesothelia of rats, with the aim of testing the effectiveness of this process for inducing pleurodesis.


35 Sprague-Dawley (male/female) rats were randomized into four treatment groups: Group A (Talc, 10 individuals); group B (control, 5 individuals); group C (hyperthermic isotonic saline, 10 individuals); and group D (filtrate air at 50°, 10 individuals). Inflammatory effect of hyperthermia was the primary outcome parameter.


In the talc group, minimal adhesions between both pleural and peritoneal layers were observed in seven rats. Talc produced peritoneal mesothelium inflammation and fibrosis associated to foreign body giant cells in 80% (8/10) of the sample. Furthermore, clear evidence of a granulomatous foreign-body reaction was detected. No macroscopic and/or microscopic damage was registered in the remaining three groups (control, hyperthermic, and filtrate air).


Talc is an excellent method for producing pleuro-peritoneal inflammatory lesions. On the contrary, hyperthermia apparently does not induce the macroscopic and microscopic damage that is required for efficient pleurodesis. Therefore, hyperthermia should not be used for pleurodesis procedures.

Pleural effusion

La pleurodesis es una técnica común como tratamiento de la patología pleural, ya sea en el neumotórax o el derrame pleural; se basa en la delimitación de las capas pleurales mediante lesiones inflamatorias inducidas. Existen múltiples procedimientos para conseguir una sínfisis pleural.


Estudiar y describir el efecto inflamatorio de la hipertermia sobre el mesotelio pleural y peritoneal de ratas con el objetivo de valorar si presenta un efecto sinfisiante y por tanto útil para conseguir la pleurodesis.


Treinta y cinco ratas Sprague-Dawley (hembras/machos) fueron aleatorizadas en 4 grupos de tratamiento: grupoA (talco, 10 animales); grupoB (control, 5 animales); grupoC (suero salino hipertérmico: 10 animales), y grupoD (aire filtrado a 50°, 10 animales).


En el grupo de talco se evidenciaron adherencias entre las dos membranas pleurales y peritoneales en 7 animales. Se observó inflamación, fibrosis asociada a células gigantes de cuerpos extraño en el 80% (8/10) del mesotelio peritoneal. Paralelamente, se observó reacción granulomatosa a cuerpo extraño. No se registraron lesiones macroscópicas ni microscópicas en el resto de grupos estudiados (control, hipertermia y aire filtrado).


El talco es un excelente método para producir inflamación a nivel del mesotelio pleural y peritoneal. Por el contrario, la hipertermia no parece inducir lesiones macroscópicas ni microscópicas requeridas para conseguir una pleurodesis eficaz.

Palabras clave:
Derrame pleural


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