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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) Macular and choroidal thickness in Down syndrome by swept-source optical coheren...
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Vol. 96. Issue 11.
Pages 618-622 (November 2021)
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Vol. 96. Issue 11.
Pages 618-622 (November 2021)
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Macular and choroidal thickness in Down syndrome by swept-source optical coherence tomography (SS-OCT)
Espesor macular y coroideo en el síndrome de Down mediante swept-source tomografía de coherencia óptica (SS-OCT)
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O. Estebana,b,
Corresponding author
oliviaestebanfloria@hotmail.com

Corresponding author.
, C. Marcuelloc, M. Martinezd, L. Lavillae, S. Marcoa, F.J. Ascasoa,b
a Departamento de Oftalmología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
b Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
c Departamento de Psicología y Sociología, Universidad de Zaragoza, Zaragoza, Spain
d Hospital San Pedro, Logroño, Spain
e Hospital Universitario Miguel Servet, Zaragoza, Spain
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Tables (2)
Table 1. Demographic and clinical data: mean retinal, choroidal and ganglion thickness (μm) and in sections.
Table 2. BCVA and correlation of retinal and choroidal cell layer thicknesses (μm) in sections for the Down syndrome group.
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Abstract

Down syndrome (DS) is associated with certain structural and functional disorders in the whole visual system. The purpose was to compare retinal and choroidal thickness using swept-source optical coherence tomography (SS-OCT) in DS subjects with controls. This cross-sectional study included 100 eyes of 52 DS subjects and 78 eyes of 39 matching age and axial length controls. Our results showed that inner or outer retinal and ganglionar thickness showed no significant differences between DS and control group (p > 0.05). However, retinal foveal thickness (rFT), ganglion foveal thickness (gFT) were significantly higher in DS group than in controls, whereas choroidal foveal thickness (cFT) and some choroidal quadrants of inner and outer rings were significantly lower (p < 0.05). This the first pilot study to provide information about macular and choroidal thicknesses in SD using SS-OCT compared to controls. Further analyses with larger numbers of subjects are needed to confirm our results.

Keywords:
Macular thickness
Choroidal thickness
Swept-source optical coherence tomography
SS-OCT
Down syndrome
Resumen

El síndrome de Down (SD) se asocia a diversos trastornos estructurales y funcionales en la totalidad del sistema visual. El propósito del estudio fue comparar el grosor retiniano y coroideo utilizando tomografía de coherencia óptica swept-source (SS-OCT) en sujetos con SD y controles. Este estudio transversal incluye 100 ojos de 52 sujetos SD y 78 ojos de 39 controles de edad y longitud axial concordantes. Los resultados mostraron que el grosor retiniano interno o externo y el grosor ganglionar no presentaron diferencias significativas entre los sujetos con SD y el grupo de control (p > 0,05). Sin embargo, el grosor retiniano foveal (rFT) y el grosor ganglionar foveal (gFT) fueron significativamente superiores en el grupo SD que en los controles, mientras que el grosor foveal coroideo (cFT) y algunos cuadrantes coroideos de los anillos interno y externo fueron significativamente inferiores (p < 0,05). Este es el primer estudio piloto que proporciona información sobre los grosores macular y coroideo en SD utilizando SS-OCT comparado con controles. Es necesario realizar análisis adicionales con grupos mayores de sujetos para confirmar estos resultados.

Palabras clave:
Grosor macular
Grosor coroideo
Tomografía de coherencia óptica swept-source
SS-OCT
Síndrome de Down

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