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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) Lymphoma and unilateral diffuse uveal melanocytic proliferation: when both condi...
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Vol. 95. Issue 2.
Pages 98-102 (February 2020)
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Vol. 95. Issue 2.
Pages 98-102 (February 2020)
Short communication
DOI: 10.1016/j.oftale.2019.10.003
Lymphoma and unilateral diffuse uveal melanocytic proliferation: when both conditions co-exist in the eye
Linfoma y proliferación melanocítica uveal difusa unilateral: cuando ambas entidades coexisten en el ojo
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R. Campos Poloa,
Corresponding author
rafacampospolo@hotmail.com

Corresponding author.
, D. García Guisadoa, C. Rubio Sáncheza, P. Bueno Garcíab, N.T. Márquez Ivacevichc
a Hospital Virgen del Puerto, Plasencia, Cáceres, Spain
b Hospital Perpetuo Socorro, Badajoz, Spain
c Hospital Campo Arañuelo, Navalmoral de la Mata, Cáceres, Spain
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Abstract

The case is presented of a 60 year-old male with decreased visual acuity in his left eye (LE). In the funduscopic examination, pigmentary alterations associated with sub-retinal orange plaques could be observed that, in autofluorescence, manifested as hypoautofluorescent spots. Subsequently, the patient subsequently developed significant vitritis with large white sub-retinal plaques on the posterior pole of his LE, with no alterations in the right eye. The IL-10/IL-6 coefficient was 0.87, and a lesion suggestive of a lymphoma in the frontal lobe could be seen on brain magnetic resonance scan. The patient was diagnosed with primary lymphoma of the central nervous system with ocular involvement of the LE and associated unilateral diffuse uveal melanocytic proliferation (DUMP) of the same eye.

DUMP is a bilateral para-neoplastic process that occurs as a consequence of carcinomatous tumour processes, although it does not always meet these characteristics.

Keywords:
Diffuse uveal melanocytic proliferation
IL-10/IL-6
Ocular lymphoma
Central nervous system lymphoma
Paraneoplastic ocular syndrome
Resumen

Varón de 60 años que presenta disminución de agudeza visual rápida y progresiva en su ojo izquierdo (OI). En la exploración funduscópica, se pueden observar alteraciones pigmentarias asociadas a placas anaranjadas sub-retinianas que, mediante autofluorescencia, aparecen como múltiples puntos hipoautofluorescentes en polo posterior. A los 3 meses, el paciente desarrolla una importante vitritis asociada a grandes placas blanco-amarillentas sub-retinianas en el polo posterior del OI; el ojo derecho no presenta alteraciones. El coeficiente intravítreo IL-10/IL-6 fue de 0,87 y la resonancia nuclear magnética cerebral evidenció una lesión densa en el lóbulo frontal, sugestiva de linfoma. Se diagnosticó al paciente de un linfoma primario del sistema nervioso central, con afectación ocular de su OI, que se asoció a una proliferación melanocítica uveal difusa (PMUD) del mismo ojo. La PMUD se trata de un proceso paraneoplásico bilateral que ocurre como consecuencia de procesos tumorales carcinomatosos, aunque no siempre cumple estas características.

Palabras clave:
Proliferación melanocítica uveal difusa
IL-10/IL-6
Linfoma ocular
Linfoma del sistema nervioso central
Síndrome paraneoplásico ocular

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